Nav: Home

Do titanium dioxide particles from orthopedic implants disrupt bone repair?

September 14, 2017

New Rochelle, NY, Sept. 14, 2017 -- Researchers from the Mayo Clinic have proposed that negative cellular responses to titanium-based nanoparticles released from metal implants interfere in bone formation and resorption at the site of repair, resulting in implant loosening and joint pain. Their review of recent scientific evidence and call for further research to characterize the biological, physical, and chemical interactions between titanium dioxide nanoparticles and bone-forming cells is published in BioResearch Open Access, a peer-reviewed open access journal from Mary Ann Liebert, Inc., publishers. The article is available free on theBioResearch Open Access website.

Jie Yao, Eric Lewallen, PhD, David Lewallen, MD, Andre van Wijnen, PhD, and colleagues from the Mayo Clinic, Rochester, MN and Second Affiliated Hospital of Soochow University, China, coauthored the article entitled "Local Cellular Responses to Titanium Dioxide from Orthopedic Implants The authors examined the results of recently published studies of titanium-based implants, focusing on the direct and indirect effects of titanium dioxide nanoparticles on the viability and behavior of multiple bone-related cell types. They discuss the impact of particle size, aggregation, structure, and the specific extracellular and intracellular (if taken up by the cells) effects of titanium particle exposure.

"The adverse effects of metallic orthopedic particles generated from implants are of significant clinical interest given the large number of procedures carried out each year. This article reviews our current understanding of the clinical issues and highlights areas for future research," says BioResearch Open Access Editor Jane Taylor, PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, Scotland.

Research reported in this publication was supported by the National Institutes of Health under Award Numbers R01 AR049069 and F32 AR068154. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
-end-
About the Journal

BioResearch Open Access is a peer-reviewed open access journal led by Editor-in-Chief Robert Lanza, MD, Head of Astellas Global Regenerative Medicine and Chief Scientific Officer, Astellas Institute for Regenerative Medicine (Marlborough, MA), and Editor Jane Taylor, PhD, MRC Centre for Regenerative Medicine, University of Edinburgh. The Journal provides a new rapid-publication forum for a broad range of scientific topics including molecular and cellular biology, tissue engineering and biomaterials, bioengineering, regenerative medicine, stem cells, gene therapy, systems biology, genetics, biochemistry, virology, microbiology, and neuroscience. All articles are published within 4 weeks of acceptance and are fully open access and posted on PubMed Central. All journal content is available on the BioResearch Open Access website.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many areas of science and biomedical research, including DNA and Cell Biology, Tissue Engineering, Stem Cells and Development, Human Gene Therapy, HGT Methods, and HGT Clinical Development, and AIDS Research and Human Retroviruses. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

Mary Ann Liebert, Inc./Genetic Engineering News

Related Bone Formation Articles:

Another reason to exercise: Burning bone fat -- a key to better bone health
It's a fat-burning secret anyone interested in bone health should know.
New insights on triggering muscle formation
A team of scientists led by Lorenzo Puri, M.D., Ph.D., has identified a previously unrecognized step in stem cell-mediated muscle regeneration.
Prolonged sleep disturbance can lead to lower bone formation
Insufficient sleep, a common problem that has been linked to chronic disease risk, might also be an unrecognized risk factor for bone loss.
Weight-bearing exercises promote bone formation in men
Osteoporosis affects more than 200 million people worldwide and is a serious public health concern, according to the National Osteoporosis Foundation.
New evidence on the formation of the solar system
International research involving a Monash University scientist is using new computer models and evidence from meteorites to show that a low-mass supernova triggered the formation of our solar system.
Getting to bottom of crater formation
The first results of a recent drilling expedition at Chicxulub crater -- one of the only known craters on Earth with a well-preserved 'peak ring' -- reveal how it collapsed to form a complex crater.
The rise and fall of galaxy formation
An international team of astronomers has charted the rise and fall of galaxies over 90 percent of cosmic history.
Injected mix of bone-augmenting agents causes new bone growth in mouse jaws
A Tokyo Medical and Dental University(TMDU)-centered research team combined a protein that stimulates bone formation with a peptide that promotes osteoblast differentiation, and delivered them into mouse jawbones by injection within a gelatin carrier.
Soluble corn fiber can help young women build bone, and older women preserve bone
Supplementing with soluble corn fiber at two critical times in a woman's life -- adolescence and post-menopause -- can help build and retain calcium in bone, according to new research from Purdue University.
Opioids regulate spermatozoon formation
Infertility has become a major medical and social problem worldwide and many of the cases are due to male infertility.

Related Bone Formation Reading:

Building Bones: Bone Formation and Development in Anthropology (Cambridge Studies in Biological and Evolutionary Anthropology)
by Christopher J. Percival (Editor), Joan T. Richtsmeier (Editor)

Bone is the tissue most frequently recovered archaeologically and is the material most commonly studied by biological anthropologists, who are interested in how skeletons change shape during growth and across evolutionary time. This volume brings together a range of contemporary studies of bone growth and development to highlight how cross-disciplinary research and new methods can enhance our anthropological understanding of skeletal variation. The novel use of imaging techniques from developmental biology, advanced sequencing methods from genetics, and perspectives from evolutionary... View Details


Amelogenins: Multifaceted Proteins for Dental and Bone Formation and Repair (Frontiers between Science and Clinic in Odontology)
by Michel Goldberg (Author)

This volume is the first in a series of books that bridges the gap between advances in science and clinical practice in odontology. Recent advances in biology, materials science and tissue engineering are increasingly viewed as being of enormous clinical potential. Stem cell research has opened up the possibility of reconstructing teeth from the association of epithelial and mesanchymal embryonic or adult cells, as an exciting alternative to metal implants. This book will examine the multifunctional nature of a group of proteins known as the amelogenins. Latest studies indicate that this... View Details


Junqueira's Basic Histology: Text and Atlas, Thirteenth Edition
by Anthony Mescher (Author)

The histology text the medical field turns to first -- authoritative, concise, beautifully illustrated, and completely up-to-date

More than 600 full-color illustrations

For more than three decades, Junquiera's Basic Histology has been unmatched in its ability to explain the relationship between cell and tissue structure with their function in the human body. Updated to reflect the latest research in the field and enhanced with more than 600 full-color illustrations, the thirteenh edition of Junqueira's represents the most comprehensive and... View Details


Anatomy and Injuries of the Shoulder Anatomical Chart
by Anatomical Chart Company (Author)

A detailed chart showing normal anatomy of the Shoulder as well as common injuries. Each illustration is clealy labeled and injuries are textually described.   

Anatomy and Injuries of the Shoulder illustrates the following normal anatomy:
Anterior view showing muscles, bones, liagments, nerves, veins and arterires
Anterior view  (deep Layer) of the bones, ligaments and mucsle  
Posterior view, superior  and lateral views of the bones of the shoulder
Detail of the right shoulder socket 
 
Anatomy and Injuries of the... View Details


Solgar Natural Vitamin K2 (MK-7) Vegetable Capsules, 100 Mcg (2 PACK)
by Solgar (Publisher)

Vitamin K-2, also known as menaquinone, supports normal blood clotting and activates enzymes responsible for bone formation. Trademarked variety of vitamin K called menaq7. Great way to get your daily value of this vital nutrient. Easy-to-swallow softgels. View Details


Pathophysiology of Blood Disorders, Second Edition
by Howard Franklin Bunn (Author), Jon C. Aster (Author)

The acclaimed full-color review of the underlying principles of blood diseases and disorders – based on a Harvard Medical School hematology course

A  Doody's Core Title for 2017!

LANGE Pathophysiology of Blood Disorders, Second Edition is a well-illustrated, easy-to-absorb... View Details


The Lady Who Loved Bones
by Jack Hazen (Author)

The wild west just got wilder. The widow Hannah Monroe, a beautiful blonde paleontologist from Philadelphia, ventures into the remote parts of the Montana Territory in the late spring of 1867. The members of her expedition, organized and financed by Professor Joseph Leidy of the Academy of Natural Sciences, are massacred by Cheyenne on the warpath along the Bozeman Trail. She is captured but is rescued from a horrific fate of rape and enslavement by the enigmatic Hex Hawkins, mountain man, former spy during the war, and owner of a secret gold mine. Lady Monroe, as she becomes known, must... View Details


DRY BONES DANCING: Resurrecting Your Spiritual Passion
by Tony Evans (Author)

God’s Spirit once took the prophet Ezekiel to a vast valley filled with brittle, parched-dry bones—a potent picture of widespread spiritual dryness. But by the Word of God proclaimed through Ezekiel’s mouth, those piles of bones took on sinew and flesh and skin, then were infused with life-giving, wind-driven breath from the Spirit of God. A sweeping vista of skeletons was turned instead into a force of fired-up warriors ready to do battle for the Lord. A transformation just as dramatic is what God wants to generate in our individual lives today and in the life of His church.... View Details


Pathophysiology of Blood Disorders (Lange Medical Books)
by Howard Franklin Bunn (Author), Jon C. Aster (Author)

A concise full-color review of the mechanisms of blood diseases and disorders – based on a Harvard Medical School hematology course

2015 Doody's Core Title!

4 STAR DOODY'S REVIEW!

"This is a superb book. Deceptively small, yet packs a wallop. The emphasis on principles instead of practice is welcome....The text is clear, concise, and surprisingly approachable for what could have been a very dense and dry discussion. I could not put this book down and read it entirely in one sitting. When was the last time anyone found a hematology textbook so... View Details


Craniofacial Development, Volume 115 (Current Topics in Developmental Biology)
by Yang Chai (Editor)

Craniofacial Development, the latest volume of Current Topics in Developmental Biology continues the legacy of this premier serial with quality chapters authored by leaders in the field.

This volume covers research methods in Craniofacial Development, and includes sections on such topics as microRNAs in craniofacial development and epigenetic regulation in craniofacial development.

Provides a comprehensive book on craniofacial development and tissue regenerationAuthored by leading experts in this fieldCarefully organized to cover an array of topics critical in... View Details

Best Science Podcasts 2017

We have hand picked the best science podcasts for 2017. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Simple Solutions
Sometimes, the best solutions to complex problems are simple. But simple doesn't always mean easy. This hour, TED speakers describe the innovation and hard work that goes into achieving simplicity. Guests include designer Mileha Soneji, chef Sam Kass, sleep researcher Wendy Troxel, public health advocate Myriam Sidibe, and engineer Amos Winter.
Now Playing: Science for the People

#448 Pavlov (Rebroadcast)
This week, we're learning about the life and work of a groundbreaking physiologist whose work on learning and instinct is familiar worldwide, and almost universally misunderstood. We'll spend the hour with Daniel Todes, Ph.D, Professor of History of Medicine at The Johns Hopkins University, discussing his book "Ivan Pavlov: A Russian Life in Science."