Fructose and glucose in high fructose corn syrup deliver a one-two punch to health

September 17, 2020

Consuming high fructose corn syrup appears to be as bad for your health as consuming sugar in the form of fructose alone, according to a
When it comes to health risks, sugar in the form of fructose is clearly the bad guy. This is because a majority of fructose consumed ends up in the liver. When there is too much fructose, the liver produces uric acid and fat in the form of triglycerides, which increase the risk of fatty liver, heart disease and gout. But lead investigator Kimber Stanhope, a researcher with the UC Davis School of Veterinary Medicine, says the new data shows that we shouldn't let glucose off the hook.

"It turns out that the combination of fructose and glucose found in high fructose corn syrup appears to be worse than fructose alone for some heart disease risk factors," said Stanhope. "When we planned this study, we didn't expect to find this."

Research has shown that fructose compared with glucose increases risk factors for heart disease and diabetes. This led to an assumption that the glucose in the high fructose corn syrup is benign. The new study, published in Metabolism Journal, tested this assumption by examining differences in health risk factors based on sugar type. Participants consumed beverages containing fructose, glucose, high fructose corn syrup, or an aspartame control, and researchers analyzed their blood for known risk factors for heart disease and diabetes.

The researchers expected risk factors would be highest for fructose and lowest for glucose, with high fructose corn syrup somewhere in between. This is exactly what they saw for some of the risk factors. However, for others, including the risk factors many scientists believe are the most predictive for heart disease, the increases were highest for high fructose corn syrup due to an interaction of fructose and glucose.

CONSUMER CHOICES AND DIETARY GUIDELINES

The results of the current study suggest that dietary guidelines and consumer choices should not be based on the assumption that all adverse effects from dietary sugars are due to fructose content.

"Our study shows that nutrition is more than looking at individual food components," said first author Bettina Hieronimus with the Department of Child Nutrition at the Max-Rubner Institut in Karlsruhe, Germany. "To understand the way our food affects our bodies, we need to study diets as a whole."
-end-
Other authors include Valentina Medici, Nancy Keim, Peter Havel and Andrew Bremer with UC Davis. Funding support comes from the National Institutes of Health/National Heart, Lung and Blood Institute, the National Center for Research Resources, the German Research Foundation, the National Institute of Child Health and Human Development, the National Institute of Aging, United States Department of Agriculture-Agricultural Research Service and the UC Office of the President.

University of California - Davis

Related Fructose Articles from Brightsurf:

High fructose intake may drive aggressive behaviors, ADHD, bipolar
New research suggests that conditions such as attention deficit hyperactivity syndrome (ADHD), bipolar disorder, and even aggressive behaviors may be linked with sugar intake, and that it may have an evolutionary basis.

Study reveals dietary fructose heightens inflammatory bowel disease
Diet remains an important part of disease prevention and management, and a new study suggests that consumption of fructose may worsen intestinal inflammation common to inflammatory bowel diseases (IBD).

Fructose made in the brain could be a mechanism driving Alzheimer's disease
New research released from the University of Colorado Anschutz Medical Campus proposes that Alzheimer's disease may be driven by the overactivation of fructose made in the brain.

Fructose and glucose in high fructose corn syrup deliver a one-two punch to health
Consuming high fructose corn syrup appears to be as bad for your health as consuming sugar in the form of fructose alone, according to a new study from researchers at the University of California, Davis.

Excessive fructose consumption may cause a leaky gut, leading to fatty liver disease
Researchers at University of California San Diego School of Medicine report that fructose only adversely affects the liver after it reaches the intestines, where the sugar disrupts the epithelial barrier protecting internal organs from bacterial toxins in the gut

High fructose diet in pregnancy impacts metabolism of offspring, study finds
An increased level of fructose intake during pregnancy can cause significant changes in maternal metabolic function and milk composition and alter the metabolism of their offspring, researchers from the University of Otago, Wellington, have found.

Examining association of major food sources of fructose-containing sugars with metabolic syndrome
This study combined the results of 13 studies with nearly 50,000 participants to look at the association of major food sources of fructose-containing sugars, such as sucrose and high-fructose corn syrup, with the risk of metabolic syndrome.

The gut shields the liver from fructose-induced damage
After one consumes food or a beverage containing fructose, the gastrointestinal system, or gut, helps to shield the liver from damage by breaking down the sugar before it reaches the liver, according to a new multi-center study.

St. Michael's Hospital study examines the relationship between sugars and heart health
There's an assumption that sugars are all bad, but a study led by researchers at St.

High-fructose and high-fat diet damages liver mitochondria, study finds
High levels of fructose in the diet inhibit the liver's ability to properly metabolize fat.

Read More: Fructose News and Fructose Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.