Adolescents to benefit from launch of new migraine treatment

September 01, 2003

Thousands of adolescents (12-17 years of age) suffering with the misery of migraine headaches are set to benefit from the launch today of a new migraine treatment, ImigranTM (sumatriptan) 10mg Nasal Spray. Imigran 10mg Nasal Spray will be the first and only triptan (class of migraine treatment) specifically licensed for use in adolescents and will bring much-needed relief to those adolescents affected by this debilitating neurological condition. Imigran 10mg Nasal Spray has a fast and effective onset of action and Imigran 20mg Nasal Spray is already a well-established treatment for adults with migraine.

It is estimated that up to ten percent of adolescents are affected by migraine and as many as 2.75 million school days are lost each year as a result of migraine attacks in children and adolescents.(1) Migraine headaches in this age group can last between two and 48 hours(2) and in addition to the severe pain, symptoms may also include nausea, vomiting and intense sensitivity to light or noise.

Clinical studies have shown adolescent migraineurs to have raised levels of anxiety that can be attributed to their migraine attacks.(3) These migraine attacks can also be associated with considerable suffering, with adolescents often disabled due to feelings of helplessness, frustration and anger regarding their migraine.(4)

Ann Turner, Director of the Migraine Action Association said, "Migraine is not just a headache but a potentially debilitating neurological condition. Adolescents suffering from migraine attacks should seek help as doctors, nurse specialists and pharmacists are important allies in the battle against migraine and their advice and support can be invaluable. Although there is no cure for migraine, it is possible to bring the condition under control with the range of treatments now available and the introduction of a management programme tailored to each patient."

Migraine attacks may be associated with marked distress and functional disability (requiring absence from school) during adolescence.(3) These attacks also have the potential for significant impact on an adolescents' home and family activities and social interaction with friends.

Dr Manuela Fontebasso, General Practitioner and clinical assistant at the Headache Clinic at York District Hospital, said, "Historically, it has not been possible to routinely prescribe triptan medication to migraineurs of this age group. The introduction of new treatments such as Imigran for adolescents will be welcomed by both physicians and patients battling with this incapacitating condition. We look forward to Imigran 10mg Nasal Spray offering migraine patients in this age group, an improved outlook and quality of life."

GlaxoSmithKline, one of the world's leading research-based pharmaceutical and healthcare companies, is committed to improving quality of life by enabling people to do more, feel better and live longer.
1. Hartmaier SL, et al. Development of a brief 24-hour adolescent migraine functioning questionnaire. Headache 2001; 41: 150-156
2. International Headache Classification Committee. ICD-10 guide for headaches. International Headache Classification Committee.
Cephalalgia 1997; 17(suppl 19): 1-82 3. Smith MS, et al. Comparative study of anxiety, depression, somatization, functional disability and illness attribution in adolescents with chronic fatigue or migraine. Pediatrics April 2003; 111(4): 376-381
4. Cady RK, et al. Prevalence of headache in children. Headache 1996; 7: 312-318
5. Imigran 10mg Nasal Spray Summary of Product Characteristics

Shire Hall Communications

Related Migraine Articles from Brightsurf:

Disparities in migraine by sexual orientation
Survey data were used to examine the association between sexual orientation (exclusively heterosexual, mostly heterosexual, lesbian, gay or bisexual) and migraine.

Can you paint your migraine?
'Can you draw me a picture of your headache?' may sound like an unusual question - but drawings of headache pain provide plastic surgeons with valuable information on which patients are more or less likely to benefit from surgery to alleviate migraine headaches.

Acupuncture can reduce migraine headaches
Acupuncture can reduce migraine headaches compared to both sham (placebo) acupuncture and usual care, finds a new trial from China published by The BMJ today.

Migraine rats, medical facts
Migraine mechanisms are still far from being fully understood. Escalating data from animal models are 'fact-checking' the neurophysiological and behavioral correlates of the migraine experience in humans, and how they may be affected by current anti-migraine drugs or might translate into new therapies.

Connecting the dots in the migraine brain
This dMRI study pointed to the structural strengthening of connections involving subcortical regions associated with pain processing and weakening in connections involving cortical regions associated with hyperexcitability may coexist in migraine.

Predictors of chronic migraine
A review and meta-analysis found predictors of chronic migraine. Depression, high frequency attacks, medication overuse and allodynia increased the chances for new onset chronic migraine, while annual income -- US$ 50,000 showed a protective effect.

On nitroglycerin, cardiovascular homeostasis and...bam, migraine!
Researchers in Leiden, The Netherlands, found an exaggerated cardiovascular response to nitroglycerin infusion in migraine patients, suggesting an elevated systemic sensitivity to this compound in this population.

All roads lead to migraine
Dr. Samaira Younis, from the Danish Headache Center in Copenhagen, Denmark, shares her research results, which suggests there are no differences between migraine attacks clinical characteristics following administration of 2 different compounds in patients, CGRP and sildenafil, meaning they share common cellular signaling pathways.

Running away from exercise: The curious case of migraine
In spite of the widespread recommendation for regular physical activity as a strategy to manage migraine, for some patients, exercise can instead trigger migraine attacks.

Migraine prevention in children and adolescents
Two medicines already used to prevent migraine in adults also showed efficacy in adolescents with migraine.

Read More: Migraine News and Migraine Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to