Operation Outbreak simulation teaches students how pandemics spread

September 03, 2020

In 2015, a team of specialists in modeling disease outbreaks got together with educators to create Operation Outbreak, an educational platform and simulation intended to teach high school and college students the fundamentals of responses to pandemics. The program, which is open source and freely available, was designed to simulate outbreaks with different variables (such as R0 and mode of transmission) and to generate data in the context of real human behavior. It includes a Bluetooth-based app that carries out contact tracing by recording transmission events between phones. The details are highlighted in a Commentary published August 31 in the journal Cell.

Operation Outbreak came about after Todd Brown, then a middle school teacher in Florida, contacted Pardis Sabeti (@PardisSabeti), a computational biologist at the Broad Institute of Harvard and MIT, after reading a profile of her in a magazine. He and his students were studying the ongoing Ebola outbreak in West Africa, and he was developing a simulation of how the virus spread using stickers.

As they continued to work together, Sabeti and her team, including Andrés Colubri (@codeanticode), at the time a computational scientist in her lab, began studying mumps outbreaks across Boston college campuses. The idea to create an educational app that "spread" viruses through Bluetooth was soon born. And as recently as December 2019, they were running simulations modeling the outbreak of a virus with a very similar modus operandi to SARS-CoV-2.

"We decided to use a SARS-like virus since it had been high on many pandemic researchers' lists as a concern," says Colubri, who is now at the University of Massachusetts Medical School. "To make the simulation more challenging, we included an element of asymptomatic spread. This was a natural concern that would elevate a pandemic's potential even further."

This summer, as the COVID-19 pandemic continued to spread, Operation Outbreak was rolled out to 2,000 students in Chicago who were participating as "social distancing ambassadors" as part of the One Summer Chicago program. Participants used the app to track and trace behaviors and learn how "infections" spread in different parts of the city.

"The platform and curriculum are very flexible from an academic and also an experiential learning standpoint," Brown says. "We tried to gamify the education, so that players' behaviors and decisions affect not only them, but the entire group they're playing with."

The simulation includes elements that have become a familiar part of our daily lives, like limitations in testing abilities and shortages of personal protective equipment (PPE). The program also offers the ability to simulate additional elements that could arise in the current pandemic or in future ones, such as other circulating viruses that can complicate diagnosis.

"We are in one of the most unique situations in the history of the world, by virtue of being able to engage students," says Brown, who is now community outreach director at Sarasota Military Academy. "Kids are more primed to learn when something directly affects them and their families. This is a chance for future generations to become aware of how infections spread and to recognize warning signs."

"I hope we can convey that we don't have to wait for the next pandemic to learn how to respond to them," Sabeti says. "Ultimately, we can exquisitely model every aspect of viruses and how they spread, even in the ways that we react through vaccines, protective gear, and diagnostics."

The team has put together a scalable curriculum, including a textbook and series of educational videos, that can be integrated at schools around the country. The materials, which have been funded by philanthropy, are open source and are available for free.
-end-
This work is supported by the Gordon and Betty Moore Foundation and the Howard Hughes Medical Institute. Additional funding grants include L'Oreal USA Women in Science Changing the Face of STEM, Toshiba America Foundation, Florida Association of International Baccalaureate World Schools, and Voya Financial.

Cell, Colubri et al. "Preventing outbreaks through interactive, experiential real-life simulations" https://www.cell.com/cell/fulltext/S0092-8674(20)31084-9

Cell (@CellCellPress), the flagship journal of Cell Press, is a bimonthly journal that publishes findings of unusual significance in any area of experimental biology, including but not limited to cell biology, molecular biology, neuroscience, immunology, virology and microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. Visit: http://www.cell.com/cell. To receive Cell Press media alerts, contact press@cell.com.

Cell Press

Related Pandemic Articles from Brightsurf:

Areas where the next pandemic could emerge are revealed
An international team of human- and animal health experts has incorporated environmental, social and economic considerations -- including air transit centrality - to identify key areas at risk of leading to the next pandemic.

Narcissists love being pandemic 'essential workers'
There's one group of essential workers who especially enjoy being called a ''hero'' during the COVID-19 pandemic: narcissists.

COVID-19: Air quality influences the pandemic
An interdisciplinary team from the University of Geneva and the ETH Z├╝rich spin-off Meteodat investigated possible interactions between acutely elevated levels of fine particulate matter and the virulence of the coronavirus disease.

People who purchased firearms during pandemic more likely to be suicidal
People who purchase a firearm during the pandemic are more likely to be suicidal than other firearm owners, according to a Rutgers study.

Measles outbreaks likely in wake of COVID-19 pandemic
Major measles outbreaks will likely occur during 2021 as an unexpected consequence of the COVID-19 pandemic, according to a new academic article.

The COVID-19 pandemic: How US universities responded
A new George Mason University study found that the majority of university announcements occurred on the same day as the World Health Organization's pandemic declaration.

Researchers find evidence of pandemic fatigue
A new study from the USC Leonard Davis School of Gerontology shows that the behavioral responses to COVID-19 differed by age.

Excessive alcohol consumption during the COVID-19 pandemic
The full impact of COVID-19 on alcohol use is not yet known, but rates have been rising during the first few months of the pandemic.

How fear encourages physical distancing during pandemic
Despite guidelines plastered on the walls and floors of grocery and retail stores encouraging customers to maintain six-feet of physical distance during the pandemic, many do not.

COVID-19 pandemic and $16 trillion virus
This Viewpoint aggregates mortality, morbidity, mental health conditions, and direct economic losses to estimate the total cost of the pandemic in the US on the optimistic assumption that it will be substantially contained by the fall of 2021.

Read More: Pandemic News and Pandemic Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.