Cockroach brains could be rich stores of new antibiotics

September 06, 2010

Cockroaches could be more of a health benefit than a health hazard according to scientists from The University of Nottingham.

Experts from the School of Veterinary Medicine and Science have discovered powerful antibiotic properties in the brains of cockroaches and locusts which could lead to novel treatments for multi-drug resistant bacterial infections. They found that the tissues of the brain and nervous system of the insects were able to kill more than 90 per cent of MRSA and pathogenic Escherichia coli, without harming human cells.

Simon Lee, a postgraduate researcher will present/presented their work at the Society for General Microbiology's autumn meeting which is being held at The University of Nottingham between the 6 and 9 September 2010. The research has identified up to nine different molecules in the insect tissues that were toxic to bacteria.

Simon Lee said: "We hope that these molecules could eventually be developed into treatments for E. coli and MRSA infections that are increasingly resistant to current drugs. These new antibiotics could potentially provide alternatives to currently available drugs that may be effective but have serious and unwanted side effects."

Dr Naveed Khan, an Associate Professor of Molecular Microbiology who is supervising Simon Lee's work said: "Superbugs such as MRSA have developed resistance against the chemotherapeutic artillery that we throw at them. They have shown the ability to cause untreatable infections, and have become a major threat in our fight against bacterial diseases. Thus, there is a continuous need to find additional sources of novel antimicrobials to confront this menace."

Using state-of-the-art analytical tools, Dr Khan and his team are studying the specific properties of the antibacterial molecules. Research is currently underway to test the potency of these molecules against a variety of emerging superbugs such as Acinetobacter, Pseudomonas and Burkholderia.

Mr Lee explained why it is unsurprising that insects secrete their own antimicrobials. He said: "Insects often live in unsanitary and unhygienic environments where they encounter many different types of bacteria. It is therefore logical that they have developed ways of protecting themselves against micro-organisms."
-end-


University of Nottingham

Related MRSA Articles from Brightsurf:

Widely available antibiotics could be used in the treatment of 'superbug' MRSA
Some MRSA infections could be tackled using widely-available antibiotics, suggests new research from an international collaboration led by scientists at the University of Cambridge and the Wellcome Sanger Institute.

Computer model shows how to better control MRSA outbreaks
A research team led by scientists at the Columbia University Mailman School of Public Health report on a new method to help health officials control outbreaks of methicillin-resistant Staphylococcus aureus, or MRSA, a life-threatening antibiotic-resistant infection often seen in hospitals.

Using MRSA's strength against it
MRSA evolved to become a deadly killer because it's wily and resilient.

Livestock-associated MRSAfound among MRSA from humans
The survey results show more frequent detections and geographical dispersion of LA-MRSA in humans in the EU/EEA since 2007, and highlight the public health and veterinary importance of LA-MRSA as a 'One Health' issue.

Fighting MRSA with new membrane-busting compounds
Public health officials are increasingly concerned over methicillin-resistant Staphylococcus aureus (MRSA).

Know thy enemy: Kill MRSA with tailored chemistry
UConn medicinal chemists have developed experimental antibiotics that kill MRSA, a common and often deadly bacteria that causes skin, lung, and heart infections.

MRSA uses decoys to evade a last-resort antibiotic
The superbug MRSA uses decoys to evade a last-resort antibiotic, reveals new research.

Scientists find a salty way to kill MRSA
Scientists have discovered a new way to attack Staphylococcus aureus bacteria.

Experimental antibiotic treats deadly MRSA infection
A new experimental antibiotic developed by a team of scientists at Rutgers University successfully treats the deadly MRSA infection and restores the efficacy of a commonly prescribed antibiotic that has become ineffective against MRSA.

OU team develops new antibiotic to fight MRSA
A University of Oklahoma team of chemists has developed a new antibiotic formulation to fight the sometimes deadly staph infection caused by methicillin-resistant S. aureus or MRSA and other antibiotic-resistant infectious bacteria.

Read More: MRSA News and MRSA Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.