Nav: Home

Childhood cholesterol, blood pressure, weight and smoking predict adult heart disease

September 01, 2019

Paris, France - 1 Sept 2019: The first reliable evidence of a link between major cardiovascular risk factors in children - serum cholesterol, blood pressure, body mass index (BMI), and smoking - with cardiovascular disease in adults is presented today at ESC Congress 2019 together with the World Congress of Cardiology.(1) The study highlights the need to lay the foundations for heart health early in life.

Study author Professor Terence Dwyer of the University of Oxford, UK, said: "While previous research has found connections between smoking and BMI in childhood and adult cardiovascular disease, there was no data for blood pressure or serum cholesterol. In addition, it has not been possible to assess the contributions of BMI and smoking while taking cholesterol and blood pressure into account."

The study used data from the International Childhood Cardiovascular Cohort (i3C) Consortium. Data was pooled on serum cholesterol, blood pressure, BMI, and smoking from seven child cohorts in the US, Australia, and Finland. Information was collected from 1971 onwards on approximately 40,000 children aged 3 to 19 who were followed up at around age 50 for cardiovascular events leading to hospitalisation (heart attack, stroke, peripheral arterial disease) or all-cause death.

Hazard ratios for cardiovascular events were calculated for each risk factor separately, and for all risk factors simultaneously. The latter analysis estimated how important each risk factor might be when all the others are taken into account.

For cardiovascular events leading to hospitalisation, the associations for risk factors were: (2)
  • BMI: 10% rise --> 20% higher risk of an event.

  • Systolic blood pressure: 10% rise --> 40% higher risk of an event.

  • Serum cholesterol: 10% rise --> 16% higher risk of an event.

  • Adolescent smoking --> 77% higher risk of an event.
In the simultaneous analysis of risk factors, the associations with future risk were reduced, suggesting a shared contribution to risk by each, although the smoking association remained relatively unchanged. The associations for death were very similar to those found for cardiovascular events.

Prof Dwyer said: "The study shows a very strong relationship between standard cardiovascular risk factors in children and the probability of a heart attack or stroke later in life. A meaningful proportion of that risk appears to be laid down in childhood and has a detrimental effect independent of adult risk factor levels. Programmes to prevent heart attacks and strokes should put more emphasis on promoting healthy lifestyles in children."
-end-
Notes to editors

Authors: ESC Press Office
Mobile: +33 (0) 7 8531 2036
Email: press@escardio.org

Follow us on Twitter @ESCardioNews

The hashtag for ESC Congress 2019 together with the World Congress of Cardiology is #ESCCongress

Funding: National Heart, Lung, and Blood Institute (NHLBI).

Disclosures: None.

References and notes

(1) The abstract "Childhood risk factors and cardiovascular disease outcomes in adulthood. Preliminary findings from the International Childhood Cardiovascular Cohort (i3C) Consortium" will be presented during:

* The press conference "Too young to die" on Sunday 1 September from 11:00 to 12:00 CEST.

* Lifestyle scores best on Sunday 1 September at 11:00 to 12:30 CEST in Science Box 2 - Poster Area.

(2) In the main analysis of the data, the researchers estimated hazard ratios for each standard deviation in the four exposures. However, for greater ease of interpretation for non-statisticians, the approximate percentage increase in hazard ratio for absolute change in the exposures are presented in the press release.

About ESC Congress

ESC Congress is the world's largest gathering of cardiovascular professionals contributing to global awareness of the latest clinical trials and breakthrough discoveries. ESC Congress 2019 together with the World Congress of Cardiology takes place from 31 August to 4 September at the Expo Porte de Versailles in Paris, France. Explore the scientific programme. http://spo.escardio.org/default.aspx?eevtid=1423

About the European Society of Cardiology

The European Society of Cardiology brings together health care professionals from more than 150 countries, working to advance cardiovascular medicine and help people lead longer, healthier lives.This press release accompanies both a presentation and an ESC press conference at ESC Congress 2019 together with the World Congress of Cardiology. It does not necessarily reflect the opinion of the European Society of Cardiology.

European Society of Cardiology

Related Blood Pressure Articles:

Do you really have high blood pressure?
A study by researchers at the University of Montreal Hospital Research Centre (CRCHUM) shows that more than half of family doctors in Canada are still using manual devices to measure blood pressure, a dated technology that often leads to misdiagnosis.
Why do we develop high blood pressure?
Abnormally high blood pressure, or hypertension, may be related to changes in brain activity and blood flow early in life.
For some, high blood pressure associated with better survival
Patients with both type 2 diabetes and acute heart failure face a significantly lower risk of death but a higher risk of heart failure-related hospitalizations if they had high systolic blood pressure on discharge from the hospital compared to those with normal blood pressure, according to a study scheduled for presentation at the American College of Cardiology's 66th Annual Scientific Session.
$9.4 million grant helps scientists explore how cell death from high blood pressure fuels even higher pressure
It's been known for decades that a bacterial infection can raise your blood pressure short term, but now scientists are putting together the pieces of how our own dying cells can fuel chronically high, destructive pressure.
Blood pressure diet improves gout blood marker
A diet rich in fruits, vegetables, low-fat dairy and reduced in fats and saturated fats (the DASH diet), designed decades ago to reduce high blood pressure, also appears to significantly lower uric acid, the causative agent of gout.
More Blood Pressure News and Blood Pressure Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Erasing The Stigma
Many of us either cope with mental illness or know someone who does. But we still have a hard time talking about it. This hour, TED speakers explore ways to push past — and even erase — the stigma. Guests include musician and comedian Jordan Raskopoulos, neuroscientist and psychiatrist Thomas Insel, psychiatrist Dixon Chibanda, anxiety and depression researcher Olivia Remes, and entrepreneur Sangu Delle.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...