Why can Shuyusan treat corticosterone-induced impairment?

September 05, 2013

Synthetic antidepressants present a narrow spectrum and side effects following long-term application. Recently, medical practitioners have shown interest in the use of Chinese medicines for the treatment of diseases and in the adjustment of the human response to stress. Liping Chen and colleagues from Hainan Branch of Chinese PLA General Hospital have found in their preliminary studies that the Chinese herb Shuyusan, whose main constituent is jasminoidin, has been shown to protect SH-SY5Y cells against corticosterone-induced damage. A recent study reported in the Neural Regeneration Research (Vol. 8, No. 22, 2013) showed that 5 and 30 μg/mL Shuyusan-containing serum elevated the survival rate of SH-SY5Y cells, reduced Bax expression, increased Bcl-2 expression, markedly elevated brain-derived neurotrophic factor mRNA expression, and blocked cell apoptosis. Moreover, the effect of high-dose (30 μg/mL) Shuyusan-containing serum was more remarkable. These findings indicate that Shuyusan-containing serum appears to protect SH-SY5Y cells against corticosterone-induced impairment by adjusting the expression of apoptosis-associated proteins and brain-derived neurotrophic factor.
Article: " Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment," by Liping Chen1, Zhigao Sun2, Fawei Wang1, Chengyong Xu2, Miao Geng3, Hongyan Chen3, Dongmei Duan1 (1 Department of Traditional Chinese Medicine, Hainan Branch of Chinese PLA General Hospital, Sanya 572004, Hainan Province, China; 2 Department of Internal Medicine, Hainan Branch of Chinese PLA General Hospital, Sanya 572004, Hainan Province, China; 3 Institute of Geriatrics, General Hospital of Chinese PLA, Beijing 100853, China)

Chen LP, Sun ZG, Wang FW, Xu CY, Geng M, Chen HY, Duan DM. Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment. Neural Regen Res. 2013;8(22):2060-2068.

Contact: Meng Zhao
Neural Regeneration Research

Full text:http://www.sjzsyj.org/CN/article/downloadArticleFile.do?attachType=PDF&id=677

Neural Regeneration Research

Related Survival Rate Articles from Brightsurf:

Arrhythmia-free survival is indeed survival of the fittest
In a new study, investigators report that patients undergoing atrial fibrillation (AF) ablation, who are physically fit before the procedure, have a much higher chance of benefiting from the procedure and remaining in normal sinus rhythm.

Global tracking devices negatively affect the survival rate of sage-grouses
A new study in The Condor: Ornithological Applications finds that currently-available global positioning system (GPS) tracking devices, previously thought to not alter animal survival rates, can decrease greater sage-grouse survival.

Study: More aggressive treatments needed to improve 5-year survival rate for glioblastoma
Despite improvements in median and short-term survival rates for patients with glioblastoma, the most common brain tumor in adults, the percentage of patients achieving five-year survival remains low, according to new Mayo Clinic research.

New Mexico cancer patients have lower survival rate, study finds
Researchers at the Burrell College of Osteopathic Medicine (BCOM) have found that cancer patients in New Mexico have lower chances of survival when compared to the rest of the nation.

Getting fertilizer in the right place at the right rate
In-soil placement of phosphorus can decrease phosphorus loss in snowmelt runoff

High survival rate among children who have suffered from growth restriction
Almost all children live to see their eighteenth birthday despite a severe growth restriction, as long as they have survived their first month during infancy.

Liver transplant survival rate sees improvement among older adults
To learn more about older adults and liver transplants, a team of researchers studied information recorded by the Scientific Registry of Transplant Recipients (SRTR) from 2003 to 2016.

Emergency resuscitation device increases cardiac arrest survival rate, study reports
When paramedics resuscitated cardiac arrest patients with a new type of breathing tube, their patients were more likely to survive, according to a University of Texas Health Science Center at Houston-led study in today's JAMA.

Poliovirus therapy for recurrent glioblastoma has three year survival rate of 21 percent
A genetically modified poliovirus therapy developed at Duke Cancer Institute shows significantly improved long-term survival for patients with recurrent glioblastoma, with a three-year survival rate of 21 percent in a phase 1 clinical trial.

Overestimated mutation rate
At the start of the epidemic in West Africa, the Ebola virus did not change as rapidly as thought at the time.

Read More: Survival Rate News and Survival Rate Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.