Nav: Home

A microRNA signature for infantile hemangioma

September 08, 2016

Infantile hemangiomas (IH) are benign vascular tumors occurring in 4-5% of infants. These tumors resolve spontaneously or in response to propranolol treatment; however, they resemble other vascular anomalies and cannot be definitively diagnosed without biopsy. In this issue of JCI Insight, Jonathan Perkins of University of Washington and colleagues analyzed IH tumor tissue, IH patient plasma, and non-IH vascular anomalies to identify a set of microRNAs that are specific for IH. MicroRNAs are small RNA molecules that do not encode genes, but instead regulate the expression of other genes. The IH-specific set of microRNAs, known as C19MC, was specifically upregulated in IH tumor cells and was also detectable in IH patient plasma. Importantly, circulating C19MC microRNAs decreased in parallel with IH tumor regression, but rebounded with tumor re-growth. These results suggest that plasma C19MC microRNAs could be used to diagnose and monitor IH treatment. Additionally, C19MC microRNAs may be important in IH pathogenesis, as their known targets include genes encoding inhibitors of cell growth and proliferation.

TITLE:

Endothelial and circulating C19MC microRNAs are biomarkers of infantile hemangioma
-end-
AUTHOR CONTACT:

Jonathan Perkins
Seattle Children's Research Institute
Email: jonathan.perkins@seattlechildrens.org

View this article at:http://insight.jci.org/articles/view/88856?key=f843954190c60e07efa9

JCI Insight is the newest publication from the American Society of Clinical Investigation, a nonprofit honor organization of physician-scientists. JCI Insight is dedicated to publishing a range of translational biomedical research with an emphasis on rigorous experimental methods and data reporting. All articles published in JCI Insight are freely available at the time of publication. For more information about JCI Insight and all of the latest articles go to http://www.insight.jci.org.

JCI Journals

Related Plasma Articles:

How bacteria protect themselves from plasma treatment
Considering the ever-growing percentage of bacteria that are resistant to antibiotics, interest in medical use of plasma is increasing.
A breakthrough in the study of laser/plasma interactions
Researchers from Lawrence Berkeley National Laboratory and CEA Saclay have developed a particle-in-cell simulation tool that is enabling cutting-edge simulations of laser/plasma coupling mechanisms.
Researchers turn liquid metal into a plasma
For the first time, researchers at the University of Rochester's Laboratory for Laser Energetics (LLE) have found a way to turn a liquid metal into a plasma and to observe the temperature where a liquid under high-density conditions crosses over to a plasma state.
How black holes power plasma jets
Cosmic robbery powers the jets streaming from a black hole, new simulations reveal.
Give it the plasma treatment: strong adhesion without adhesives
A Japanese research team at Osaka University used plasma treatment to make fluoropolymers and silicone resin adhere without any adhesives.
Chemotherapeutic drugs and plasma proteins: Exploring new dimensions
This review provides a bird's eye view of interaction of a number of clinically important drugs currently in use that show covalent or non-covalent interaction with serum proteins.
The coming of age of plasma physics
The story of the generation of physicists involved in the development of a sustainable energy source, controlled fusion, using a method called magnetic confinement.
Intense microwave pulse ionizes its own channel through plasma
More than 30 years ago, researchers theoretically predicted the ionization-induced channeling of an intense microwave beam propagating through a neutral gas (>103 Pa) -- and now it's finally been observed experimentally.
Plasma thruster: New space debris removal technology
A Japanese and Australian research group has discovered new technology to remove space debris using a single propulsion system in a helicon plasma thruster.
Separating the sound from the noise in hot plasma fusion
For fusion power plants to be effective, scientists must find a way to trigger the low-to-high confinement transition, associated with zonal flows of plasma.
More Plasma News and Plasma Current Events

Top Science Podcasts

We have hand picked the top science podcasts of 2019.
Now Playing: TED Radio Hour

In & Out Of Love
We think of love as a mysterious, unknowable force. Something that happens to us. But what if we could control it? This hour, TED speakers on whether we can decide to fall in — and out of — love. Guests include writer Mandy Len Catron, biological anthropologist Helen Fisher, musician Dessa, One Love CEO Katie Hood, and psychologist Guy Winch.
Now Playing: Science for the People

#543 Give a Nerd a Gift
Yup, you guessed it... it's Science for the People's annual holiday episode that helps you figure out what sciency books and gifts to get that special nerd on your list. Or maybe you're looking to build up your reading list for the holiday break and a geeky Christmas sweater to wear to an upcoming party. Returning are pop-science power-readers John Dupuis and Joanne Manaster to dish on the best science books they read this past year. And Rachelle Saunders and Bethany Brookshire squee in delight over some truly delightful science-themed non-book objects for those whose bookshelves are already full. Since...
Now Playing: Radiolab

An Announcement from Radiolab