Sig­nal­ing path­way altered in can­cer con­trols nor­mal kid­ney de­vel­op­ment

September 13, 2018

The prevalence of kidney diseases is growing rapidly due to an aging population and an increased incidence of diseases like diabetes. Moreover, congenital anomalies of the kidney are among the most frequently occurring birth defects and play crucial causative roles in the development of renal diseases.

Currently, the only treatments for these diseases are dialysis and transplantation, which are insufficient and expensive with a higher mortality rate than in most cancers.

Development of new diagnostic and therapeutic modalities for renal diseases requires detailed knowledge of the mechanisms regulating kidney development. Significant advances were made in recent research in University of Helsinki where MAPK pathway, of which aberrations are linked to many types of cancers, was identified as a key regulator of the final nephron number in a mature kidney.

MAPK pathway mediates extracellular growth factor stimuli to the cell interior. It has functions in both the cell nucleus, where it controls DNA by binding to target regions, and in the cytosol, where it regulates activities of many different proteins.

A study now published in Stem Cell Reports shows that MAPK activity is not only required for the normal proliferation and differentiation of nephron progenitors, but it also mediates crucial nephron progenitor interactions with the surrounding environment.

- Our results reveal that MAPK activity participates in modulating cellular adhesion, which is constantly required in developing systems to enable cellular motility and morphogenesis, explains the principal investigator Satu Kuure from the University of Helsinki, Finland.

MAPK activity modulators have long been actively in use for treating cancer patients. This, together with the now published results, gives hope for the development of stem cell-based regenerative therapies as novel treatments for patients suffering from renal diseases.

- Use of MAPK modulators allows efficient and precise activation as well as inactivation of the pathway. Timely utilization of this in patient-derived organoid differentiation may significantly improve the outcome, foresees Kuure.
-end-


University of Helsinki

Related Diabetes Articles from Brightsurf:

New diabetes medication reduced heart event risk in those with diabetes and kidney disease
Sotagliflozin - a type of medication known as an SGLT2 inhibitor primarily prescribed for Type 2 diabetes - reduces the risk of adverse cardiovascular events for patients with diabetes and kidney disease.

Diabetes drug boosts survival in patients with type 2 diabetes and COVID-19 pneumonia
Sitagliptin, a drug to lower blood sugar in type 2 diabetes, also improves survival in diabetic patients hospitalized with COVID-19, suggests a multicenter observational study in Italy.

Making sense of diabetes
Throughout her 38-year nursing career, Laurel Despins has progressed from a bedside nurse to a clinical nurse specialist and has worked in medical, surgical and cardiac intensive care units.

Helping teens with type 1 diabetes improve diabetes control with MyDiaText
Adolescence is a difficult period of development, made more complex for those with Type 1 diabetes mellitus (T1DM).

Diabetes-in-a-dish model uncovers new insights into the cause of type 2 diabetes
Researchers have developed a novel 'disease-in-a-dish' model to study the basic molecular factors that lead to the development of type 2 diabetes, uncovering the potential existence of major signaling defects both inside and outside of the classical insulin signaling cascade, and providing new perspectives on the mechanisms behind insulin resistance in type 2 diabetes and possibly opportunities for the development of novel therapeutics for the disease.

Tele-diabetes to manage new-onset diabetes during COVID-19 pandemic
Two new case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in an adult and an infant during the COVID-19 pandemic.

Genetic profile may predict type 2 diabetes risk among women with gestational diabetes
Women who go on to develop type 2 diabetes after having gestational, or pregnancy-related, diabetes are more likely to have particular genetic profiles, suggests an analysis by researchers at the National Institutes of Health and other institutions.

Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).

Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.

People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.

Read More: Diabetes News and Diabetes Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.