$1.3 million NIH grant awarded to Florida Tech chemistry professor

September 12, 2005

MELBOURNE, FL - Dr. Joshua Rokach, Florida Tech Chemistry Professor and Director of the Claude Pepper Institute, has been awarded a four-year $1.3 million research grant from the National Institutes of Health (NIH). The grant from the National Heart, Lung, and Blood Institute will allow Dr. Rokach to continue his studies on chronic inflammatory diseases.

Rokach's research will focus on the enzymatic reaction of 5-hydroxyeicosanoid dehydrogenase in certain types of white blood cells, or leukocytes, which contributes to such diseases as asthma, inflammatory bowel disease and psoriasis. The research will center on the design and synthesis of radio- and photo-affinity ligand molecules that can bind to the enzyme catalytic cavity. Such molecules, when irradiated with ultraviolet light, become permanently bound to the disease-causing enzyme but not to other proteins. When the enzyme is radioactively labeled, it is possible to isolate and determine its structure.

Rokach has received worldwide recognition for the first syntheses of major inflammatory mediators such as leukotrienes and lipoxins, which are responsible for allergies affecting the lungs and nose. The availability of these synthetic mediators has opened the field to medical research in the areas of allergy and inflammation. Among his other accomplishments, Rokach was responsible for the development of the drug "Singulair", a leukotriene-D4 antagonist, used by millions of allergy sufferers for the relief of asthma and rhinitis symptoms.

Florida Institute of Technology

Related Asthma Articles from Brightsurf:

Breastfeeding and risks of allergies and asthma
In an Acta Paediatrica study, exclusive breastfeeding for the first 3 months was linked with a lower risk of respiratory allergies and asthma when children reached 6 years of age.

Researchers make asthma breakthrough
Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma.

Physics vs. asthma
A research team from the MIPT Center for Molecular Mechanisms of Aging and Age-Related Diseases has collaborated with colleagues from the U.S., Canada, France, and Germany to determine the spatial structure of the CysLT1 receptor.

New knowledge on the development of asthma
Researchers at Karolinska Institutet in Sweden have studied which genes are expressed in overactive immune cells in mice with asthma-like inflammation of the airways.

Eating fish may help prevent asthma
A scientist from James Cook University in Australia says an innovative study has revealed new evidence that eating fish can help prevent asthma.

Academic performance of urban children with asthma worse than peers without asthma
A new study published in Annals of Allergy, Asthma and Immunology shows urban children with poorly controlled asthma, particularly those who are ethnic minorities, also suffer academically.

Asthma Controller Step Down Yardstick -- treatment guidance for when asthma improves
The focus for asthma treatment is often stepping up treatment, but clinicians need to know how to step down therapy when symptoms improve.

Asthma management tools improve asthma control and reduce hospital visits
A set of comprehensive asthma management tools helps decrease asthma-related visits to the emergency department, urgent care or hospital and improves patients' asthma control.

Asthma linked to infertility but not among women taking regular asthma preventers
Women with asthma who only use short-acting asthma relievers take longer to become pregnant than other women, according to research published in the European Respiratory Journal.

What are the best ways to diagnose and manage asthma?
A team of experts from The University of Texas Medical Branch at Galveston examined the current information available from many different sources on diagnosing and managing mild to moderate asthma in adults and summarized them.

Read More: Asthma News and Asthma Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.