Marijuana may produce psychotic-like effects in high-risk individualsSeptember 13, 2017
New York, NY (Sept. 13, 2017) - Marijuana may bring on temporary paranoia and other psychosis-related effects in individuals at high risk of developing a psychotic disorder, finds a preliminary study from researchers at Columbia University Medical Center (CUMC).
The study was published last month in an online edition of Psychiatry Research.
Individuals who have had mild or transient psychotic symptoms (such as unusual thoughts, suspiciousness, perceptual disturbances) without using substances such as marijuana or alcohol and have a family history of psychosis or other risk factors are considered at clinical high risk for psychotic disorder. Previous studies have found an association between marijuana use and psychosis in the general population, but none have rigorously examined marijuana's effects in those at greatest risk for psychosis.
"Many adolescents and young adults who are at high risk for psychosis smoke marijuana regularly or have a cannabis use disorder," said Margaret Haney, PhD, professor of neurobiology (in Psychiatry) at CUMC and senior author of the paper. "Yet researchers haven't studied the effects of marijuana in this population in a rigorous, controlled manner."
In this double-blinded, placebo-controlled laboratory study, the researchers looked at the effects of marijuana in six high-risk young adults and six controls, all experienced and current marijuana smokers who were physically healthy. Participants smoked half of an active or placebo marijuana cigarette, had psychological and physiological assessments before and after smoking, and then repeated this procedure with the opposite (active or placebo) cigarette.
After smoking active marijuana, both groups had signs of intoxication and increases in heart rate and arousal relative to the placebo. However, only the high-risk group experienced transient increases in paranoia and anxiety, as well as disrupted sensory perception and cognitive performance, after using active marijuana. Neither group experienced these effects after using the placebo.
"Although this was a small, preliminary study, it suggests that marijuana may affect individuals at high risk for psychosis differently than other marijuana users, by briefly inducing psychotic-like experiences and impairing their cognition," said Nehal Vadhan, PhD, a psychologist and associate professor in Psychiatry and Molecular Medicine at Hofstra Northwell School of Medicine and first author of the paper. "While larger studies are needed to confirm these findings, they may aid clinicians in their guidance to individuals at risk for psychosis about marijuana's potential effects."
Jeffrey Lieberman,MD, chair of psychiatry at CUMC and and former American Psychiatric Association president, noted that this report "demonstrates the convergent risks of adolescence and expanding cannabis use for the development of psychotic disorders, as well as the opportunity for preventive strategies."
Funding for the study was provided by a Brain and Behavior Research Foundation Young Investigator Award, the National Institutes of Health (DA19239, MH086125), and CUMC Irving Scholar Awards.
The authors report no financial or other conflicts of interest.
Columbia University Medical Center provides international leadership in basic, preclinical, and clinical research; medical and health sciences education; and patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. Columbia University Medical Center is home to the largest medical research enterprise in New York City and State and one of the largest faculty medical practices in the Northeast. The campus that Columbia University Medical Center shares with its hospital partner, New York-Presbyterian, is now called the Columbia University Irving Medical Center. For more information, visit cumc.columbia.edu or columbiadoctors.org.
Columbia University Department of Psychiatry
Columbia Psychiatry is among the top ranked psychiatry departments in the nation and has contributed greatly to the understanding and treatment of brain disorders. Co-located at the New York State Psychiatric Institute on the New York-Presbyterian Hospital/Columbia University Medical Center campus in Washington Heights, the department enjoys a rich and productive collaborative relationship with physicians in various disciplines at Columbia University's College of Physicians and Surgeons. Columbia Psychiatry is home to distinguished clinicians and researchers noted for their clinical and research advances in the diagnosis and treatment of depression, suicide, schizophrenia, bipolar and anxiety disorders, eating disorders, substance use disorders, and childhood psychiatric disorders.
Columbia University Medical Center
Related Marijuana Articles:
Paper looks at diverging trajectories of cannabis and tobacco policies in the US and attempts to explain some of the reasoning behind the different paths, while discussing possible implications.
The federal government's bill C-45 to legalize marijuana in Canada will jeopardize the health of young people and Parliament should vote against it, argues the interim editor-in-chief of CMAJ in an editorial.
A new study by RTI International suggests that unexpected highs are a consequence of using new marijuana products and edibles--products that have flooded the marijuana market since legalization of recreational marijuana use.
When high school students started smoking marijuana regularly they were less likely to get good grades and want to pursue university, according to a new study from the University of Waterloo.
You wouldn't think chili peppers and marijuana have much in common.
In the first prospective study of synthetic cannabinoids or SCs -- the group of chemicals that mimic the effects of marijuana -- researchers have found that symptoms of depression, drinking alcohol, or using marijuana was linked to an increased risk of SC use one year later.
College students who consume medium-to-high levels of alcohol and marijuana have a consistently lower GPA, according to a study published March 8, 2017 in the open-access journal PLOS ONE by Shashwath Meda from Hartford Hospital/Institute of Living, USA, and colleagues.
As more states begin to legalize the use of marijuana, more young people may believe that it's safe to experiment with the drug.
Marijuana use significantly increased and its perceived harm decreased among eighth- and 10th-graders in Washington state following enactment of recreational marijuana laws, according to a UC Davis and Columbia University study.
Marijuana use increased and the drug's perceived harmfulness decreased among eighth- and 10th-graders in Washington after marijuana was legalized for recreational use by adults but there was no change among 12th-graders or among students in the three grades in Colorado after legalization for adults there, according to a new study published online by JAMA Pediatrics.
Related Marijuana Reading:
The Little Black Book of Marijuana: The Essential Guide to the World of Cannabis (3rd Edition) (Little Black Books (Peter Pauper Hardcover))
by Steve Elliott (Author)
This concise guide to cannabis delves into pot culture and history, from Herodotus to the hippies and beyond.It also covers the essentials of using, cultivating, and cooking with weed; identifying pot varieties; and understanding legal and health issues.Handy and to the point, The Little Black Book of Marijuana gives you "the dope" on pot, from possible side effects and risks to medical uses and their efficacy. Learn about cannabis history and the issues around its legalization. Includes full-color photos of marijuana varieties.... View Details
Marijuana Horticulture: The Indoor/Outdoor Medical Grower's Bible
by Jorge Cervantes (Author)
With 512 full color pages and 1120 full color photographs and illustrations, Marijuana Horticulture: The Indoor/Outdoor Medical Grower's Bible is the most complete cultivation book available. The Fifth Edition of the former Indoor Marijuana Horticulture: The Indoor Bible was originally published in 1983, when it immediately became a best seller. More than 500,000 copies of the Indoor Bible are in print in Dutch, English, French, German and Spanish.
New greenhouse and outdoor growing chapters make this a book both indoor and outdoor growers will keep... View Details
Marijuana Grower's Handbook: Your Complete Guide for Medical and Personal Marijuana Cultivation
by Ed Rosenthal (Author), Tommy Chong (Foreword)
The all new Marijuana Grower’s Handbook shows both beginners and advanced growers how to grow the biggest most resinous, potent buds! This book contains the latest knowledge, tools, and methods to grow great marijuana indoors and out. Use the most efficient technology and save time, labor, and energy. Ed Rosenthal has been teaching people how to grow marijuana for more than 30 years. Let him help you cultivate bountiful buds and lots of them. With 500 pages of full color photos and illustrations, the book delivers all the basics that a novice grower needs, as well as scientific research... View Details
Marijuana: The Unbiased Truth about the World's Most Popular Weed
by Kevin P Hill (Author)
The leading clinical expert on marijuana sifts through the myths about the drug to deliver an unbiased, comprehensive guide backed by scientific facts to give you the information you need to make informed decisions about marijuana.
Marijuana--or weed, pot, grass, MJ, Mary Jane, reefer, cannabis, or hemp among dozens of other names--has a long, colorful history dating back more than 2,000 years as the one of the most sought-after mood-altering substances in the world. Societal opinion about the drug has dramatically swayed over the years, from viewing it as a grave danger to society in... View Details
Marijuana Edibles: 40 Easy & Delicious Cannabis-Infused Desserts
by Laurie Wolf (Author), Mary Thigpen (Author)
Fun, yet practical, Marijuana Edibles features 40 baked goods, candy confections, and sweet-and-salty treats made with marijuana. It includes the two most popular extraction methods and demystifies the process of cooking with weed. Many of its wide range of tasty recipes are aimed at those with dietary restrictions ranging from vegan to gluten-free. Coverage also includes a section on quick ways to ingest (in case you don't have the time to cook up something yummy, or don't feel like doing it), as well as delicious recipes for chocolates and truffles.View Details
Cannabis Pharmacy: The Practical Guide to Medical Marijuana - Revised and Updated
by Michael Backes (Author), Andrew Weil (Foreword)
In Cannabis Pharmacy, expert Michael Backes offers evidence-based information on using cannabis to address symptoms associated with an array of ailments and conditions. He provides information on how cannabis works with the body's own endocannabinoid system, how best to prepare and administer it, and how to modify and control dosage. This newly revised edition is now completely up-to-date with the latest information on delivery and dosing of cannabis, including e-cigarette designs, additional cannabis varieties, and a new system for their classification, as well as 21 additional... View Details
The Cannabis Encyclopedia: The Definitive Guide to Cultivation & Consumption of Medical Marijuana
by Jorge Cervantes (Author), Foreword by Vicente Fox Quesada (Author), Fred Gardner (Author), Dr. John McPartland (Author), Samantha Miller (Author), Linda Meyer (Editor), Ralph Bogus (Editor), Christopher Valdés (Editor), Photographer: Mel Frank (Editor), Photographer: Left Foot (Editor), Photographer: Toni13 (Editor)
The award winning Cannabis Encyclopedia is the definitive guide to medical marijuana cultivation and consumption. It explains all the essential techniques to grow indoors, outdoors and in greenhouses. All gardening practices are well-researched and illustrated with easy step-by-step examples and instructions.
More than 2,000 beautiful color images illustrate this 596-page book. The large 8.5 x 11-inch format, three-column pages are easy to read and packed with up-to-date information that make this book essential for all cannabis gardeners and patients.
Chapters on medical cannabis... View Details
The Medical Marijuana Dispensary: Understanding, Medicating, and Cooking with Cannabis
by Laurie Wolf (Author), Mary Wolf (Author), Paul Armentano Deputy Director of NORML (Foreword)
“It’s a category that used to begin and end with the bone-dry pot brownie, served in a college dorm room. Laurie Wolf is a leader in its gourmet revolution.”
―“The Martha Stewart of Marijuana Edibles,” The New Yorker magazine
The use of medical marijuana has been a valuable resource in the treatment of various conditions. But for many, the stigma and misinformation surrounding the medical or recreational use of cannabis is a deterrent in trying it for themselves. Part reference guide, part cannabis cookbook, The Medical Marijuana... View Details HAVE YOU ALWAYS WISHED YOU COULD GROW YOUR OWN POT, BUT DIDN’T KNOW HOW? Find out how with: Growing marijuana, a Quick Start Indoor/Outdoor Grower’s Guide for Medical and Personal Marijuana Cultivation Marijuana has faced prohibition in countries throughout the world, especially the United States. It has been criminalized many times, but we are finally taking all the necessary steps toward legalization. It is legalized for medical use in more than half of the states in the U.S., with some of them allowing you to grow your own for medical use. There... View Details
Marijuana: A Short History (The Short Histories)
by John Hudak (Author)
From Reefer Madness to legal purchase at the corner store.
With long-time legal and social barriers to marijuana falling across much of the United States, the time has come for an accessible and informative look at attitudes toward the dried byproduct of Cannabis sativa. Marijuana: A Short History profiles the politics and policies concerning the five-leaf plant in the United States and around the world.
Millions of Americans have used marijuana at some point in their lives, yet it remains a substance shrouded... View Details
Marijuana: Growing Marijuana, A QuickStart Indoor And Outdoor Grower's Guide For Medical And Personal Marijuana
by Gary Keller (Author), R. Moore (Author)
HAVE YOU ALWAYS WISHED YOU COULD GROW YOUR OWN POT, BUT DIDN’T KNOW HOW?
Find out how with: Growing marijuana, a Quick Start Indoor/Outdoor Grower’s Guide for Medical and Personal Marijuana Cultivation
Marijuana has faced prohibition in countries throughout the world, especially the United States. It has been criminalized many times, but we are finally taking all the necessary steps toward legalization. It is legalized for medical use in more than half of the states in the U.S., with some of them allowing you to grow your own for medical use. There... View Details