Nav: Home

Biosensor could help diagnose illnesses directly in serum

August 30, 2017

In this age of fast fashion and fast food, people want things immediately. The same holds true when they get sick and want to know what's wrong. But performing rapid, accurate diagnostics on a serum sample without complex and time-consuming manipulations is a tall order. Now, a team reports in ACS Sensors that they have developed a biosensor that overcomes these issues.

Field-effect transistor (FET)-based biosensors are ideal for point-of-care diagnostics because they are inexpensive, portable, sensitive and selective. They also provide results quickly and can be mass produced to meet market demand. These sensors detect the change in an electric field that results from a target compound, such as a protein or DNA, binding to it. But serum has a high ionic strength, or a high concentration of charged ions, that can mask the targets. Previous research has reported use of pretreatment steps, complex devices, and receptors with different lengths and orientations on the sensor surface, but with limited success. Alexey Tarasov and colleagues wanted to develop a new approach that would make it easier for FETs to be made as point-of-care diagnostic devices for serum analyses.

The researchers developed a FET sensor that included antibody fragments and polyethylene glycol molecules on a gold surface, which they linked to a commercially available transducer. In this configuration, different sensor chips can be swapped out for use with the same transducer. As a proof-of-principle, they tested the sensor with human thyroid-stimulating hormone. The team found that they could detect the hormone at sub-picomolar concentrations, well below the detection limit previously reported with FETs, when testing it at elevated temperatures. They say that the device could be modified to diagnose many conditions and illnesses, and is inexpensive and easy to use.
-end-
The authors acknowledge funding from the Roche Diagnostics GmbH.

The paper's abstract will be available on Aug. 30 at 8 a.m. Eastern time here: http://pubs.acs.org/doi/abs/10.1021/acssensors.7b00187

The American Chemical Society is a not-for-profit organization chartered by the U.S. Congress. ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. ACS does not conduct research, but publishes and publicizes peer-reviewed scientific studies. Its main offices are in Washington, D.C., and Columbus, Ohio.

To automatically receive news releases from the American Chemical Society, contact newsroom@acs.org.

Follow us: Twitter | Facebook

American Chemical Society

Related Fast Food Articles:

Study shows that cafes, restaurants and fast food outlets, and schools, are key sources of unhealthy, non-core foods for adolescents
Adolescents are getting many of their unhealthy, non-core foods such as soft drinks, chips, and sweets from cafes, restaurants, fast-food outlets (collectively called 'eateries'), and schools, according to a UK study presented at this year's European Congress on Obesity in Porto, Portugal.
For richer or poorer, we all eat fast food
Whether rich or poor, one thing unites Americans of all economic classes: Our love for fast food.
Researchers find strong link between fast-food ads and consumption among pre-schoolers
Pre-school age children who are exposed to child-targeted fast-food advertising on television are considerably more likely to consume fast-food products, according to a recent Dartmouth-led study in the journal Public Health Nutrition.
Journal: Researchers can track hazardous chemicals from fast-food wrappers in the body
Just one month after major research findings showed dangerous PFAS present in more than one-third of fast food packaging tested, UAB and Notre Dame created a new technique to track PFASs in the body.
Fast food packaging contains potentially harmful chemicals that can leach into food
A comprehensive analysis of fast food packaging in the US shows that many restaurants use food packaging containing highly fluorinated chemicals, or PFASs.
Some fast-food packaging contains potentially harmful fluorinated compounds
Grease-proof packaging has helped make pizzas, burgers and tacos on-the-go a less messy proposition.
New study finds extensive use of fluorinated chemicals in fast food wrappers
Previous studies have linked the chemicals to kidney and testicular cancers, thyroid disease, low birth weight and immunotoxicity in children, among other health issues.
Children with higher genetic risk for obesity respond more strongly to fast food ads
Dartmouth researchers have found that children with a genetic risk for obesity had greater activity in brain reward centers when watching fast food commercials, which could help us to understand why some children are more likely to overeat.
Food supply -- not 'live fast, die young' mentality -- makes male crickets chirpy
Shedding a few pounds might be a good strategy in the human dating game, but for crickets the opposite is true.
Delayed gratification associated with fast food frequency
A new study led by the American Cancer Society suggests that an ability to delay immediate gratification is associated with less frequent consumption of fast food.

Related Fast Food Reading:

Fast Food Nation: The Dark Side of the All-American Meal
by Eric Schlosser (Author)

New York Times Bestseller

“Schlosser has a flair for dazzling scene-setting and an arsenal of startling facts . . . Fast Food Nation points the way but, to resurrect an old fast food slogan, the choice is yours.”—Los Angeles Times

In 2001, Fast Food Nation was published to critical acclaim and became an international bestseller. Eric Schlosser’s exposé revealed how the fast food industry has altered the landscape of America, widened the gap between rich and poor, fueled an epidemic of obesity, and transformed food production... View Details


Fast Food
by Joost Elffers (Author), Saxton Freymann (Author), Saxton Freymann (Illustrator)

Fruits and vegetables leap off the plate and off the page in Saxton Freymann's fast-paced tribute to things that GO!

When you see piles of veggies lying sedately around the corner store, you'd never guess all that produce really wants to go, go, GO! But Saxton Freymann did, and he's transformed those basking berries and lazy legumes into vehicles of every size and speed. Kids everywhere will thrill over the array of transportation methods on display, from enormous rockets and grand ocean liners to the simplest mechanism of all: your feet. And as always, Freymann's clever vegetable... View Details


Fast Food Genocide: How Processed Food is Killing Us and What We Can Do About It
by Dr. Joel Fuhrman (Author), Robert Phillips (Author)

From the #1 New York Times bestselling author of Eat to Live and The End of Diabetes, an unflinching, provocative exploration of how our food is killing us and the ways in which we are unwitting participants in an unprecedented and exploding health crisis.

Fast food is far more than just the burgers, fries, and burritos served at chain restaurants; it is also the toxic, human-engineered products found in every grocery store across America. These include: cold breakfast cereals; commercial and preserved (deli) meats and cheeses; sandwich... View Details


Fast Food: The Good, the Bad and the Hungry (Food Controversies)
by Andrew F. Smith (Author)

The single most influential culinary trend of our time is fast food.  It has spawned an industry that has changed eating, the most fundamental of human activities. From the first flipping of burgers in tiny shacks in the western United States to the forging of neon signs that spell out “Pizza Hut” in Cyrillic or Arabic scripts, the fast food industry has exploded into dominance, becoming one of the leading examples of global corporate success. And with this success it has become one of the largest targets of political criticism, blamed for widespread obesity, cultural erasure, oppressive... View Details


100 Days of Real Food: Fast & Fabulous: The Easy and Delicious Way to Cut Out Processed Food
by Lisa Leake (Author)

In her first cookbook, 100 Days of Real Food, Lisa Leake revealed how simple it is to think out of the box in the kitchen by replacing unhealthy prepackaged and processed foods with “real food”—mouthwatering meals made with wholesome and familiar ingredients. Now, Lisa is back with 100 quick-and-easy recipes and simple cheat sheets that will work with every family’s busy lifestyle.

100 Days of Real Food: Fast & Fabulous gives Lisa’s devoted fans and newcomers exactly what they want, quick and tasty favorites for breakfast, lunch, dinner, dessert, and even... View Details


Great Food Fast : Bob Warden's Ultimate Pressure Cooker Recipes
by Bob Warden (Author)

New York Times and National Bestseller!
Few could boast having more expertise in pressure cookery than Bob Warden! He has introduced over 800,000 QVC customers to the convenience and deliciousness of cooking under pressure. In the twenty years he has been appearing as a guest cooking expert, Bob has helped develop hundreds of cooking products, including cookbooks. Now, Bob Warden's entirely new pressure cooking cookbook, Great Food Fast, looks to redefine pressure cooking all over again.

With the help of thousands of reader reviews, forum posts, and comments, Bob has... View Details


Fast Food Maniac: From Arby's to White Castle, One Man's Supersized Obsession with America's Favorite Food
by Jon Hein (Author)

The beloved personality from The Howard Stern Show celebrates American fast food, exploring the history and secret menu items of both national and regional chains, ranking everything from burgers and fries to ice and mascots, and offering his own expert tips on where to go and what to order. 
 
Jon Hein is the ultimate fast food maniac, and in this book he draws on his extensive knowledge of, and love for, both nationwide chains and regional gems, from McDonald’s and KFC to In-N-Out Burger and Carvel. He digs into their origin stories; reveals secret menu items;... View Details


Chew On This: Everything You Don't Want to Know About Fast Food
by Charles Wilson (Author), Eric Schlosser (Author)

Kids love fast food. And the fast food industry definitely loves kids. It couldn’t survive without them. Did you know that the biggest toy company in the world is McDonald’s? It’s true. In fact, one out of every three toys given to a child in the United States each year is from a fast food restaurant.

Not only has fast food reached into the toy industry, it’s moving into our schools. One out of every five public schools in the United States now serves brand name fast food. But do kids know what they’re eating? Where do fast food hamburgers come from? And what makes those... View Details


Real Food, Really Fast: Delicious Plant-Based Recipes Ready in 10 Minutes or Less
by Hannah Kaminsky (Author)

The promise of a hot, satisfying meal in ten minutes or less is no longer the exclusive calling card of cheap pizza delivery. Everything from dinners on the run to crave-worthy snacks for a crowd can be yours in less time than it takes to hunt down those crusty take-out menus. While most “quick-fix” recipes call for chemically enhanced mixes or unsavory prepared foods, Real Food, Really Fast cuts no corners when it comes to quality.

Inexpensive staples are reimagined with innovative flavor pairings, clever cooking techniques, and fun presentations, yielding all new delights such... View Details


Fast Food My Way
by Jacques Pépin (Author), Ben Fink (Photographer)

In Jacques Pépin Fast Food My Way, the man who taught millions of Americans how to cook shares the techniques he honed in the most famous kitchens of the world to show you how to create simple, special meals in minutes.
In this companion volume to his new series on public television, Jacques shows you how to create great-tasting dishes ranging from stunning salads such as Tomato and Mozzarella Fans to Supreme of Chicken with Balsamic Vinegar and Shallot Sauce to his breathtaking Almond Cake with Berries, all special enough for company, yet easy enough for those weekday evenings when you... View Details

Best Science Podcasts 2018

We have hand picked the best science podcasts for 2018. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

The Big Five
What are the five biggest global challenges we face right now — and what can we do about them? This hour, TED speakers explore some radical solutions to these enduring problems. Guests include geoengineer Tim Kruger, president of the International Rescue Committee David Miliband, political scientist Ian Bremmer, global data analyst Sarah Menker, and historian Rutger Bregman.
Now Playing: Science for the People

#457 Trowel Blazing
This week we look at some of the lesser known historical figures and current public perception of anthropology, archaeology, and other fields that end in "ology". Rebecca Wragg Sykes, an archaeologist, writer, and co-founder of the TrowelBlazers, tells us about the Raising Horizons project and how their team is trying to shine the spotlight on the forgotten historical women of archaeological, geological, and palaeontological science. And Kristina Killgrove, assistant professor of anthropology at the University of West Florida and science writer, talks about the public perception of the fields of anthropology and archeology, and how those science are represented -...