Optimal timing of invasive evaluation after heart attack examined in randomized trial

August 28, 2018

Munich, Germany - 28 Aug 2018: The optimal timing of invasive evaluation after a heart attack has been examined in a randomised trial. The late breaking results from the VERDICT trial are presented today in a Hot Line Session at ESC Congress 2018.1

Clinical outcome in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) has progressively improved within the last two decades, in part because of faster diagnosis with invasive coronary angiography, followed by the method of revascularisation deemed most appropriate (bypass surgery or inserting a stent). NSTE-ACS includes a type of heart attack labelled non-ST-segment elevation myocardial infarction (NSTEMI) and unstable angina.

ESC guidelines on NSTE-ACS recommend invasive examination and treatment within two hours (immediate invasive strategy) in patients at very high risk of death or myocardial infarction following an initial acute coronary syndrome, within 24 hours in those at high risk (early invasive strategy), and within 72 hours in patients at intermediate risk.2

The VERDICT trial3examined in a randomised set-up whether invasive coronary angiography and treatment (if deemed necessary) within 12 hours (very early invasive strategy) was superior to evaluation and treatment if necessary within 48 to 72 hours in high risk patients with NSTEMI and unstable angina.

The trial enrolled 2,147 patients with NSTEMI or unstable angina (inclusion criteria were either troponin rise and/or ST-segment/T-wave changes). Patients were randomised in a 1:1 ratio to very early coronary angiography and possible treatment within 12 hours or deferred coronary angiography and possible treatment within 48 to 72 hours. Patients were followed-up for at least 18 months for all-cause death, non-fatal myocardial infarction, hospital admission for refractory ischaemia, or hospital admission for heart failure (the primary endpoint).

The average age of patients was 64 years and 66% were men. A total of 1,075 patients were assigned to very early testing which was performed a median of 4.7 hours after randomisation, whereas the 1,072 in the deferred group were examined a median of 61.6 hours after randomisation. Eight in ten patients had elevated biomarkers, 60% had ECG changes indicating new ischaemia, and nearly 50% had a GRACE score4 above 140 at the time of randomisation - all factors which qualify patients as high risk.

During a median follow-up of 4.3 years the primary endpoint occurred in 27.5% of the very early group and 29.5% of the deferred group (p=0.29). In the subgroup of patients with a GRACE score above 140, however, a very early invasive strategy improved outcome compared to a deferred strategy (hazard ratio [HR] 0.81, 95% confidence interval [CI] 0.67-1.00). There was no difference between groups in the rate of complications. There were fewer recurrent myocardial infarctions in the very early, compared to deferred, group (HR 0.73, CI 0.56-0.96, p=0.025).

Professor Thomas Engstrøm, study author, Copenhagen University Hospital, Denmark, said: "Very early diagnosis and treatment was not superior to the deferred strategy. The results suggest that postponing invasive examination and treatment for up to 72 hours is as good as a very early approach in patients with NSTE-ACS. In line with ESC guidelines, for the subgroup of NSTE-ACS patients with a GRACE score above 140, a very early invasive strategy may be indicated."
Notes to editors

SOURCES OF FUNDING: Danish Agency for Science, Technology and Innovation, Danish Council for Strategic Research, The Research Council Rigshospitalet.

DISCLOSURES: Professor Engstrøm reports personal fees from Bayer, Abbott, Boston Scientific, Medtronic and Novo Nordisk.


1"VERDICT - Early versus deferred invasive examination and treatment of patients with Non-ST-segment elevation acute coronary syndrome" will be discussed during:

* Press Conference - Hot Line - Late Breaking Clinical Trials 4 on Tuesday 28 August at 08:00 CEST.

* Hot Line Session 4 on Tuesday 28 August from 11:00 to 12:30 CEST in the Munich Auditorium.

2Roffi M, Patrono C, Collet JP, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J. 2016;37:267-315. doi:10.1093/eurheartj/ehv320

3VERDICT trial: Very EaRly vs Deferred Invasive evaluation using Computerised Tomography.

4The Global Registry of Acute Coronary Events (GRACE) calculator predicts the risk of death or myocardial infarction following an initial acute coronary syndrome.

About the European Society of Cardiology

The European Society of Cardiology brings together health care professionals from more than 150 countries, working to advance cardiovascular medicine and help people lead longer, healthier lives.

About ESC Congress 2018

ESC Congress is the world's largest and most influential cardiovascular event contributing to global awareness of the latest clinical trials and breakthrough discoveries. ESC Congress 2018 takes place 25 to 29 August at the Messe München in Munich, Germany. Explore the scientific programme.

More information is available from the ESC Press Office at press@escardio.org.

European Society of Cardiology

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