'Treatment disconnect' in kidney cancer: Rising mortality despite more small tumors, more surgery

September 19, 2006

The rising incidence of kidney cancer may be due to an increase in the number of small, treatable kidney tumors, according to a study in the September 20 issue of the Journal of the National Cancer Institute.

The incidence of a type of kidney cancer called renal cell carcinoma has been increasing over the past two decades. Despite the increased rates of surgery that have accompanied this trend, death rates have not decreased.

Brent K. Hollenbeck, M.D., of the University of Michigan in Ann Arbor, and colleagues identified 34,503 cases of kidney cancer using data from nine Surveillance, Epidemiology, and End Results registries collected between 1983 and 2002.

They observed that cancer incidence rose from 7.1 cases per 100,000 to 10.8 cases per 100,000. Tumors 4 cm or smaller, called small renal masses, accounted for the majority of this increase. Surgeries rose at the same rate, but mortality rates also increased. The authors suggest that surgery may not be an appropriate treatment for those tumors, which are often slow-growing and discovered in patients without symptoms related to kidney problems.

"These data do not encourage an abrupt departure from the current treatment paradigm for kidney cancer; rather, they prompt reflection on our clinical practice and suggest the need for investigation to address the observed 'treatment disconnect' that we are treating more and more small renal masses but are not impacting mortality," they write.
Brent Hollenbeck, bhollen@umich.edu

Hollingsworth JM, Miller DC, Daignault S, Hollenbeck BK. Rising incidence of small renal masses: A need to reassess treatment effect. J Natl Cancer Inst 2006; 98: 1331-1334.

The Journal of the National Cancer Institute is published by Oxford University Press and is not affiliated with the National Cancer Institute. Attribution to the Journal of the National Cancer Institute is requested in all news coverage. Visit the Journal online at http://jncicancerspectrum.oxfordjournals.org/.

Journal of the National Cancer Institute

Related Kidney Cancer Articles from Brightsurf:

Reducing urinary protein for patients with rare kidney disease slows kidney decline
New findings show that reducing the amount of protein in the urine of patients with focal segmental glomerulosclerosis can significantly slow declines in kidney function and extend time before patients' kidneys fail.

Acute kidney injury and end stage kidney disease in severe COVID-19
Many COVID-19 patients experience hematuria, proteinuria and elevated serum creatinine concentration early in the course of the disease.

Cutting off kidney cancer at its roots
Scientists at the MDC have discovered stem cells responsible for the most common form of kidney cancer.

Finding familiar pathways in kidney cancer
The famous cancer gene p53, which was thought to be less relevant in kidney cancer, may play a larger role than previously appreciated, suggesting new potential for treatment.

Root of childhood kidney cancer discovered
A fundamental change in our understanding of the childhood kidney cancer Wilms' tumor is on the horizon, after the discovery of its earliest genetic root by scientists at the Wellcome Sanger Institute and their collaborators.

Kidney-resident macrophages -- a role for healing during acute kidney injury?
Researchers have found that, during acute kidney injury in a mouse model, the kidney-resident macrophages are reprogrammed to a developmental state, resembling these same cells when they are found in newborn mice.

Antibodies to a retina protein to be used as a kidney cancer marker
Sechenov University together with their German colleagues suggest a new highly sensitive, quick, and pain-free method for diagnosing kidney cancer.

Revealed: 35 kidney genes linked to chronic kidney disease risk
An international study lead by University of Manchester scientists has discovered the identity of genes that predispose people to chronic kidney disease.

High-dose, high-precision radiation therapy safe, effective for solitary kidney cancer patients with only one kidney
Treatment of renal cell carcinoma with stereotactic radiation therapy is as safe and effective for patients with one kidney as it is for those who have two, according to an analysis of the largest-ever, international dataset of solitary kidney patients to receive this emerging treatment.

Kidney cancer's developmental source revealed
In the first experiment of its kind, scientists have revealed the precise identity of cancer cells of the most common childhood and adult kidney cancers.

Read More: Kidney Cancer News and Kidney Cancer Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.