Nav: Home

DOD grant explores new drugs to thwart impact of trauma, stroke, and cardiac arrest

September 07, 2016

A $2.3 million Department of Defense grant will help neuroscientists develop new treatments for the emergency room and the battlefield. The research will focus on the development of new therapies that could help protect brain and other at risk organs following a trauma, heart attack, or stroke.

"While we have made significant progress in our ability to restore blood flow after stroke or cardiac arrest, the medical community does not have drugs at its disposal to prevent the secondary damage that occurs after these events," said University of Rochester Medical Center neurologist Marc Halterman, M.D., Ph.D., the principal investigator of the study. "This grant will further our research on a promising class of drugs that possess both anti-inflammatory and cytoprotective properties that we believe will be suitable for use in both military and emergency conditions."

The project was developed in collaboration with a team of synthetic antibiotic chemists in Salt Lake City, led by Mark Nelson, Ph.D. who will serve as the principal investigator for the sub-award to Echelon Biosciences.

The new grant will enable Halterman and Nelson to synthesize and test drugs to protect the brain and other organs in the body from ischemia and reperfusion injury (IRI). When the body is subject to blunt trauma with acute blood loss, cardiac arrest or stroke, the direct cellular injury that occurs due to inadequate blood supply (ischemia) is often compounded by a delayed wave of tissue damage caused by the accumulation of free radicals and activation of the immune system which can continue long after the blood flow restarts (reperfusion).

When IRI occurs in the brain, heart, kidneys, and other susceptible organs, the damage can become permanent, debilitating, and potentially fatal. There are currently no effective drugs used to reduce the collateral damage caused by IRI.

Their research will focus on a family of antibiotic drugs called tetracyclines. While these drugs have been around for more than 60 years and are most commonly used to treat bacterial infections, they also possess potent anti-inflammatory and neuroprotective properties.

Halterman and Nelson have identified a compound that shows promise in preventing damage in tissue samples and animal models of stroke and cardiac arrest. This compound - designated EBI-2114 - is also highly stable, meaning it maintains its integrity and effectiveness even under adverse conditions, such as on a battlefield, during a natural disaster, or for emergency care. The compound will also be designed to be inactive against bacteria, sparing the patient of the possibility of developing antibiotic resistant infections.
-end-


University of Rochester Medical Center

Related Heart Attack Articles:

Where you live could determine risk of heart attack, stroke or dying of heart disease
People living in parts of Ontario with better access to preventive health care had lower rates of cardiac events compared to residents of regions with less access, found a new study published in CMAJ (Canadian Medical Association Journal).
Activated T-cells drive post-heart attack heart failure
Chronic inflammation after a heart attack can promote heart failure and death.
ICU care for COPD, heart failure and heart attack may not be better
Does a stay in the intensive care unit give patients a better chance of surviving a chronic obstructive pulmonary disease (COPD) or heart failure flare-up or even a heart attack, compared with care in another type of hospital unit?
Heart attack treatment might be in your face
Researchers at the University of Cincinnati have received $2.4 million in federal funding to pursue research on a novel cell therapy that would repair heart damage using modified cells taken from the patient's own facial muscle.
Tissue engineering advance reduces heart failure in model of heart attack
Researchers have grown heart tissue by seeding a mix of human cells onto a 1-micron-resolution scaffold made with a 3-D printer.
More Heart Attack News and Heart Attack Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Anthropomorphic
Do animals grieve? Do they have language or consciousness? For a long time, scientists resisted the urge to look for human qualities in animals. This hour, TED speakers explore how that is changing. Guests include biological anthropologist Barbara King, dolphin researcher Denise Herzing, primatologist Frans de Waal, and ecologist Carl Safina.
Now Playing: Science for the People

#534 Bacteria are Coming for Your OJ
What makes breakfast, breakfast? Well, according to every movie and TV show we've ever seen, a big glass of orange juice is basically required. But our morning grapefruit might be in danger. Why? Citrus greening, a bacteria carried by a bug, has infected 90% of the citrus groves in Florida. It's coming for your OJ. We'll talk with University of Maryland plant virologist Anne Simon about ways to stop the citrus killer, and with science writer and journalist Maryn McKenna about why throwing antibiotics at the problem is probably not the solution. Related links: A Review of the Citrus Greening...