Does brain tissue regeneration depend on maturity of stem cells used for transplantation?September 13, 2017
New Rochelle, NY, September 13, 2017--New research has shown that the success of transplanting stem cells into the brain to regenerate tissue damaged by stroke may depend on the maturity of the neuronal precursor cells used for transplantation. A study demonstrating the significant impact of human neuronal precursor cell maturity on cell survival after transplantation into stroke-injured rate brains is published in Tissue Engineering, Part A, (http://online.liebertpub.com/tea) peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Tissue Engineering website until October 13, 2017.
Coauthors Samantha Payne, Priya Anandakumaran, Cindi Morshead, and Molly Shoichet, University of Toronto and Balazs Varga and Andras Nagy, Mount Sinai Hospital, Toronto, Canada, evaluated the survival of three subpopulations of human induced pluripotent stem cell (iPC)-derived neuronal precursor cells: early-, mid-, and late-differentiated cells. Significantly more early- and mid-differentiated neuronal stem cells were present in the rat brains one week after transplantation compared to late-differentiated cells. Furthermore, the mid-differentiated cells were the most likely to mature and become neurons, according to the results reported in the article entitled "In Vitro Maturation of Human iPSC-Derived Neuroepithelial Cells Influences Transplant Survival in the Stroke-Injured Rat Brain."
"Temporality as a variable in tissue engineering has rarely been explored. This is an excellent addition to our understanding of cell behavior in a therapeutic circumstance," says Tissue Engineering Co-Editor-in-Chief Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC.
Tissue Engineering is an authoritative peer-reviewed journal published monthly online and in print in three parts: Part A, the flagship journal published 24 times per year; Part B: Reviews, published bimonthly, and Part C: Methods, published 12 times per year. Led by Co-Editors-In-Chief Antonios G. Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX, and Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC, the Journal brings together scientific and medical experts in the fields of biomedical engineering, material science, molecular and cellular biology, and genetic engineering. Leadership of Tissue Engineering Part B (Reviews) and Part C (Methods) is provided by John P. Fisher, PhD, University of Maryland and John A. Jansen, DDS, PhD, Radboud University, respectively. Complete tables of content and a sample issue may be viewed online at the Tissue Engineering website. Tissue Engineering is the official journal of the Tissue Engineering & Regenerative Medicine International Society (TERMIS).
About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Stem Cells and Development, Human Gene Therapy, and Advances in Wound Care. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.
Mary Ann Liebert, Inc./Genetic Engineering News
Related Brain Articles:
Researchers compared the thickness of brain cortex in patients with brain tumors before and after radiation therapy was applied and found significant dose-dependent changes in the structural properties of cortical neural networks, at both the local and global level.
Using a sophisticated type of mathematics in a way that it has never been used before in neuroscience, a team from the Blue Brain Project has uncovered a universe of multi-dimensional geometrical structures and spaces within the networks of the brain.
Researchers have developed a new device to map the brain during surgery and distinguish between healthy and diseased tissues.
Scientists have today published ground-breaking scans of newborn babies' brains which researchers from all over the world can download and use to study how the human brain develops.
A new test using peripheral vision reaction time could lead to earlier diagnosis and more effective treatment of mild traumatic brain injury, often referred to as a concussion.
Religious and spiritual experiences activate the brain reward circuits in much the same way as love, sex, gambling, drugs and music, report researchers at the University of Utah School of Medicine.
'Practice makes perfect' is a common saying. We all have experienced that the initially effortful implementation of novel tasks is becoming rapidly easier and more fluent after only a few repetitions.
A team of scientists has extended the balanced network model to provide deep and testable predictions linking brain circuits to brain activity.
Spikes in neuronal activity in young mice do not spur corresponding boosts in blood flow -- a discovery that stands in stark contrast to the adult mouse brain.
The brains of teenagers with serious antisocial behavior problems differ significantly in structure to those of their peers, providing the clearest evidence to date that their behavior stems from changes in brain development in early life, according to new research led by the University of Cambridge and the University of Southampton, in collaboration with the University of Rome Tor Vergata in Italy.
Related Brain Reading:
The Brain: The Story of You
by David Eagleman (Author)
Locked in the silence and darkness of your skull, your brain fashions the rich narratives of your reality and your identity. Join renowned neuroscientist David Eagleman for a journey into the questions at the mysterious heart of our existence. What is reality? Who are “you”? How do you make decisions? Why does your brain need other people? How is technology poised to change what it means to be human? In the course of his investigations, Eagleman guides us through the world of extreme sports, criminal justice, facial expressions, genocide, brain surgery, gut feelings, robotics, and the... View Details
Switch On Your Brain: The Key to Peak Happiness, Thinking, and Health
by Dr. Caroline Leaf (Author)
Scientist and therapist helps readers understand how the power of their thoughts can help them manage stress, break unhealthy patterns, use their brains more effectively, and overcome mental, emotional, physical, and spiritual obstacles. View Details
Brain Rules (Updated and Expanded): 12 Principles for Surviving and Thriving at Work, Home, and School
by John Medina (Author)
Most of us have no idea what’s really going on inside our heads. Yet brain scientists have uncovered details every business leader, parent, and teacher should knowlike the need for physical activity to get your brain working its best.
How do we learn? What exactly do sleep and stress do to our brains? Why is multi-tasking a myth? Why is it so easy to forgetand so important to repeat new knowledge? Is it true that men and women have different brains?
In Brain Rules, Dr. John Medina, a molecular biologist, shares his lifelong interest in how the brain sciences might... View Details
The Brain's Way of Healing: Remarkable Discoveries and Recoveries from the Frontiers of Neuroplasticity
by Norman Doidge (Author)
NEW YORK TIMES BESTSELLER
The New York Times–bestselling author of The Brain That Changes Itself presents astounding advances in the treatment of brain injury and illness. Now in an updated and expanded paperback edition.
Winner of the 2015 Gold Nautilus Award in Science & Cosmology
In his groundbreaking work The Brain That Changes Itself, Norman Doidge introduced readers to neuroplasticity—the brain’s ability to change its own structure and function in response to activity and mental experience. Now his revolutionary... View Details
Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain–for Life
by David Perlmutter (Author), Kristin Loberg (Contributor)
The bestselling author of Grain Brain uncovers the powerful role of gut bacteria in determining your brain's destiny.
Debilitating brain disorders are on the rise-from children diagnosed with autism and ADHD to adults developing dementia at younger ages than ever before. But a medical revolution is underway that can solve this problem: Astonishing new research is revealing that the health of your brain is, to an extraordinary degree, dictated by the state of your microbiome - the vast population of organisms that live in your body and outnumber your own cells... View Details
Your Fantastic Elastic Brain: Stretch It, Shape It
by JoAnn Deak Ph.D. (Author), Sarah Ackerley (Illustrator)
A Mom's Choice Gold Award Winner!
What does your brain really do?
Did you know you can stretch and grown your own brain? Or that making mistakes is one of the best ways your brain learns? Just like how lifting weights helps your muscles get stronger, trying new things without giving up strengthens your brain.
This fun and engaging introduction to the anatomy and functions of the brain will empower each young reader to S-T-R-E-T-C-H and grow their Fantastic, Elastic Brain!
Other Awards for Your Fantastic,... View Details Exceptional nonfiction for children from two of the most trusted names in science education: Seymour Simon and the Smithsonian Institution. The 2017 National Book Critics Circle (NBCC) Finalist, International Bestseller, and a Kirkus Best Nonfiction Book of 2017!
The Brain: All about Our Nervous System and More!
by Seymour Simon (Author)
Admissions: Life as a Brain Surgeon
by Henry Marsh (Author)
“Marsh has retired, which means he’s taking a thorough inventory of his life. His reflections and recollections make Admissions an even more introspective memoir than his first, if such a thing is possible.” ―The New York Times
"Consistently entertaining...Honesty is abundantly apparent here--a quality as rare and commendable in elite surgeons as one suspects it is in... View Details
The Better Brain Solution: How to Start Now--at Any Age--to Reverse and Prevent Insulin Resistance of the Brain, Sharpen Cognitive Function, and Avoid Memory Loss
by Steven Masley (Author)
Diabetes ... Alzheimer's disease ... here, from the author of the best-selling 30-Day Heart Tune-Up and Smart Fat, is the first book to show how the brain can become insulin resistant through diet and lifestyle, and to make clear how and why this has been directly linked to cognitive decline and memory loss. With a detailed program developed by the author to prevent and reverse this potentially devastating condition.
Alzheimer's disease is the #1 most terrifying disease today. Despite billions of dollars of research, there are no significant cures for dementia or... View Details
Neuroscience: Exploring the Brain
by Mark F. Bear (Author), Barry W. Connors (Author), Michael A. Paradiso (Author)
Publisher’s Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product.
Acclaimed for its clear, friendly style, excellent illustrations, leading author team, and compelling theme of exploration, Neuroscience: Exploring the Brain, 4e takes a fresh, contemporary approach to the study of neuroscience, emphasizing the biological basis of behavior. The authors’ passion for the dynamic field of neuroscience is evident on every page, engaging students... View Details
Exceptional nonfiction for children from two of the most trusted names in science education: Seymour Simon and the Smithsonian Institution.Book Details:Format: PaperbackPublication Date: 5/23/2006Pages: 32Reading Level: Age 6 and Up View Details
The 2017 National Book Critics Circle (NBCC) Finalist, International Bestseller, and a Kirkus Best Nonfiction Book of 2017!