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BioMILD trial demonstrates lung cancer screening using MicroRNA blood test enhances prevention

September 09, 2019

Barcelona--Lung cancer screening efforts have accelerated in the last decade, with researchers showing that low dose CT screening is effective in reducing lung cancer mortality. Now, researchers in Milan report that using a blood test, accompanied by low dose CT screening, is safe and effective. The results were shared today at the IASLC 2019 World Conference on Lung Cancer hosted by the International Association for the Study of Lung Cancer.

The National Lung Screening Trial (NLST) showed that lung cancer screening by three annual rounds of low-dose computed tomography (LDCT) reduced lung cancer mortality. The Multicentric Italian Lung Detection (MILD) provided additional evidence that extended intervention beyond five years, with annual or biennial rounds, enhanced the benefit of low-dose CT screening.

Ugo Pastorino, MD, of the Istituto Nazionale dei Tumori Foundation and the lead researcher on the MILD trial, reports on results from a new trial, the bioMILD trial, which tested the additional value of blood microRNA assay at the time of LDCT on a large number of volunteers, with the aim of targeting next LDCT intervals on the basis of individual risk profile.

The bioMILD trial prospectively enrolled 4,119 volunteers at Istituto Nazionale Tumori of Milan with the median age of 60 years, median pack-years 42, current smokers 79% and females 39%. At the end of March 2019, a total of 11,012 LDCTs and 9,156 miRNA tests were performed, with an overall compliance at the 3-year LDCT of 93% and a median follow-up 4.2 years.

Pastorino had previously reported that that microRNA expression profiles in tumors and, for the first time, also in normal lung tissue, are indicative of aggressive lung cancer development and that specific microRNA signatures can be identified in plasma samples of patients up to two years before spiral-CT detection of the disease.

The BioMILD trial offered a lung cancer screening program combining LDCT and blood microRNA assay to heavy smokers (current or former ?10 years) aged 50-75 years. At baseline, LDCT and miRNA were tested independently with blind evaluation. According to LDCT and miRNA profile, different screening intervals were chosen for the following repeats, and participants with double negative LDCT and miRNA were sent to a 3-year interval.

Preliminary analysis showed a significantly higher lung cancer incidence and overall mortality in subjects with positive LDCT and/or miRNA at baseline. No detrimental effects on stage I lung cancer proportion, resection rates, or interval cancer incidence were observed in the group of subjects sent to 3-year LDCT repeat. Sensitivity and specificity analyses of LDCT and miRNA at baseline and subsequent screening rounds will be presented.

"BioMild showed that the combination of microRNA assay and LDCT is a valuable and safe tool to assess individual risk profile and reduce unnecessary LDCT repeats in lung cancer screening," said Dr. Pastorino.
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About the WCLC:

The WCLC is the world's largest meeting dedicated to lung cancer and other thoracic malignancies, attracting more than 7,000 researchers, physicians and specialists from more than 100 countries. The goal is to increase awareness, collaboration and understanding of lung cancer, and to help participants implement the latest developments across the globe. The conference will cover a wide range of disciplines and unveil several research studies and clinical trial results. For more information, visit wclc2019.iaslc.org.

About the IASLC:

The International Association for the Study of Lung Cancer (IASLC) is the only global organization dedicated solely to the study of lung cancer and other thoracic malignancies. Founded in 1974, the association's membership includes more than 6,500 lung cancer specialists across all disciplines in over 100 countries, forming a global network working together to conquer lung and thoracic cancers worldwide. The association also publishes the Journal of Thoracic Oncology, the primary educational and informational publication for topics relevant to the prevention, detection, diagnosis and treatment of all thoracic malignancies. Visit http://www.iaslc.org for more information.

International Association for the Study of Lung Cancer

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