Monitoring the Course of Lupus: New Test for Systemic Lupus Erythematosus

August 27, 1996

REHOVOT, ISRAEL, AUGUST 15, 1996...Doctors may soon find it easier to evaluate the effectiveness of treatment for systemic lupus erythematosus, a potentially life- threatening disease that affects the kidneys and other internal organs, thanks to a new test developed by Prof. Roald Nezlin of the Weizmann Institute,s Immunology Department.

In systemic lupus erythematosus, the immune system's "weapons" certain cells and antibodies damage to body organs is believed to be caused by complexes formed by antibodies and DNA, the genetic material of cells. One of the indications that treatment is effective is a drop in the levels of these complexes in the patient,s blood, yet standard tests can measure only the levels of unattached antibodies.

The new Weizmann Institute test, described in the *Immunology Methods Manual* that will appear in September, solves this problem by measuring the quantity of DNA in the harmful complexes. In this method, microscopic sugar beads absorb the complexes and are deposited on a cellulose membrane. Simple washing procedures are used to break down the complexes and the amount of DNA fragments left behind on the membrane is then measured.

This approach could also be used to measure antibody complexes involved in other autoimmune diseases. A patent application for the new test has been submitted by Yeda Research and Development Co.


CONTACTS:

For press in the U.S., contact: Julie Osler (212) 779-2500
Director of Public Affairs
American Committee for the
Weizmann Institute of Science
(212) 779-2500
JULIE@ACWIS.ORG CompuServe: 76675,366


For foreign press, contact: Luba Vikhanski
Acting Head, Foreign Press and Publications
Weizmann Institute of Science
Rehovot, Israel
011 972 8 934 3855
RRLUBA@weizmann.weizmann.ac.il


American Committee for the Weizmann Institute of Science

Related DNA Articles from Brightsurf:

A new twist on DNA origami
A team* of scientists from ASU and Shanghai Jiao Tong University (SJTU) led by Hao Yan, ASU's Milton Glick Professor in the School of Molecular Sciences, and director of the ASU Biodesign Institute's Center for Molecular Design and Biomimetics, has just announced the creation of a new type of meta-DNA structures that will open up the fields of optoelectronics (including information storage and encryption) as well as synthetic biology.

Solving a DNA mystery
''A watched pot never boils,'' as the saying goes, but that was not the case for UC Santa Barbara researchers watching a ''pot'' of liquids formed from DNA.

Junk DNA might be really, really useful for biocomputing
When you don't understand how things work, it's not unusual to think of them as just plain old junk.

Designing DNA from scratch: Engineering the functions of micrometer-sized DNA droplets
Scientists at Tokyo Institute of Technology (Tokyo Tech) have constructed ''DNA droplets'' comprising designed DNA nanostructures.

Does DNA in the water tell us how many fish are there?
Researchers have developed a new non-invasive method to count individual fish by measuring the concentration of environmental DNA in the water, which could be applied for quantitative monitoring of aquatic ecosystems.

Zigzag DNA
How the cell organizes DNA into tightly packed chromosomes. Nature publication by Delft University of Technology and EMBL Heidelberg.

Scientists now know what DNA's chaperone looks like
Researchers have discovered the structure of the FACT protein -- a mysterious protein central to the functioning of DNA.

DNA is like everything else: it's not what you have, but how you use it
A new paradigm for reading out genetic information in DNA is described by Dr.

A new spin on DNA
For decades, researchers have chased ways to study biological machines.

From face to DNA: New method aims to improve match between DNA sample and face database
Predicting what someone's face looks like based on a DNA sample remains a hard nut to crack for science.

Read More: DNA News and DNA Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.