Monkeys in zoos have human gut bacteria

August 30, 2016

A new study led by the University of Minnesota shows that monkeys in captivity lose much of their native gut bacteria diversity and their gut bacteria ends up resembling those of humans. The results suggest that switching to a low-fiber, Western diet may have the power to deplete most normal primate gut microbes in favor of a less diverse set of bacteria.

The study was published in the most recent issue of the Proceedings of the National Academy of Sciences (PNAS), a leading scientific journal.

The microbiome (or gut bacteria) has been tied to a wide variety of medical conditions from autism to obesity. The lack of fiber in modern Western diets is often thought to cause harmful perturbations to the human gut microbiome. However, the causes and consequences of how the gut bacteria of humans changes as societies become modernized and westernized is still a mystery because there are too many variables when studying humans.

To better understand how changes in diet, lifestyle, and exposure to modern medicine affect primates' guts, a team of researchers led by University of Minnesota computer science and engineering professor Dan Knights, veterinary medicine professor Tim Johnson, and veterinary medicine Ph.D. student Jonathan Clayton, used DNA sequencing to study the gut microbes of multiple non-human primates species in the wild and in captivity as a model for studying the effects of emigration and lifestyle changes.

The researchers studied two different species: the highly endangered red-shanked douc and the mantled howler monkey. The authors then compared the captive primate microbiomes to the microbiomes of their wild counterparts and to those of modern humans living in developing nations and in the United States.

What they found could be considered alarming. Not only did captive monkeys lose most of their natural wild gut bacteria, but they very consistently all acquired the same new and less diverse set of bacteria--the same bacteria living in our own modern human guts. Across several different zoos on three different continents, all captive primate microbiomes showed the same pattern of converging toward the modern human microbiome.

"We don't know for certain that these new modern human microbes are bad, but on the other hand many studies are now showing that we evolved together with our resident microbes," said Knights. "If that is the case, then it is likely not beneficial to swap them out for a totally different set."

In the wild, each primate species had its own signature fingerprint of microbes. Yet in captivity, they all lost their distinctive microbes and ended up being dominated by the same bacteria that dominate our human guts--species of Bacteroides and Prevotella.

This, along with other analyses to rule out confounding factors like genetics, geography and antibiotic usage, suggested a simple explanation for why the captive primate guts looked more like human guts on the inside--they weren't eating enough plants.

To test whether a partial loss of plant-derived dietary fiber would result in a partial loss of native gut microbes, the authors also collected fecal samples from a semi-captive population of red-shanked doucs who lived in a sanctuary and received about half of the normal variety of plants eaten by wild doucs. Interestingly, these semi-captive animals' microbiomes fell right in between those of the wild and captive doucs, further supporting they hypothesis that lower plant consumption causes loss of microbial diversity.

By comparing DNA sequenced from primate stool samples to plant genomes the authors were able to actually measure the amount and diversity of plants being consumed by the captive and wild primates, and the difference was stark. Wild primate stool contained up to 40 percent plant DNA, while the captive primate stool contained almost none.

"We think this study underscores the link between fiber-rich diets and gut microbiome diversity," Knights said.
This research was funded primarily by a variety of grants from the Morris Animal Foundation, University of Minnesota, Margot Marsh Biodiversity Foundation, Mohamed bin Zayed Species Conservation Fund, and a PharmacoNeuroImmunology Fellowship through the National Institutes of Health.

To read the full research paper, entitled "Captive primate microbiomes converge toward the modern human microbiome," visit the PNAS website.

University of Minnesota

Related Bacteria Articles from Brightsurf:

Siblings can also differ from one another in bacteria
A research team from the University of Tübingen and the German Center for Infection Research (DZIF) is investigating how pathogens influence the immune response of their host with genetic variation.

How bacteria fertilize soya
Soya and clover have their very own fertiliser factories in their roots, where bacteria manufacture ammonium, which is crucial for plant growth.

Bacteria might help other bacteria to tolerate antibiotics better
A new paper by the Dynamical Systems Biology lab at UPF shows that the response by bacteria to antibiotics may depend on other species of bacteria they live with, in such a way that some bacteria may make others more tolerant to antibiotics.

Two-faced bacteria
The gut microbiome, which is a collection of numerous beneficial bacteria species, is key to our overall well-being and good health.

Microcensus in bacteria
Bacillus subtilis can determine proportions of different groups within a mixed population.

Right beneath the skin we all have the same bacteria
In the dermis skin layer, the same bacteria are found across age and gender.

Bacteria must be 'stressed out' to divide
Bacterial cell division is controlled by both enzymatic activity and mechanical forces, which work together to control its timing and location, a new study from EPFL finds.

How bees live with bacteria
More than 90 percent of all bee species are not organized in colonies, but fight their way through life alone.

The bacteria building your baby
Australian researchers have laid to rest a longstanding controversy: is the womb sterile?

Hopping bacteria
Scientists have long known that key models of bacterial movement in real-world conditions are flawed.

Read More: Bacteria News and Bacteria Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to