No increased risk of miscarriage from folic acid supplements

September 06, 2001

N.B Please note that if you are outside North America the embargo for Lancet Press Material is 0001 Hours UK time Friday 7th September 2001.

Women who consume folic acid supplements around the time of conception are not at an increased risk of miscarriage, conclude authors of a population-based study published in this weke's issue of THE LANCET.

Although it is well known that folic acid supplements can reduce the risk of infant neural-tube defects (NTDs), its effects on other pregnancy outcomes are unclear; a previous study suggested that folic acid could increase the risk of miscarriage by up to 16%.

Jacqueline Gindler and colleagues from the Centers for Disease Control and Prevention, Atlanta, USA, and Peking University Health Sciences Center, China, studied Chinese women who had taken part in a folic-acid campaign to prevent infant NTDs and who had registered in this campaign before they became pregnant for the first time. The investigators assessed the risk for miscarriage among women who had confirmed pregnancies and who had or had not taken pills containing only 400 μg of folic acid before and during early pregnancy.

The overall rate of miscarriage was 9.1% (2155 of 23 806 women). The rates of miscarriage among women who had and had not taken folic acid pills before and during the first three months of pregnancy were 9% and 9.3%, respectively. Demographic data of the women and the average time at miscarriage were similar between the two groups.

Robert Berry (one of the investigators) comments: "In this population-based study of a cohort of women whose use of folic acid supplements while pregnant had been previously documented and who had been pregnant for the first time, we found no evidence that daily consumption of 400 μg of folic acid before and during early pregnancy influenced their risk for miscarriage."
Contact: Dr Robert J Berry, Centers for Disease Control and Prevention, National Center for Environment Health, Division of Birth Defects and Pediatric Genetics, 4770 Buford Highway Mailstop F-45, Atlanta GA 30341, USA; T) 1-770-488-3502; F) 1-770-488-7197; E) or CDC Media Relations Division; T) 1-404-639-3286.


Related Pregnancy Articles from Brightsurf:

COVID-19 has a prolonged effect for many during pregnancy
Symptoms for pregnant women with COVID-19 can be prolonged, lasting two months or longer for a quarter of the women who participated in a national study led by UC San Francisco and UCLA.

Relaxed through pregnancy
A group of researchers from Charité - Universitätsmedizin Berlin have been able to show that maternal psychological wellbeing during pregnancy has a positive effect on newborn infants.

Trajectories of antidepressant medication use during pregnancy
In an analysis of women who started pregnancy when taking antidepressant medications, investigators identified three trajectories of antidepressant dispensing during pregnancy: more than half stopped their treatment, a quarter maintained their treatment throughout pregnancy, and one-fifth discontinued it for a minimum of three months and then resumed it during the postpartum period.

Are women using e-cigarettes during preconception and/or pregnancy?
A new study of 1,365 racially/ethnically diverse, low-income pregnant women found that 4% reported e-cigarette use.

A better pregnancy test for whales
To determine whale pregnancy, researchers have relied on visual cues or hormone tests of blubber collected via darts, but the results were often inconclusive.

Cannabis use during pregnancy
The large health care system Kaiser Permanente Northern California provides universal screening for prenatal cannabis use in women during pregnancy by self-report and urine toxicology testing.

Questions and answers about cannabis use during pregnancy
A new study shows that women have many medical questions about the use of cannabis both before and during pregnancy, and during the postpartum period while breastfeeding.

The effect of taking antidepressants during pregnancy
Exposure to antidepressants during pregnancy and the first weeks of life can alter sensory processing well into adulthood, according to research in mice recently published in eNeuro.

Is ivermectin safe during pregnancy?
Is it safe to give ivermectin to pregnant women? To answer this question, researchers from the Barcelona Institute for Global Health (ISGlobal), an institution supported by 'la Caixa,' conducted a systematic review and meta-analysis of studies that reported cases of accidental exposure to the drug among pregnant women.

Going to sleep on your back in late pregnancy
This study looked at whether going to sleep on your back in the third trimester of pregnancy was associated with average lower birth weights.

Read More: Pregnancy News and Pregnancy Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to