Other highlights in the September 18 issue of JNCI

September 17, 2002

Smoking Associated with Increased Risk of Cervical Cancer Among Human Papillomavirus-Infected Women

Current and past smoking may increase the risk of cervical cancer among women who have been infected with the human papillomavirus (HPV), according to a study in the September 18 issue of the Journal of the National Cancer Institute.

Philip E. Castle, Ph.D., of the National Cancer Institute, and his colleagues looked at the association between various risk factors and cervical cancer among 1,812 women who had tested positive for oncogenic HPV DNA. Oral contraceptive use and history of live births were not associated with the risk of cervical cancer or its precursor, cervical intraepithelial neoplasia grade 3 (CIN3). However, former and current smokers appeared to have an increased risk of cervical cancer and CIN3 compared with women who never smoked.

The authors say that future studies should examine whether biomarkers associated with smoking, such as DNA damage, are present in cervical tissue and whether such biomarkers can be detected before the development of CIN3 or cervical cancer.

Majority of Ovarian Tumors With BRCA2 Mutations Also Have BRCA1 Mutations

Mutations in the BRCA1 and BRCA2 tumor suppressor genes have been shown to play a role in hereditary ovarian cancer. To explore the interactions of mutations in these genes in ovarian cancer, Jeffrey L. Hilton, M.D., and Richard E. Buller, M.D., Ph.D., of the University of Iowa Hospitals and Clinics, and their colleagues looked for BRCA2 mutations in ovarian tumors previously screened for BRCA1 mutations. They found that multiple genetic mechanisms are responsible for the inactivation of BRCA2 in these tumors and that a majority of the tumors with BRCA2 dysfunciton also had BRCA1 dysfunction. The authors conclude that "some degree of BRCA1 and/or BRCA2 dysfunction may be of nearly universal importance for the process of ovarian carcinogenesis." The findings appear in the September 18 issue of the Journal of the National Cancer Institute.

Malignant Urothelial Cells May be Susceptible to Apoptosis by CD40 Ligation

In epithelial cells, binding of the cell-surface receptor CD40 to its ligand, CD40L, can cause different effects, including apoptosis (cell death). Urszula Bugajska, Ph.D. and Ludwik Trejdosiewicz, Ph.D., of the Cancer Research U.K. Clinical Centre, St. James's University Hospital in Leeds, and their colleagues examined the effects of CD40 ligation on the survival of normal and malignant human urothelial cells that express CD40. They found that the apoptotic responses of the cells to CD40 ligation depended on how CD40L was presented to the cells, suggesting that susceptibility to CD40 ligation-induced apoptosis may be a useful therapeutic approach for eliminating malignant urothelial cells. They add that the loss of CD40 expression by urothelial cells may be important in the development and progression of bladder cancer. The findings appear in the September 18 issue of the Journal of the National Cancer Institute.
Attribution to the Journal of the National Cancer Institute is requested in all news coverage.

Journal of the National Cancer Institute

Related Smoking Articles from Brightsurf:

Smoking rates falling in adults, but stroke survivors' smoking rates remain steady
While the rate of Americans who smoke tobacco has fallen steadily over the last two decades, the rate of stroke survivors who smoke has not changed significantly.

What is your risk from smoking? Your network knows!
A new study from researchers at Penn's Annenberg School for Communication found that most people, smokers and non-smokers alike, were nowhere near accurate in their answers to questions about smoking's health effects.

Want to quit smoking? Partner up
Kicking the habit works best in pairs. That's the main message of a study presented today at EuroPrevent 2019, a scientific congress of the European Society of Cardiology (ESC).

Smoking and mortality in Asia
In this analysis of data from 20 studies conducted in China, Japan, South Korea, Singapore, Taiwan and India with more than 1 million participants, deaths associated with smoking continued to increase among men in Asia grouped by the years in which they were born.

Predictors of successfully quitting smoking among smokers registered at the quit smoking clinic at a public hospital in northeastern Malaysia
In the current issue of Family Medicine and Community Health, Nur Izzati Mohammad et al. consider how cigarette smoking is one of the risk factors leading to noncommunicable diseases such as cardiovascular and respiratory system diseases and cancer.

Restaurant and bar smoking bans do reduce smoking, especially among the highly educated
Smoking risk drops significantly in college graduates when they live near areas that have completely banned smoking in bars and restaurants, according to a new study in the American Journal of Epidemiology.

How the UK smoking ban increased wellbeing
Married women with children reported the largest increase in well-being following the smoking bans in the UK in 2006 and 2007 but there was no comparable increase for married men with children.

Smoking study personalizes treatment
A simple blood test is allowing Vanderbilt University Medical Center (VUMC) researchers to determine which patients should be prescribed varenicline (Chantix) to stop smoking and which patients could do just as well, and avoid side effects, by using a nicotine patch.

A biophysical smoking gun
While much about Alzheimer's disease remains a mystery, scientists do know that part of the disease's progression involves a normal protein called tau, aggregating to form ropelike inclusions within brain cells that eventually strangle the neurons.

A case where smoking helped
A mutation in the hemoglobin of a young woman in Germany was found to cause her mild anemia.

Read More: Smoking News and Smoking Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.