Nav: Home

Online tool informs recovery prospects for sepsis survivors

September 15, 2020

The tool, available online, is the first of its kind and was developed and validated using anonymised data from around 120,000 sepsis patients from the ICNARC national database for critical care units across England.

The new tool is particularly timely as both survivors of sepsis and COVID-19 have risks of complications or death after leaving hospital and because the winter months are associated with an increase in sepsis admissions to hospital. The free, online tool could help inform patient care pathways to prevent unplanned readmissions to hospital and excess deaths.

Sepsis is a serious complication of infection. It occurs when the body's immune system goes into overdrive in response to an infection and can lead to multiple organ failure and death. In 2017, there were an estimated 48.9 million new diagnoses of sepsis worldwide.

Previous work by this team has shown that sepsis survivors are at an increased risk of adverse events such as unplanned rehospitalisation (in 40% of sepsis survivors) and death (in 15% of sepsis survivors). The risk is at its highest in the first year after leaving hospital Currently, sepsis survivors do not receive consistent follow-up care to tackle these risks. One reason for this may be the lack of a simple tool to assess patients' risk.

The work to develop the tool was led by Dr Manu Shankar-Hari, a consultant in intensive care medicine at Guy's and St Thomas' Reader in Intensive Care Medicine at King's College London and NIHR Clinician Scientist. He said: "It is well recognised that some people who survive sepsis are at an increased risk of unplanned rehospitalisation and of death in the first year after they leave hospital.

"We provide a simple and free online tool for use. Our vision is that by providing health care professionals and sepsis survivors a simple 'score' to explicitly understand risk, it may help improve follow-up care of sepsis survivors. The score could inform how to develop clinical pathways and support sepsis survivors' choices around their ongoing care.

"Looking ahead, we hope that this online tool will help to reduce unplanned rehospitalisation and death after surviving sepsis by informing clinical trials, through better stratification of risk and evidence-based care of sepsis survivors."

The tool was developed using data from 94,748 patients. The team determined eight factors which affected risk for sepsis survivors: previous hospitalisations in the preceding year, age, socioeconomic status, pre-existing dependency (refers to how much support was required prior to hospitalisation for activities of daily living such as washing and dressing), numbers of pre-existing conditions, admission type, site of infection and admission blood haemoglobin level. Using these, they developed a statistical model that could give an overall risk score for rehospitalisation or death in the first year after leaving hospital.

The tool was then tested in a second group of 24,669 patients. The team found that the calculations were valid in this separate group.
The online tool has been reviewed and endorsed by the Intensive Care Society. This research was funded by an NIHR Clinician Scientist grant to Dr Manu Shankar-Hari and supported by ICNARC.

National Institute for Health Research

Related Sepsis Articles:

Hormone involved in obesity is a risk factor for sepsis
A group of scientists from Instituto Gulbenkian de Ciência (IGC), led by Luís Moita, discovered that a hormone that has been pointed out as a treatment for obesity reduces the resistance to infection caused by bacteria and is a risk factor for sepsis.
Antihypotensive agent disrupts the immune system in sepsis
Patients who go into shock caused by sepsis (septic shock) are treated with the antihypotensive agent norepinephrine.
Milestone for the early detection of sepsis
Researchers from Graz, Austria, are developing a ground-breaking method that uses biomarkers to detect sepsis 2 to 3 days before the first clinical symptoms appear.
Breast milk may help prevent sepsis in preemies
Researchers at Washington University School of Medicine in St. Louis and Mayo Clinic in Rochester, Minn., have found -- in newborn mice -- that a component of breast milk may help protect premature babies from developing life-threatening sepsis.
Finding a new way to fight late-stage sepsis
Researchers have developed a way to prop up a struggling immune system to enable its fight against sepsis, a deadly condition resulting from the body's extreme reaction to infection.
Study: Sepsis survivors require follow-up support
Survivors of sepsis -- a life-threatening response to an infection -- have expressed a need for advocacy and follow-up support, according to a study authored by professors at the University of Tennessee, Knoxville, and the University of Tennessee Health Science Center in Memphis, and published in Dimensions of Critical Care Nursing.
After decades of little progress, researchers may be catching up to sepsis
After decades of little or no progress, biomedical researchers are finally making some headway at detecting and treating sepsis, a deadly medical complication that sends a surge of pathogenic infection through the body and remains a major public health problem.
Study changes guidelines for sepsis management
University of Arizona Health Sciences researcher ends debate among physicians regarding sepsis management.
Improving outcomes for sepsis patients
More than 1 million sepsis survivors are discharged annually from acute care hospitals in the United States.
Genes linked to death from sepsis ID'd in mice
Bacteria in the bloodstream can trigger an overwhelming immune response that causes sepsis.
More Sepsis News and Sepsis Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Debbie Millman: Designing Our Lives
From prehistoric cave art to today's social media feeds, to design is to be human. This hour, designer Debbie Millman guides us through a world made and remade–and helps us design our own paths.
Now Playing: Science for the People

#574 State of the Heart
This week we focus on heart disease, heart failure, what blood pressure is and why it's bad when it's high. Host Rachelle Saunders talks with physician, clinical researcher, and writer Haider Warraich about his book "State of the Heart: Exploring the History, Science, and Future of Cardiac Disease" and the ails of our hearts.
Now Playing: Radiolab

Insomnia Line
Coronasomnia is a not-so-surprising side-effect of the global pandemic. More and more of us are having trouble falling asleep. We wanted to find a way to get inside that nighttime world, to see why people are awake and what they are thinking about. So what'd Radiolab decide to do?  Open up the phone lines and talk to you. We created an insomnia hotline and on this week's experimental episode, we stayed up all night, taking hundreds of calls, spilling secrets, and at long last, watching the sunrise peek through.   This episode was produced by Lulu Miller with Rachael Cusick, Tracie Hunte, Tobin Low, Sarah Qari, Molly Webster, Pat Walters, Shima Oliaee, and Jonny Moens. Want more Radiolab in your life? Sign up for our newsletter! We share our latest favorites: articles, tv shows, funny Youtube videos, chocolate chip cookie recipes, and more. Support Radiolab by becoming a member today at