Allergic reaction: How the immune system identifies nickel

August 31, 2020

The cause of the allergic reaction are T lymphocytes (T cells). These cells are part of the body's defences and normally react to viruses or bacteria in the skin. In the case of a nickel allergy, they also respond to electrically charged nickel atoms (ions) that can be released from nickel-containing products. These ions are then "identified" by the T cells in the form of a metal ion complex together with the body's own proteins. For explanation: Humans have a wide variety of T cells. Each of these T cells has unique docking sites (receptors) with which it can "identify" a very specific protein complex. The receptor consists both of variable subunits mainly concerned with the specific protein complex identification and of a selection of defined receptor segments. Together, the T cells have many millions of different receptors with which pathogens can be identified and combated with high precision (specific) in the event of an infection. The BfR researchers discovered peculiarities in human receptors that react to nickel ions. About 43 percent of the corresponding T cells have the amino acid histidine in the specific identification part of the docking site (i.e. the variable subunit of the receptor). This amino acid can bind to nickel ions. In addition, a surprisingly large number of human T cells with a certain additional "component", a defined receptor segment was identified. This is the case for around 35 percent of the T-cells that react to nickel ions. These findings are an important indicator of how the human immune system identifies nickel ions - and potentially represents an explanation for why people suffer from nickel allergy so often. The current findings were obtained using two new methods: The T-cells reacting to nickel ions were identified using an activation marker. At the same time, high-throughput sequencing de-tected many T-cell receptors. The benefits of the new results for medical practice cannot yet be assessed. So far, no differences in the receptors in the blood in allergic and non-allergic people have been detected. However, the BfR is working on extending the new methods to other allergens and applying them to T cells that are associated with allergies.
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Further information on the topic of nickel is available from the BfR website:

Summary page of all publications:

https://www.bfr.bund.de/en/a-z_index/nickel-130376.html

Contact allergy via nickel: Prize for BfR researcher

https://www.bfr.bund.de/cm/343/kontaktallergie-durch-nickel-preis-fuer-bfr-forscherin-katherina-siewert.pdf

About the BfR

The German Federal Institute for Risk Assessment (BfR) is a scientifically independent insti-tution within the portfolio of the Federal Ministry of Food and Agriculture (BMEL) in Germany. It advises the German federal government and German federal states ("Laender") on questions of food, chemical and product safety. The BfR conducts its own research on topics that are closely linked to its assessment tasks.

This text version is a translation of the original German text which is the only legally binding version.

BfR Federal Institute for Risk Assessment

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