Kidney disease increases risk of sudden cardiac death for ICD patients

September 18, 2006

End-stage kidney disease significantly increases the risk of life-threatening heart rhythm abnormalities in patients with implantable cardioverter defibrillators (ICDs), according to a study published in the October 2006 edition of Heart Rhythm. However, compared to ICD patients without kidney disease, patients with end-stage renal disease (ESRD) survived less than half as many years (3.2 years vs. 7.4 years, respectively) despite being implanted with a cardiac device.

"The study calls into question the survival benefit of ICDs in patients with this degree of kidney disease who meet current implant indications," said Dr. Rod Passman, M.D., M.S.C.E., a cardiac electrophysiologist and epidemiologist at Northwestern University School of Medicine and senior author of the study. "Continued research is needed to determine what can be done to prevent sudden death due to abnormal heart rhythms in patients with ESRD and to determine which ESRD patients can benefit from ICD therapy."

The study was conducted at Northwestern Memorial Hospital and involved 585 patients with and without ESRD prior to ICD implantation and was the first to identify kidney disease as a risk factor for appropriate ICD therapy. Therapy occurs when the device delivers a shock to terminate ventricular fibrillation or ventricular tachycardia, rhythms that may be fatal if left untreated.

More than half a million people have ESRD, which occurs when the kidneys fail to excrete harmful wastes and, as a result, causes the body to retain fluid, potassium, and other toxins. Sudden cardiac death is often the result of rapid and chaotic heart rhythms in the bottom chambers of the heart and is the most frequent cause of death in people with ESRD, though the exact cause is not fully understood.
Editor's Note: To schedule an interview with Dr. Passman or receive a copy of the article, please contact Rachael Lille Moore at 202-464-3476 or

About the Heart Rhythm Society

The Heart Rhythm Society is the international leader in science, education and advocacy for cardiac arrhythmia professionals and patients, and the primary information resource on heart rhythm disorders. Its mission is to improve the care of patients by promoting research, education and optimal health care policies and standards. Incorporated in 1979 and based in Washington, DC, it has a membership of over 4,500 heart rhythm professionals in over 74 countries around the world.

About Heart Rhythm

Heart Rhythm provides rapid publication of the most important science developments in the field of arrhythmias and cardiovascular electrophysiology. As the Official Journal of the Heart Rhythm Society, Heart Rhythm publishes both basic and clinical subject matter of scientific excellence devoted to the electrophysiology (EP) of the heart and blood vessels, as well as therapy. The journal is the only EP publication serving the entire electrophysiology community from basic to clinical academic researchers, private practitioners, technicians, industry and trainees. Heart Rhythm received a debut Impact Factor of 2.6 and was ranked 21st out of 72 cardiovascular medicine journals by the Institute for Scientific Information. Additionally, the journal ranks fifth in the Immediacy Index among cardiology publications. It is also the official publication of the Cardiac Electrophysiology Society.

The Reis Group

Related Kidney Disease Articles from Brightsurf:

Waistline matters in kidney disease
Does fat matter in kidney disease? The investigators found that all measures of higher abdominal fat content (including visceral fat, liver fat, or subcutaneous fat) and slower walk times were associated with increased levels of cardiometabolic risk factors in adults with non-dialysis dependent kidney disease.

Reducing urinary protein for patients with rare kidney disease slows kidney decline
New findings show that reducing the amount of protein in the urine of patients with focal segmental glomerulosclerosis can significantly slow declines in kidney function and extend time before patients' kidneys fail.

Antioxidant agent may prevent chronic kidney disease and Parkinson's disease
Researchers from Osaka University developed a novel dietary silicon-based antioxidant agent with renoprotective and neuroprotective effects.

Acute kidney injury and end stage kidney disease in severe COVID-19
Many COVID-19 patients experience hematuria, proteinuria and elevated serum creatinine concentration early in the course of the disease.

Genes tell a story about diabetic kidney disease
Studying Finnish genes leads to unique revelations about the development of a serious complication of diabetes, and informs an ongoing genomic study of a Singaporean cohort as part of Singapore's Diabetes Study in Nephropathy and other Microvascular Complications (DYNAMO).

New study provides insight into chronic kidney disease
Researchers have further analyzed a known signaling pathway they believe brings them one step closer to understanding the complex physiology of patients with chronic kidney disease (CKD), which might provide a path to new treatment options.

Predicting risk of chronic kidney disease
Data from about 5 million people (with and without diabetes) in 28 countries were used to develop equations to help identify people at increased five-year risk of chronic kidney disease, defined as reduced estimated glomerular filtration rate (eGFR).

A healthy diet may help prevent kidney disease
In an analysis of published studies, a healthy dietary pattern was associated with a 30% lower incidence of chronic kidney disease.

Is kidney failure a man's disease?
A new analysis of the ERA-EDTA Registry [1] reveals a striking gender difference in the incidence and prevalence of end-stage renal disease.

Chronic kidney disease: Everyone's concern
850 million people worldwide are affected by kidney disease. This worrying figure was published last June.

Read More: Kidney Disease News and Kidney Disease Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to