Nav: Home

UNC to break new ground in health innovation by sharing work with no strings attached

September 16, 2015

The University of North Carolina at Chapel Hill is the newest member of a pioneering international partnership that aims to completely map the single most successful targets for cancer drugs known to date and will share their work with no fees or restrictions on intellectual property. The unrestricted use of this map could lead to breakthrough medicines not only in the realm of cancer, but also for rheumatoid arthritis and a host of neurodegenerative disorders, including Parkinson's and Alzheimer's.

The partnership is known as the Structural Genomics Consortium, which began 11 years ago and includes Oxford University, the University of Toronto and the State University of Campinas in São Paulo, Brazil. UNC-Chapel Hill is the consortium's newest member and has launched the SGC-UNC on campus, thanks to startup funding from the UNC Eshelman Institute for Innovation, which was created by Fred Eshelman's gift to the pharmacy school in 2014.

"Because of Fred Eshelman's historic $100 million gift, we have been able to create the first SGC hub in the U.S.," said Chancellor Carol L. Folt. "SGC-UNC is going to help identify the best new targets for discovering breakthrough medicines, and we have Dr. Eshelman and an incredibly talented group of faculty, staff and students to thank for this remarkable effort."

UNC-Chapel Hill will focus on developing chemical tools that allow researchers to home in on the function of a family of proteins called kinases, enzymes that set in motion the machinery for cell growth and survival. They will then use these tools to create a functional map of this family, such that similar kinases would be grouped together. The map will help pharmaceutical companies, industry and academia narrow down on kinases they want to target for drug development depending on the disease they want to treat. Without the map, it is unclear which kinases are potential drug targets for any one disease.

"It's like exploring and opening up the American West," said Tim Willson, chief scientist of the Structural Genomics Consortium at UNC-Chapel Hill. "Everyone suspected there was something interesting out there, but until somebody went out there and made a map, people just didn't know where to build the railroads, or a new settlement. The pioneers had to go explore for the good of everyone and bring that knowledge back to share with everyone."

Although kinases have been one of the most productive areas of drug development, they are largely unexplored. Out of a family of approximately 500 proteins, only about 50 have been studied in depth, which has led to the creation of 26 drugs, 25 of which work to fight cancer - an overwhelming success rate for drug discovery. But despite their high-stakes therapeutic potential, more than 80 percent of kinases remain untapped due to the cost, risk and complexity of creating the chemical tools that yield such a map.

UNC has already seen success leveraging the SGC's work with protein kinases. In 2009, researchers at the UNC Lineberger Comprehensive Cancer Center identified a kinase that plays a role in various forms of cancer. At that time, the SGC, which did not include UNC-Chapel Hill, had already made the 3D structure of the kinase available to the public. Scientists then used the structure of the kinase to rapidly design and synthesize new compounds that shut down activity in human cancer cells.

Their work resulted in a spinoff company, Meryx, which was created in 2013 to develop new therapeutics based on the kinase inhibitors created at UNC-Chapel Hill.

"The UNC Eshelman School of Pharmacy knows firsthand the value of the work done by the SGC, and we are extremely proud to become a part of it," said Robert Blouin, dean of the school. "We are now at the center of a global network of activity that will generate many opportunities for drug discovery with protein kinases as targets for breakthrough medicines."

The new unit is made up of former employees of GlaxoSmithKline's Research Triangle Park location. GSK, one of the original funders of the SGC, is contributing the rights to use and distribute a library of chemicals developed and characterized by the company.

"The University of North Carolina at Chapel Hill is an outstanding institution, and their involvement in the SGC clearly signals their intent to speed the creation of new medicines for patients," said Aled Edwards, director and CEO of the Structural Genomics Consortium. "We're delighted to welcome UNC as our first site in the U.S."
-end-


University of North Carolina at Chapel Hill

Related Cancer Articles:

Radiotherapy for invasive breast cancer increases the risk of second primary lung cancer
East Asian female breast cancer patients receiving radiotherapy have a higher risk of developing second primary lung cancer.
Cancer genomics continued: Triple negative breast cancer and cancer immunotherapy
Continuing PLOS Medicine's special issue on cancer genomics, Christos Hatzis of Yale University, New Haven, Conn., USA and colleagues describe a new subtype of triple negative breast cancer that may be more amenable to treatment than other cases of this difficult-to-treat disease.
Metabolite that promotes cancer cell transformation and colorectal cancer spread identified
Osaka University researchers revealed that the metabolite D-2-hydroxyglurate (D-2HG) promotes epithelial-mesenchymal transition of colorectal cancer cells, leading them to develop features of lower adherence to neighboring cells, increased invasiveness, and greater likelihood of metastatic spread.
UH Cancer Center researcher finds new driver of an aggressive form of brain cancer
University of Hawai'i Cancer Center researchers have identified an essential driver of tumor cell invasion in glioblastoma, the most aggressive form of brain cancer that can occur at any age.
UH Cancer Center researchers develop algorithm to find precise cancer treatments
University of Hawai'i Cancer Center researchers developed a computational algorithm to analyze 'Big Data' obtained from tumor samples to better understand and treat cancer.
More Cancer News and Cancer Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Teaching For Better Humans
More than test scores or good grades — what do kids need to prepare them for the future? This hour, guest host Manoush Zomorodi and TED speakers explore how to help children grow into better humans, in and out of the classroom. Guests include educators Olympia Della Flora and Liz Kleinrock, psychologist Thomas Curran, and writer Jacqueline Woodson.
Now Playing: Science for the People

#535 Superior
Apologies for the delay getting this week's episode out! A technical glitch slowed us down, but all is once again well. This week, we look at the often troubling intertwining of science and race: its long history, its ability to persist even during periods of disrepute, and the current forms it takes as it resurfaces, leveraging the internet and nationalism to buoy itself. We speak with Angela Saini, independent journalist and author of the new book "Superior: The Return of Race Science", about where race science went and how it's coming back.