Nav: Home

Endometriosis increases risk of complications during pregnancy and delivery

September 13, 2017

(PHILADELPHIA) - A new meta-analysis shows that pregnant women with endometriosis are at greater risk for a host of complications during pregnancy and at delivery, including preterm birth and cesarean section. The study was published in the journal Fertility and Sterility.

"It's important that women with a history of endometriosis, and obstetricians caring for them, are aware of this association between prior endometriosis and higher risks of miscarriage, preterm birth, placenta previa, cesarean delivery and a baby small for gestational age," Vincenzo Berghella, M.D., Professor of Gynecology and Director of Maternal Fetal Medicine in the Department of Obstetrics and Gynecology at the Sidney Kimmel Medical College at Thomas Jefferson University. "These pregnancies deserve closer monitoring for these complications."

Endometriosis affects about 11 percent of women in the United States, is often diagnosed in the early reproductive years and is associated with endometrial tissue that travels and lodges in other parts of the body. Some of the symptoms include dagger-like abdominal pain, infertility and painful intercourse.

"Endometriosis is known to alter a woman's physiology in a way that could interfere with a number of stages of pregnancy," says Berghella. "From causing inflammation at the endometrium, to resisting the action of progesterone during implantation and throughout the pregnancy, there are a number of ways that endometriosis may affect the normal course of pregnancy."

Twenty four studies were included in the analysis comprising over a million women. The results show that women had a higher risk of preterm birth, miscarriage, cesarean delivery and placenta previa. The study also showed that endometriosis was associated with birth of infants who were small for their gestational age. There was no association, however, between endometriosis and gestational hypertension or preeclampsia.

"Prior studies looking at this issue have reported conflicting results," says Berghella. "Studies like ours help clarify the findings by pooling the data from many studies to give the field a more conclusive answer to a debated research question. The collective data is stronger than any single study alone and often helps shape opinion in the field."
-end-
Article reference: F. Zullo et al., "Endometriosis and obstetrics complications: a systematic review and meta-analysis," Fertility and Sterility, doi.org/10.1016/j.fertnstert.2017.07.019, 2017.

Thomas Jefferson University

Related Preterm Birth Articles:

Makeup of vaginal microbiome linked to preterm birth
In a study of predominantly African-American women -- who have a much higher rate of delivering babies early compared with other racial groups -- researchers at Washington University School of Medicine in St.
Preterm birth linked to higher risk of heart failure
Babies born preterm run a higher risk of heart failure during childhood and adolescence than those born at full term, researchers at Karolinska Institutet in Sweden report.
Low accuracy found for tests used to predict risk of spontaneous preterm birth for women who have not given birth before
The use of two measures, fetal fibronectin (a protein) levels and transvaginal cervical length, had low predictive accuracy for spontaneous preterm birth among women who have not given birth before, according to a study appearing in the March 14 issue of JAMA.
Study describes potential clinical test and treatment for preterm birth
Scientists identified a molecular driver of inflammation that may finally answer a key question about what causes mild systemic prenatal infections to trigger preterm birth.
Vaginal progesterone reduces the rate of preterm birth
Treatment with vaginal progesterone reduced the risk of preterm birth, neonatal complications and death in pregnant women with twins and who have a short cervix -- a risk factor for preterm birth -- according to a meta-analysis of individual patient data by researchers at the National Institutes of Health, the Wayne State University School of Medicine, the Detroit Medical Center, and other institutions in the United States and abroad.
Too little food from animal sources may increase risk of preterm birth
Pregnant women increase their chances of vitamin B12 deficiency if they don't consume enough meat, milk or eggs.
Bacterial membrane vesicles can cause preterm birth
A study published on Sept. 1 in PLOS Pathogens reports that GBS produces membrane-bound vesicles containing bacterial factors that can attack the host tissue.
Study quantifies risk factors for preterm birth
A significant portion of preterm births might be avoided by reducing or eliminating three major risk factors: abnormalities in the interval between pregnancies, the mother's body mass index prior to pregnancy, and the amount of weight gain in pregnancy.
Surgical stitch linked to stillbirth and preterm birth
In a study of almost 700 pregnant women who received a cervical stitch designed to prevent preterm labor, the use of one type of suture over another was associated with three times higher risk of stillbirth and almost twice the risk of preterm birth.
Common diabetes drug may help prevent preterm birth
Metformin, a medication routinely used by millions of people with type 2 diabetes, may also play an unexpected role in blocking a significant cause of preterm birth.

Related Preterm Birth Reading:

Neurodevelopmental Outcomes of Preterm Birth: From Childhood to Adult Life (Cambridge Medicine (Hardcover))
by Chiara Nosarti (Editor), Robin M. Murray (Editor), Maureen Hack (Editor)

The improved survival of very preterm and very low birth weight infants in recent decades has been associated with an increase in the prevalence of physical and neurodevelopmental problems. Attention is increasingly being focused on the quality of life of survivors, who are at greater risk of brain damage and consequent neurological disorders, and neuropsychological and behavioural impairments. In this volume, leading experts present a comprehensive and up-to-date perspective on research in various aspects of the long-term consequences of very preterm birth. As well as extending existing... View Details


Preterm Birth in the United States: A Sociocultural Approach
by Janet M. Bronstein (Author)

This first-of-its-kind volume addresses the myriad of issues relating to―and reviews the plethora of responses to--premature births in the United States, both in national context and compared with other countries. In addition to current clinical data, it examines how preterm births in the U.S. fit in with larger social concerns regarding poverty, racial disparities, reproductive rights, gender expectations, and the business of health care. Comparisons with preterm birth phenomena in Canada, the U.K., and other Western European countries illustrate cultural narratives about motherhood,... View Details


Preterm Birth: Causes, Consequences, and Prevention
by Institute of Medicine (Author), Board on Health Sciences Policy (Author), Committee on Understanding Premature Birth and Assuring Healthy Outcomes (Author), Adrienne Stith Butler (Editor), Richard E. Behrman (Editor)

The increasing prevalence of preterm birth in the United States is a complex public health problem that requires multifaceted solutions. Preterm birth is a cluster of problems with a set of overlapping factors of influence. Its causes may include individual-level behavioral and psychosocial factors, sociodemographic and neighborhood characteristics, environmental exposure, medical conditions, infertility treatments, and biological factors. Many of these factors co-occur, particularly in those who are socioeconomically disadvantaged or who are members of racial and ethnic minority... View Details


Preterm Birth: Prevention and Management
by Vincenzo Berghella (Editor)

Preterm birth is an increasing challenge in the developed and developing world.

As we begin to understand what contributes to the likelihood of preterm birth, obstetricians and gynecologists can advise mothers and aspiring mothers on how to minimize the risks. Doctors can also monitor those patients who are likely to be at risk to increase the chances of preventing or effectively managing preterm labor.

This practical book provides a clinically focused approach to the prevention and management of premature births, using the best available evidence to provide clear guidance to... View Details


Your Pregnancy and Childbirth: Month to Month, Sixth Edition
by American College of Obstetricians and Gynecologists (Author)

Based on ACOG guidelines and written by the experts in women's health care, this new edition of Your Pregnancy and Childbirth: Month to Month gives your patients the most accurate information available about pregnancy, childbirth, labor and delivery, breastfeeding, and the postpartum period. Key features include the following: Practical, straightforward advice about diet, exercise, prenatal visits and tests, and handling the discomforts of pregnancy Evidence-based guidance in making important decisions about issues such as pain management during labor, VBAC, and circumcision Separate sections... View Details


Expecting 411: The Insider's Guide to Pregnancy and Childbirth
by Michele Hakakha (Author), Ari Brown (Author)

Congratulations! You’re pregnant! Now, where do you turn to for the best advice? What if you could bottle the wisdom of all those women who came before you—and combine it with the solid medical advice from a renowned Beverly Hills’ OB/GYN and nationally known pediatrician? Expecting 411 is the answer: smart, up-to-date and refreshingly free of paranoia, this is the book you’ll turn to for quick answers to your most pressing questions. Inside, you'll find:

Is this normal? From morning sickness to stretch marks, you’ll learn what’s expected—and what’s... View Details


Oxorn Foote Human Labor and Birth, Sixth Edition
by Glenn David Posner (Author), Amanda Y. Black (Author), Griffith David Jones (Author), Jessica Dy (Author)

THE CLASSIC CHILDBIRTH HANDBOOK--COMPLETELY REVISED AND UPDATED IN FULL COLOR

A Doody's Core Title for 2017!

Edition after acclaimed edition, Oxorn-Foote Human Labor & Birth has provided the most comprehensive, yet accessible overview of obstetrics available. Going beyond scientific theory and a technological orientation, this landmark guide is written for the real world of clinical practice, as it expertly examines all mechanisms of human labor and delivery.

The book begins with a valuable review of clinical anatomy, then thoroughly examines the three... View Details


ABC of Preterm Birth (ABC Series)
by BMJ Books

Preterm birth is a major challenge in perinatal health care. Most perinatal deaths occur in preterm infants, and preterm birth is an important risk factor for neurological damage, including cerebral palsy. This ABC covers all the latest information on this complex and multidisciplinary area from obstetric issues to immediate care of preterm infants, respiratory complications, and how to provide support to the parents and relatives of the preterm infant.

With its clear explanation and many illustrations, general practitioners, medical students, paediatricians starting their postgraduate... View Details


Our NICU Journey
by Trish Ringley (Author), Trish Ringley (Contributor)

A brand new journal for tracking your baby's daily activities and statistics in the NICU

(Look inside the book coming soon!)

Our NICU Journey is the brand new NICU Journal from Every Tiny Thing. This high-quality baby book is the perfect place to track everything going on in your baby's daily life while in the NICU, including places to track:

・Date

・Weight

・Bonding Activities for the day

・Nurses, Doctors & Caregivers for the day

・Feedings

・Vital signs, labs, meds, procedures, equipment... View Details


Developmental and Therapeutic Interventions in the NICU
by Elsie Vergara "Sc.D. OTR FAO" (Author), Rosemarie Bigsby "Sc.D. OTR FAO" (Author)

The most comprehensive book available on neonatal intervention, this in-depth resource gives professionals the strong foundation of clinical knowledge they'll need to work with high-risk newborns. With a unique developmental and therapeutic perspective that sets it apart from other texts on the subject, the book is filled with research findings and practical guidelines clinicians will use to promote the well-being of infants in the NICU and to involve and support their families. In-service and preservice professionals will benefit from

an exploration of different developmental models... View Details

Best Science Podcasts 2017

We have hand picked the best science podcasts for 2017. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Simple Solutions
Sometimes, the best solutions to complex problems are simple. But simple doesn't always mean easy. This hour, TED speakers describe the innovation and hard work that goes into achieving simplicity. Guests include designer Mileha Soneji, chef Sam Kass, sleep researcher Wendy Troxel, public health advocate Myriam Sidibe, and engineer Amos Winter.
Now Playing: Science for the People

#448 Pavlov (Rebroadcast)
This week, we're learning about the life and work of a groundbreaking physiologist whose work on learning and instinct is familiar worldwide, and almost universally misunderstood. We'll spend the hour with Daniel Todes, Ph.D, Professor of History of Medicine at The Johns Hopkins University, discussing his book "Ivan Pavlov: A Russian Life in Science."