Battling breast cancer

September 14, 2006

Dr. Myles Brown and colleagues (Dana Farber Cancer Institute) lend new insight into the transcriptional network that drives breast cancer cell proliferation in response to estrogen exposure. The majority of human breast cancers express estrogen receptor alpha (ERalpha), and grow and divide in response to estrogen. The authors have discovered that ERalpha binds to a novel enhancer in the cyclin D1 gene (CCND1) to promote estrogen-responsive cell proliferation. The researchers also delineate a number of other associated transcription factors that cooperate to regulate CCND1 expression and cell proliferation in breast cancer cells. Dr. Brown is hopeful that "the basic understanding of how estrogen promotes breast cancer growth revealed by our work will lead to the development of improved therapies that impact the lives of patients with the disease."
-end-


Cold Spring Harbor Laboratory

Related Estrogen Articles from Brightsurf:

Removal of synthetic estrogen from water
Synthetic estrogens from pharmaceuticals contaminate rivers and threaten the health of humans and fish.

Does estrogen influence alcohol use disorder?
A new study from researchers at the University of Illinois at Chicago shows that high estrogen levels may make alcohol more rewarding to female mice.

Estrogen's role in the sex differences of alcohol abuse
Fluctuating estrogen levels may make alcohol more rewarding to female mice, according to new research in JNeurosci.

Estrogen's opposing effects on mammary tumors in dogs
Estrogen's role in canine mammary cancer is more complex than previously understood, according to new research led by the University of Pennsylvania School of Veterinary Medicine.

Placenta transit of an environmental estrogen
The human foetus is considered to be particularly sensitive to environmental contaminants.

Estrogen improves Parkinson's disease symptoms
Brain-selective estrogen treatment improves the symptoms of Parkinson's disease in male mice, according to new research published in JNeurosci.

The sneaky way estrogen drives brain metastasis in non-estrogen-dependent breast cancers
University of Colorado Cancer Center study shows that while estrogen doesn't directly affect triple-negative breast cancer cells, it can affect surrounding brain cells in ways that promote cancer cell migration and invasiveness

New study demonstrates effectiveness and safety of vaginal estrogen
Despite its proven effectiveness in treating the genital symptoms of menopause, low-dose vaginal estrogen therapy remains underused largely because of misperceptions regarding its safety.

Hidden estrogen receptors in the breast epithelium
EPFL scientists have uncovered that next to estrogen receptor positive and negative there are cells with very low amounts of the receptor protein.

Estrogen may protect against depression after heart attack
Estrogen may protect against heart failure-related depression by preventing the production of inflammation-causing chemicals in the brain.

Read More: Estrogen News and Estrogen Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.