Physical activity may attenuate menopause-associated atherogenic changes

September 13, 2019

A new study on menopausal women shows that leisure-time physical activity is associated with a healthier blood lipid profile. However, results suggest that leisure-time physical activity does not seem to entirely offset the unfavorable lipid profile changes associated with the menopausal transition.

Women experience a rapid increase in cardiovascular disease (CVD) risk after the onset of menopause. This observation suggests the presence of factors in middle-aged women that accelerate the progression of CVD independent of chronological aging.

"It is well known that physical activity has health benefits, yet it is less clear to what extent physical activity can prevent the negative changes seen in blood lipid profiles during the menopausal transition," says Matthew Jergenson, MD, from the University of Minnesota Medical School, Minneapolis, Minnesota. "The present study examined menopausal women in the city of Jyväskylä, Finland, to explore the role of leisure-time physical activity on CVD risk factors."

ERMA study examines the effects of menopause

The present study is part of the Estrogenic Regulation of Muscle Apoptosis (ERMA) study, which examines the role of menopause on body composition, leisure-time physical activity and the risk of metabolic diseases.

"Based on our findings, leisure-time physical activity was associated with a healthier blood lipid profile," explains postdoctoral researcher Sira Karvinen from the Gerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Finland. "Yet advancing menopausal status predicted a less healthy lipid profile, suggesting that leisure-time physical activity does not entirely offset the unfavorable lipid profile changes associated with the menopausal transition."

More specifically, higher leisure-time physical activity was associated with lower total cholesterol, LDL, triglyceride and fasting blood glucose levels as well as higher HDL levels. Advancing menopausal status, in turn, was associated with higher total cholesterol, triglyceride and LDL levels.

"However, leisure-time physical activity may attenuate the unfavorable atherogenic changes in the serum CV risk factors of healthy middle-aged women," Jergenson and Karvinen state. "Hence one should not forget sport-related hobbies at middle age."

The present study is part of the Estrogenic Regulation of Muscle Apoptosis (ERMA) study, a population-based cohort study (n = 886) of middle-aged Caucasian women between 47 and 55 years of age in the Jyväskylä area. In addition, 193 women composed a longitudinal study population that was followed over the menopausal transition. Physical activity was assessed both by self-reported questionnaires and accelerometer monitoring. Serum lipid profiles (total cholesterol, LDL, HDL, triglycerides, fasting blood glucose) were analyzed to quantify cardiovascular risk factors.
-end-
The present study was carried out in collaboration between the universities of Jyväskylä and Minnesota and LIKES Research Center and is part of Adjunct Professor Eija Laakkonen's Academy of Finland project.

University of Jyväskylä - Jyväskylän yliopisto

Related Physical Activity Articles from Brightsurf:

Physical activity in the morning could be most beneficial against cancer
The time of day when we exercise could affect the risk of cancer due to circadian disruption, according to a new study with about 3,000 Spanish people  

Physical activity and sleep in adults with arthritis
A new study published in Arthritis Care & Research has examined patterns of 24-hour physical activity and sleep among patients with rheumatoid arthritis, lupus, and knee osteoarthritis.

Regular physical activity seems to enhance cognition in children who need it most
Researchers at the Universities of Tsukuba and Kobe re-analyzed data from three experiments that tested whether physical activity interventions lead to improved cognitive skills in children.

The benefits of physical activity for older adults
New findings published in the Scandinavian Journal of Medicine & Science in Sports reveal how physically active older adults benefit from reduced risks of early death, breast and prostate cancer, fractures, recurrent falls, functional limitations, cognitive decline, dementia, Alzheimer's disease, and depression.

Physical activity may protect against new episodes of depression
Increased levels of physical activity can significantly reduce the odds of depression, even among people who are genetically predisposed to the condition.

Is physical activity always good for the heart?
Physical activity is thought to be our greatest ally in the fight against cardiovascular disease.

Physical activity in lessons improves students' attainment
Students who take part in physical exercises like star jumps or running on the spot during school lessons do better in tests than peers who stick to sedentary learning, according to a UCL-led study.

Physical activity may attenuate menopause-associated atherogenic changes
Leisure-time physical activity is associated with a healthier blood lipid profile in menopausal women, but it doesn't seem to entirely offset the unfavorable lipid profile changes associated with the menopausal transition.

Are US adults meeting physical activity guidelines?
The proportion of US adults adhering to the 'Physical Activity Guidelines for Americans' from the US Department of Health and Human Services didn't significantly improve between 2007 and 2016 but time spent sitting increased.

Children from disadvantaged backgrounds do less vigorous physical activity
Children from disadvantaged backgrounds and certain ethnic minority backgrounds, including from Pakistani and Bangladeshi backgrounds, have lower levels of vigorous physical activity, according to researchers at the University of Cambridge.

Read More: Physical Activity News and Physical Activity Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.