Partial Liquid Breathing Improves Lung Function, Chances of Survival in Sick Preemies

September 13, 1996

BUFFALO, N.Y. -- A five-center trial of partial liquid ventilation to treat life-threatening respiratory distress syndrome in extremely premature infants has shown that the procedure is safe and effective, and improves lung function in some children who failed to respond to conventional treatment, increasing their chances of survival.

Corrine Leach, M.D., Ph.D., University at Buffalo assistant professor of pediatrics, headed the multi-center investigation of the procedure, which was developed by Bradley Fuhrman, M.D., UB professor of pediatrics. Leach and Fuhrman also are affiliated with the Children's Hospital of Buffalo.

Results of the trial are reported in the lead article in this week's issue of the New England Journal of Medicine.

Respiratory distress syndrome, the leading cause of death in premature infants, develops because the lungs of these tiny babies have yet to secrete surfactant, the substance that prevents the air sacs from collapsing. Conventional therapy for this condition -- increasing the pressure and oxygen concentration inside the lung in an effort to force more oxygen into the blood stream -- can cause permanent lung damage and result in a chronic disease called bronchopulmonary dysplasia.

Partial liquid ventilation involves introducing an oxygen-rich liquid called perflubron into the baby's lungs. The liquid allows the lungs to inflate with less pressure than air, and permits oxygen and carbon dioxide to pass through the air sacs and into the blood stream more easily and efficiently.

"The successful introduction of liquid into the lung and the ability of infants to breathe with liquid allows us to ventilate the lung at lower pressure, which causes less damage," Leach said. "If we can decrease the amount of lung injury, we can greatly improve the patient's outcome and perhaps prevent chronic lung disease."

The pilot study involved 13 infants born between 24-34 weeks of gestation. All had failed to respond to conventional therapy and were at risk of dying.

Carbon-dioxide levels improved in all patients while on PLV and lung functioning improved in 11 infants.

Seven of the 13 critically ill infants survived. Of those who died, three succumbed to their acute lung disease, and one from bronchopulmonary dysplasia. Two patients died of non-respiratory complications of prematurity.

Clinical trials using PLV to treat children and adults with severe respiratory distress syndrome are now under way and results are promising, Leach said.
-end-


University at Buffalo

Related Infants Articles from Brightsurf:

Most infants are well even when moms are infected by COVID-19
Infants born to women with COVID-19 showed few adverse outcomes, according to the first report in the country of infant outcomes through eight weeks of age.

Probiotic may help treat colic in infants
Probiotics -- or 'good bacteria' -- have been used to treat infant colic with varying success.

Deaf infants' gaze behavior more advanced than that of hearing infants
Deaf infants who have been exposed to American Sign Language are better at following an adult's gaze than their hearing peers, supporting the idea that social-cognitive development is sensitive to different kinds of life experiences.

Initiating breastfeeding in vulnerable infants
The benefits of breastfeeding for both mother and child are well-recognized, including for late preterm infants (LPI).

Young infants with fever may be more likely to develop infections
Infants with a high fever may be at increased risk for infections, according to research from Penn State College of Medicine.

Early term infants less likely to breastfeed
A new, prospective study provides evidence that 'early term' infants (those born at 37-38 weeks) are less likely than full-term infants to be breastfeed within the first hour and at one month after birth.

Infants are more likely to learn when with a peer
Researchers at the University of Connecticut and University of Washington looked at the mechanisms involved in language learning among nine-month-olds, the youngest population known to be studied in relation to on-screen learning.

Allergic reactions to foods are milder in infants
Majority of infants with food-induced anaphylaxis present with hives and vomiting, suggesting there is less concern for life-threatening response to early food introduction.

Non-dairy drinks can be dangerous for infants
A brief report published in Acta Paediatrica points to the dangers of replacing breast milk or infant formula with a non-dairy drink before one year of age.

Infants can't talk, but they know how to reason
A new study reveals that preverbal infants are able to make rational deductions, showing surprise when an outcome does not occur as expected.

Read More: Infants News and Infants Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.