ESC Congress 2004: Diabetes mellitus in acute coronary syndromes - worse for women than for men

August 31, 2004

Diabetes is associated with worse prognosis in patients with myocardial infarction, but if there is a difference between men and women in this respect is less well known.

In an analysis of 10253 patients (3329 women) with a discharge diagnosis of acute coronary syndrome (myocardial infarction or unstable angina) in the Euro Heart Survey ACS. Of the women, 28% had DM and of the men 20%.

Compared to men without diabetes, men with diabetes tended to have less severe disease, that is less ST-elevation AMI (the form of myocardial infarction associated with the highest early mortality) and more unstable angina, a more benign form of acute coronary disease. This difference was largely due to the fact that men with diabetes more often had been hospitalised before with myocardial infarction and had more medications.

In women, the situation was different. Compared to women without diabetes, women with diabetes had more ST-elevation AMI and less unstable angina, after considering that diabetic women had more previous myocardial infarction and more medication.

Of the women with diabetes, 8.6% died in hospital, compared to 4.9% among women without diabetes with corresponding mortality rates among men with and without diabetes of 4.8% and 4.0%, respectively.

Conclusion: Diabetes in women with ACS is associated with higher risk of presenting with ST-elevation-ACS and of in-hospital mortality, whereas diabetes in men with ACS is not associated with increased risk of either. These findings suggest a differential effect of DM on the pathophysiology of ACS based on the patient's sex.
-end-
A Rosengren (Gothenburg, SE)

This press release accompanies both a presentation and an ESC press conference given at the ESC Congress 2004. Written by the investigator himself/herself, this press release does not necessarily reflect the opinion of the European Society of Cardiology

European Society of Cardiology

Related Diabetes Articles from Brightsurf:

New diabetes medication reduced heart event risk in those with diabetes and kidney disease
Sotagliflozin - a type of medication known as an SGLT2 inhibitor primarily prescribed for Type 2 diabetes - reduces the risk of adverse cardiovascular events for patients with diabetes and kidney disease.

Diabetes drug boosts survival in patients with type 2 diabetes and COVID-19 pneumonia
Sitagliptin, a drug to lower blood sugar in type 2 diabetes, also improves survival in diabetic patients hospitalized with COVID-19, suggests a multicenter observational study in Italy.

Making sense of diabetes
Throughout her 38-year nursing career, Laurel Despins has progressed from a bedside nurse to a clinical nurse specialist and has worked in medical, surgical and cardiac intensive care units.

Helping teens with type 1 diabetes improve diabetes control with MyDiaText
Adolescence is a difficult period of development, made more complex for those with Type 1 diabetes mellitus (T1DM).

Diabetes-in-a-dish model uncovers new insights into the cause of type 2 diabetes
Researchers have developed a novel 'disease-in-a-dish' model to study the basic molecular factors that lead to the development of type 2 diabetes, uncovering the potential existence of major signaling defects both inside and outside of the classical insulin signaling cascade, and providing new perspectives on the mechanisms behind insulin resistance in type 2 diabetes and possibly opportunities for the development of novel therapeutics for the disease.

Tele-diabetes to manage new-onset diabetes during COVID-19 pandemic
Two new case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in an adult and an infant during the COVID-19 pandemic.

Genetic profile may predict type 2 diabetes risk among women with gestational diabetes
Women who go on to develop type 2 diabetes after having gestational, or pregnancy-related, diabetes are more likely to have particular genetic profiles, suggests an analysis by researchers at the National Institutes of Health and other institutions.

Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).

Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.

People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.

Read More: Diabetes News and Diabetes Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.