Severe human infection with a novel avian-origin influenza A(H7N4) virus

August 31, 2018

Wild birds are believed to be the reservoir of influenza A viruses, and poultry may serve as a key intermedia in the cross-species avian influenza virus (AIV) transmission from wild birds to human. The backyard poultry, especially those locating in the flyway of migratory birds, is supposed to play a vital role in the introduction of wild bird AIVs. A novel reassortant AIV, influenza A(H7N4), has been identified in such a scenario, according to a new study published by Science Bulletin.

According to the epidemiological and laboratory investigations, the novel H7N4 virus originated from wild bird AIVs, infected backyard chickens and ducks and cause a severe human infection. A comprehensive investigation has been conducted on this case, confirming the viral infection and the transmission route. Early identification and response to this incident interrupted the spread of this novel virus.

The patient developed severe pneumonia after preceding influenza like illness. She finally responded to treatment with oseltamivir and ICU support. Based on the genome sequencing, the accountable novel virus is distinct from previously-reported avian H7N4 and H7N9 viruses. It is low pathogenic to avian, susceptible to antivirals and has binding preference of avian-like α2, 3-linked sialic acid receptor.

The symptomatic surveillance system and pathogen detection platform, including next generation sequencing, established in Jiangsu Provincial CDC play an important role in the early identification and early intervention on novel influenza viruses which could infect human.

"Threats from AIVs never stop. For early warning and preparedness regarding influenza pandemic, it is important to keep alert on the AIV infection of backyard poultry and feeders," the authors conclude.
This study was supported by grants from the National Science and Technology Major Project of China (2015ZX09101044), Science & Technology Demonstration Project for Emerging Infectious Diseases Control and Prevention of Jiangsu Province, China (BE2015714 & BE2017749) and Key Medical Discipline of Jiangsu Science & Technology Project of China (epidemiology, ZDXKA2016008).

See the article and highlight:

Huo Xiang, Cui Lun-biao, Chen Cong et al. Severe human infection with a novel avian-origin influenza A(H7N4) virus. Sci Bull, 2018, 63:1043-1050

Yuen KY. Another avian influenza A subtype jumping into human: this time is H7N4. Sci Bull, 2018, 63:1025-1026

Science China Press

Related Influenza Articles from Brightsurf:

Predicting influenza epidemics
Researchers at Linköping University, Sweden, have developed a unique method to predict influenza epidemics by combining several sources of data.

Common cold combats influenza
As the flu season approaches, a strained public health system may have a surprising ally -- the common cold virus.

Scent-sensing cells have a better way to fight influenza
Smell receptors that line the nose get hit by Influenza B just like other cells, but they are able to clear the infection without dying.

New antivirals for influenza and Zika
Leuven researchers have deployed synthetic amyloids to trigger protein misfolding as a strategy to combat the influenza A and Zika virus.

Assessment of deaths from COVID-19, seasonal influenza
Publicly available data were used to analyze the number of deaths from seasonal influenza deaths compared with deaths from COVID-19.

Obesity promotes virulence of influenza
Obesity promotes the virulence of the influenza virus, according to a study conducted in mice published in mBio, an open-access journal of the American Society for Microbiology.

Influenza: combating bacterial superinfection with the help of the microbiota
Frenc researchers and from Brazilian (Belo Horizonte), Scottish (Glasgow) and Danish (Copenhagen) laboratories have shown for the first time in mice that perturbation of the gut microbiota caused by the influenza virus favours secondary bacterial superinfection.

Chemists unveil the structure of an influenza B protein
MIT chemists have discovered the structure of an influenza B protein called BM2, a finding that could help researchers design drugs that block the protein and help prevent the virus from spreading.

How proteins help influenza A bind and slice its way to cells
Researchers have provided new insight on how two proteins help influenza A virus particles fight their way to human cells.

Eating elderberries can help minimize influenza symptoms
Conducted by Professor Fariba Deghani, Dr. Golnoosh Torabian and Dr.

Read More: Influenza News and Influenza Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to