Nav: Home

10 Cancer Moonshot Blue Ribbon Panel recommendations embraced by NCI

September 07, 2016

When 28 distinguished individuals convened earlier this year to help shape the scientific mission at the National Cancer Institute (NCI) of Vice President Joe Biden's National Cancer Moonshot Initiative, they were given five months to draft guidelines to accelerate cancer research, prevention and care. On Wednesday, the National Cancer Advisory Board approved the Blue Ribbon Panel's 10 recommendations.

"In a very limited amount of time we were able to come together to address important topics to help Vice President Biden's mission to make a decade's worth of advances in cancer prevention, diagnosis and treatment in just five years," said Blue Ribbon Panel member, María Elena Martínez, PhD, Sam M. Walton Endowed Chair for Cancer Research at University of California San Diego School of Medicine and co-lead of the Moores Cancer Center's Reducing Cancer Disparities research program. "My hope is that not just the National Cancer Institute, but other organizations and industry as well, take these recommendations to heart and contribute to moving these guidelines forward."

Martínez co-chaired the Implementation Science Working Group, which was tasked with drafting recommendations that improve cancer outcomes by identifying and testing methods that more effectively implement evidence-based interventions for cancer prevention, risk assessment, screening and early detection, and prognosis, treatment and survivorship.

"In some areas of cancer research, be it prevention or treatment, we actually have evidence of what works," said Martínez. "A lot of research goes behind these guidelines. In some populations, specifically those that do not have the means to get to a physician, to get to a hospital, who don't have health insurance, these guidelines don't get implemented. Some of it has to do with educating the community, making sure they are part of the implementation of these guidelines and that they're at the forefront of moving this forward."

The group recommended expanding use of proven prevention and early detection strategies to further address tobacco cessation, colorectal cancer screening, vaccination for the human papillomavirus (HPV) and screening for hereditary cancer syndromes. This recommendation has the potential to impact large populations through prevention strategies.

In the United States, only 50 to 60 percent of people are screened for colorectal cancer; the figure drops to 20 to 30 percent among low-income individuals, said Martínez. HPV vaccinations rates are worse, with only 40 percent of age-eligible girls and 20 percent of age-eligible boys completing the recommended vaccine dosage.

"The bold but feasible cross-cutting initiatives in this report will improve outcomes for patients with cancer, prevent cancer and increase our understanding of cancer," said Douglas Lowy, MD, NCI acting director. "NCI stands ready to accelerate cancer research in the critical areas identified by the Blue Ribbon Panel."

The final 10 Blue Ribbon Panel recommendations are:
  • Engage patients to contribute their comprehensive tumor profile data to expand knowledge about what therapies work, in whom, and in which types of cancer.
  • Establish a cancer immunotherapy clinical trials network devoted exclusively to discovering and evaluating immunotherapy approaches.
  • Identify therapeutic targets to overcome drug resistance through studies that determine the mechanisms that lead cancer cells to become resistant to previously effective treatments.
  • Create a national ecosystem for sharing and analyzing cancer data so that researchers, clinicians and patients will be able to contribute data, which will facilitate efficient data analysis.
  • Improve understanding of fusion oncoproteins in pediatric cancer and use new preclinical models to develop inhibitors that target them.
  • Accelerate the development of guidelines for routine monitoring and management of patient-reported symptoms to minimize debilitating side effects of cancer and its treatment.
  • Reduce cancer risk and cancer health disparities through approaches in development, testing and broad adoption of proven prevention strategies.
  • Predict response to standard treatments through retrospective analysis of patient specimens.
  • Create dynamic 3-D maps of human tumor evolution to document the genetic lesions and cellular interactions of each tumor as it evolves from a precancerous lesion to advanced cancer.
  • Develop new enabling cancer technologies to characterize tumors and test therapies.
-end-
About Moores Cancer Center at UC San Diego Health

Moores Cancer Center is one of only 45 National Cancer Institute-designated comprehensive cancer centers in the country. For adults newly diagnosed with cancer, treatment at an NCI-designated comprehensive cancer center means superior survival and recovery rates due to the fullness of care, diverse medical, surgical, and radiation oncology sub-specialties, access to breakthrough clinical trials, advanced supportive care and utilization of exacting quality metrics not offered in community settings.

Moores Cancer Center currently operates more than 170 open treatment trials. These investigational therapies include advanced, highly personalized stem cell-based approaches and immunotherapies that leverage the inherent healing powers of the human body.

In late-2016, UC San Diego Health will open Jacobs Medical Center, a 245-bed, 10-story facility where patients with cancer will have access to the Pauline and Stanley Foster Pavilion for Cancer Care, a space dedicated to specialized oncology.

University of California - San Diego

Related Cancer Articles:

Radiotherapy for invasive breast cancer increases the risk of second primary lung cancer
East Asian female breast cancer patients receiving radiotherapy have a higher risk of developing second primary lung cancer.
Cancer genomics continued: Triple negative breast cancer and cancer immunotherapy
Continuing PLOS Medicine's special issue on cancer genomics, Christos Hatzis of Yale University, New Haven, Conn., USA and colleagues describe a new subtype of triple negative breast cancer that may be more amenable to treatment than other cases of this difficult-to-treat disease.
Metabolite that promotes cancer cell transformation and colorectal cancer spread identified
Osaka University researchers revealed that the metabolite D-2-hydroxyglurate (D-2HG) promotes epithelial-mesenchymal transition of colorectal cancer cells, leading them to develop features of lower adherence to neighboring cells, increased invasiveness, and greater likelihood of metastatic spread.
UH Cancer Center researcher finds new driver of an aggressive form of brain cancer
University of Hawai'i Cancer Center researchers have identified an essential driver of tumor cell invasion in glioblastoma, the most aggressive form of brain cancer that can occur at any age.
UH Cancer Center researchers develop algorithm to find precise cancer treatments
University of Hawai'i Cancer Center researchers developed a computational algorithm to analyze 'Big Data' obtained from tumor samples to better understand and treat cancer.
New analytical technology to quantify anti-cancer drugs inside cancer cells
University of Oklahoma researchers will apply a new analytical technology that could ultimately provide a powerful tool for improved treatment of cancer patients in Oklahoma and beyond.
Radiotherapy for lung cancer patients is linked to increased risk of non-cancer deaths
Researchers have found that treating patients who have early stage non-small cell lung cancer with a type of radiotherapy called stereotactic body radiation therapy is associated with a small but increased risk of death from causes other than cancer.
Cancer expert says public health and prevention measures are key to defeating cancer
Is investment in research to develop new treatments the best approach to controlling cancer?
UI Cancer Center, Governors State to address cancer disparities in south suburbs
The University of Illinois Cancer Center and Governors State University have received a joint four-year, $1.5 million grant from the National Cancer Institute to help both institutions conduct community-based research to reduce cancer-related health disparities in Chicago's south suburbs.
Leading cancer research organizations to host international cancer immunotherapy conference
The Cancer Research Institute, the Association for Cancer Immunotherapy, the European Academy of Tumor Immunology, and the American Association for Cancer Research will join forces to sponsor the first International Cancer Immunotherapy Conference at the Sheraton New York Times Square Hotel in New York, Sept.

Related Cancer Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Anthropomorphic
Do animals grieve? Do they have language or consciousness? For a long time, scientists resisted the urge to look for human qualities in animals. This hour, TED speakers explore how that is changing. Guests include biological anthropologist Barbara King, dolphin researcher Denise Herzing, primatologist Frans de Waal, and ecologist Carl Safina.
Now Playing: Science for the People

#SB2 2019 Science Birthday Minisode: Mary Golda Ross
Our second annual Science Birthday is here, and this year we celebrate the wonderful Mary Golda Ross, born 9 August 1908. She died in 2008 at age 99, but left a lasting mark on the science of rocketry and space exploration as an early woman in engineering, and one of the first Native Americans in engineering. Join Rachelle and Bethany for this very special birthday minisode celebrating Mary and her achievements. Thanks to our Patreons who make this show possible! Read more about Mary G. Ross: Interview with Mary Ross on Lash Publications International, by Laurel Sheppard Meet Mary Golda...