New generation antidepressants increase risk of gastrointestinal bleeds

September 20, 2001

(Inhibition of serotonin re-uptake by antidepressants and upper gastrointestinal bleeding in elderly patients: retrospective cohort study) BMJ Volume 323 pp 655-8

Canadian researchers monitored hospital admissions for gastrointestinal bleeding among almost 314,000 people, aged 65 and above, who had been prescribed antidepressants between 1992 and 1998. Antidepressant drugs were grouped according to what extent they inhibited serotonin re-uptake.

There were 974 gastrointestinal bleeds during the study. The higher the inhibition of serotonin re-uptake, the higher was the risk of a bleed. This was especially true of older patients in whom the risk increased by over 10 per cent for each more powerful grade of inhibitor drug, and those who had already had a bleed, in whom the risk increased by almost 10 per cent.

For patients in their 80s, bleeding rates increased from 10.6 per 1000 person years for drugs with the lowest inhibition to 14.7 with the highest. This equals an additional bleed for every 244 patients treated with the highest inhibiting drugs for a year. The data also showed that the numbers of 80 year olds prescribed SSRIs rose from 892 in 1192 to 11,179 in 1997.

Among patients who had had peptic ulcers, bleeding rates increased from over 28 to over 40 per 1000 person years. This equates to an additional bleed for every 85 patients treated with the highest inhibiting drugs for a year.

The authors conclude that the extent to which antidepressants inhibit serotonin re-uptake should be considered before prescribing these drugs to very elderly patients or those who have had a bleed before.
-end-


BMJ

Related Antidepressants Articles from Brightsurf:

Measuring brainwaves while sleeping can tell if you should switch antidepressants
Scientists have discovered that measuring brainwaves produced during REM sleep can predict whether a patient will respond to treatment from depression.

Antibodies: the body's own antidepressants
Antibodies can be a blessing or a curse to the brain -- it all depends on their concentration.

Are some antidepressants less risky for pregnant women?
About one in ten women in Qu├ębec will suffer from depression during pregnancy.

The effect of taking antidepressants during pregnancy
Exposure to antidepressants during pregnancy and the first weeks of life can alter sensory processing well into adulthood, according to research in mice recently published in eNeuro.

Significantly fewer pregnant women take antidepressants
A pregnancy is not always a happy event and as many as 10-15% of pregnant women in Denmark have depressive symptoms.

Antidepressants reduce deaths by more than a third in patients with diabetes
Antidepressants reduce deaths by more than a third in patients with diabetes and depression, according to a study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

Antidepressants can reduce the empathic empathy
Depression is a disorder that often comes along with strong impairments of social functioning.

Possible link between autism and antidepressants use during pregnancy
An international team led by Duke-NUS Medical School has found a potential link between autistic-like behaviour in adult mice and exposure to a common antidepressant in the womb.

When neurons are out of shape, antidepressants may not work
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed medication for major depressive disorder (MDD), yet scientists still do not understand why the treatment does not work in nearly thirty percent of patients with MDD.

Next-generation metabolomics may facilitate the discovery of new antidepressants
Antidepressants have become one of the most commonly prescribed drugs.

Read More: Antidepressants News and Antidepressants Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.