Powerful tools from VTT to solve challenges in bio- and circular economy

September 03, 2018

VTT Technical Research Centre of Finland has developed an efficient synthetic biology toolbox for industry and research organisations. This toolbox enables, in an unprecedented way, engineering of a diverse range of yeasts and fungi. The toolbox comprises DNA parts which can be easily combined to create new biological systems.

The SES (Synthetic Expression System) toolbox enables expression of genes in yeasts and fungi considerably more efficiently and with better control than has been possible with previous methods. The toolbox is based on DNA components with well-defined functions and the components can be combined as if they were Lego bricks. In this way, molecular machines can be built, for example, for improved control of yeast cell performance in industrial bioprocesses for production of polymer precursors, fuels and medical compounds.

Because the components of the SES toolbox operate the same way in different species, they can be used to engineer species that have attractive properties, but which have due to lack of engineering tools not been studied or used in biotechnology applications in the past.

The SES toolbox is expected to enable development of numerous novel microbial production processes for valorization of various waste materials to higher value compounds. In doing so, the SES toolbox provides important solutions for bio- and circular economy challenges.
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Further information:

SES system publication in Nucleic Acids Research: https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gky558/5040049?guestAccessKey=92a53914-fa85-446c-8ff4-1bd30d11ddd5

Article on the opportunities offered by the SES toolkit and synthetic biology; VTT Impulse: http://www.vttresearch.com/Impulse/Pages/New-synthetic-biology-technologies-are-revolutionising-microbial-design.aspx

VTT Webinar: https://makingoftomorrow.com/the-future-of-biotech-a-universal-expression-system-to-meet-all-needs/

CONTACTS
VTT Technical Research Centre of Finland Ltd

Dominik Mojzita, Principal scientist
dominik.mojzita@vtt.fi tel. 358 40 359 1913

Jussi Jäntti, Research Team Leader
jussi.jantti@vtt.fi, tel. +358 50 522 7846

Further information on VTT:
Paula Bergqvist
Specialist, External Communications
+358 20 722 5161
paula.bergqvist@vtt.fi
http://www.vtt.fi

VTT Ltd is one of Europe's leading research, development and innovation organisations. We help our customers and society to grow and renew through applied research. The business sector and society in general benefit most from VTT when we solve challenges requiring world-class know-how together, and convert them into business opportunities. VTT in social media: Twitter @VTTFinland, Facebook, LinkedIn, YouTube and Instagram. For photos and videos, please visit our Image Bank.

VTT Technical Research Centre of Finland

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