Reducing colorectal cancer disparities among African american men

September 16, 2020

Out of any other racial group, African American men have the lowest five-year survival rate for colorectal cancer (CRC). A major factor contributing to this dire situation is low adherence to recommended early detection screening, like colonoscopy and home-based stool testing kits. Yet, published research on effective strategies to increase screening for this group specifically are minimal. These findings were published today in a special health inequities and disparities issue of the journal PLOS ONE.

For this study, the researchers set out to understand the state of research on interventions to increase CRC screening uptake in African American men. The researchers conducted a systematic review and meta-analysis. They reviewed 41 studies published between 1998 and 2020 that examined adherence to CRC early detection methods and screening recommendations. Of these, only two studies focused exclusively on African American men. While many of the studies provide valuable insights, the researchers found the existing body of work lacks the detail needed to inform effective screening recommendations for reducing CRC incidence and deaths in African American men.

Charles R. Rogers, PhD, MPH, MS, MCHES, led the study. Rogers is a cancer investigator at Huntsman Cancer Institute and assistant professor of public health at the University of Utah, where he leads the Men's Health Inequities research lab. This group brings together researchers, advocacy organizations, clinicians, and health professionals from a variety of disciplines. They work together to improve the health and well-being of medically underserved populations through community engagement, research, and education. The research group is currently assessing the influence of numerous factors on CRC screening uptake - for example, poor patient-provider communication, masculinity barriers to medical care, health problem minimization, and medical mistrust. Rogers' team also evaluates social determinants of health in men, including lack of insurance, racism, and limited social support. His group has a longstanding interest in CRC prevention and awareness among African American men, including a 5-year study called #CuttingCRC, which aims to develop a barbershop-based intervention on masculinity barriers to medical care, psychosocial factors, and CRC screening uptake among African American men in Utah, Ohio, and Minnesota.

Rogers and his team view their PLOS ONE study as a call to action for researchers to advance understanding of factors that could improve screening completion among African American men. Limitations of existing interventional research on this issue identified by the team included lack of race and gender segmentation. More geographic representation is needed in these studies as the majority of research available is concentrated on people living in the northeast and southern parts of the United States. Also, many of the studies employed interventions among participants with regular access to health care at a major medical center - thus excluding significant representation of the African American male health care experience.

The researchers recommend more studies that focus exclusively on African American men. "To reach the goal of reducing CRC-related injustices among African American men, future health promotion and prevention interventions must explicitly focus on recruiting men belonging to this population," says Rogers. The group also advises that researchers prioritize conducting interventions in nontraditional health care settings, like churches or community centers. "It's key to meet people where they live, work, play, and worship," says Rogers.

In light of the unexpected death of Black Panther star Chadwick Boseman from CRC at age 43, Rogers and his team also emphasize the critical need for more research in African Americans younger than age 45, due to more young adults both getting the preventable disease and dying from it. Of a predicted growth of 90-124% among Americans aged 20-34 and 28-46% among those aged 35-49 by 2030, the highest growth of early-onset CRC incidence and death is predicted to occur in African American men, according to a study published in JAMA Surgery. "African American men continue to suffer the most from CRC incidence and mortality across all racial groups and genders. Advancing CRC prevention and early detection-focused research among African American men will provide critical insights - perhaps including why we need to adjust current screening recommendations - and will undoubtedly save lives," Rogers added.
The study was supported by the National Cancer Institute including P30 CA01420114 and K01 CA234319, as well as 5 For the Fight and Huntsman Cancer Foundation. Study senior author, Margaret Foster, MS, MSLIS, professor and systematic review coordinator at Texas A&M University's Medical Sciences Library, provided critical expertise for the study.

Huntsman Cancer Institute

Related Colorectal Cancer Articles from Brightsurf:

Colorectal cancer treatment: the winning combinations
Chemotherapy has distressing side effects for patients and increases the risk of developing resistance to the treatment.

A new model to predict survival in colorectal cancer
This signature could be useful in clinical practice, especially for colorectal cancer diagnosis and therapy.

Roadmap to reducing colorectal cancer deaths
The American Gastroenterological Association has outlined a strategy to increase the number of people screened via tests that are more convenient, accurate and less expensive and tailored to people's individual cancer risks.

Study provides new insight on colorectal cancer growth
A new study by researchers at the University of Kentucky identifies a novel function of the enzyme spermine synthase to facilitate colorectal cancer growth.

Researchers ID target for colorectal cancer immunotherapy
Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have identified a target for colorectal cancer immunotherapy.

Colorectal cancer partner-in-crime identified
A protein that helps colorectal cancer cells spread to other parts of the body could be an effective treatment target.

Cancer cell reversion may offer a new approach to colorectal cancer treatment
A novel approach to reverse the progression of healthy cells to malignant ones may offer a more effective way to eradicate colorectal cancer cells with far fewer side effects, according to a KAIST research team based in South Korea.

A novel pathway to target colorectal cancer
Survival rates for patients with late-stage colorectal cancer are dismal, and new therapeutic strategies are needed to improve outcomes.

Colorectal cancer rates in Canada
The incidence of colorectal cancer among younger adults increased in recent years in this analysis of data from Canadian national cancer registries that included about 688,000 new colorectal cancers diagnosed over more than 40 years.

Cancer drugs promote stem cell properties of colorectal cancer
Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Mannheim University Medical Center have now discovered that a certain group of cancer drugs (MEK Inhibitors) activates the cancer-promoting Wnt signalling pathway in colorectal cancer cells.

Read More: Colorectal Cancer News and Colorectal Cancer Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to