Immediate breast reconstruction after mastectomy does not delay chemotherapy

September 20, 2004

EMBARGOED FOR RELEASE UNTIL 3 P.M. (CT), MONDAY, SEPTEMBER 20, 2004 CHICAGO - Although there is an increased risk of wound complications in patients who underwent breast reconstruction directly after mastectomy, the procedure did not delay the initiation of postsurgical chemotherapy, according to an article in the September issue of The Archives of Surgery, one of the JAMA/Archives journals.

According to the article, "breast cancer is the most common cancer diagnosed in women in the United States today with an expected incidence of more than 200,000 women in 2003." Breast reconstruction has been shown to reduce the negative effects on self-image and psychosocial well being in women after mastectomy (removal of the breast), the article states. However, it is unknown whether wound complications following mastectomy and breast reconstruction have any effect on the initiation of chemotherapy after surgery.

Melinda M. Mortenson, M.D., of the University of California, Davis Medical Center, Sacramento, and colleagues reviewed the medical records of 128 women to determine whether the risk of wound complications was higher in women when breast reconstruction was combined with mastectomy and whether wound complications delayed the initiation of postoperative chemotherapy.

There were 148 mastectomy procedures among the 128 women whose medical records were reviewed. Sixty-two patients underwent immediate breast reconstruction after their mastectomies, and 81 patients received postoperative chemotherapy.

The overall rate of wound complications was 15.5 percent. The researchers found that 22.3 percent of patients who underwent immediate breast reconstruction after their mastectomies developed wound complications vs. 8.3 percent of patients who did not have immediate breast reconstruction. However, these complications did not interfere with chemotherapy after surgery.

"Although we observed an increased incidence of wound complications when immediate breast reconstruction was combined with mastectomy, there was no delay in the initiation of adjuvant therapy," write the authors. "Immediate breast reconstruction should remain an important treatment option after mastectomy even when postoperative chemotherapy is anticipated."
(Arch Surg. 2004;139:988-991. Available post-embargo at

For more information, contact JAMA/Archives Media Relations at 312-464-JAMA (5262) or e-mail .

To contact corresponding author Richard Bold, M.D., call Claudia Morain at 916-734-9023.

The JAMA Network Journals

Related Breast Cancer Articles from Brightsurf:

Oncotarget: IGF2 expression in breast cancer tumors and in breast cancer cells
The Oncotarget authors propose that methylation of DVDMR represents a novel epigenetic biomarker that determines the levels of IGF2 protein expression in breast cancer.

Breast cancer: AI predicts which pre-malignant breast lesions will progress to advanced cancer
New research at Case Western Reserve University in Cleveland, Ohio, could help better determine which patients diagnosed with the pre-malignant breast cancer commonly as stage 0 are likely to progress to invasive breast cancer and therefore might benefit from additional therapy over and above surgery alone.

Partial breast irradiation effective treatment option for low-risk breast cancer
Partial breast irradiation produces similar long-term survival rates and risk for recurrence compared with whole breast irradiation for many women with low-risk, early stage breast cancer, according to new clinical data from a national clinical trial involving researchers from The Ohio State University Comprehensive Cancer Center - Arthur G.

Breast screening linked to 60 per cent lower risk of breast cancer death in first 10 years
Women who take part in breast screening have a significantly greater benefit from treatments than those who are not screened, according to a study of more than 50,000 women.

More clues revealed in link between normal breast changes and invasive breast cancer
A research team, led by investigators from Georgetown Lombardi Comprehensive Cancer Center, details how a natural and dramatic process -- changes in mammary glands to accommodate breastfeeding -- uses a molecular process believed to contribute to survival of pre-malignant breast cells.

Breast tissue tumor suppressor PTEN: A potential Achilles heel for breast cancer cells
A highly collaborative team of researchers at the Medical University of South Carolina and Ohio State University report in Nature Communications that they have identified a novel pathway for connective tissue PTEN in breast cancer cell response to radiotherapy.

Computers equal radiologists in assessing breast density and associated breast cancer risk
Automated breast-density evaluation was just as accurate in predicting women's risk of breast cancer, found and not found by mammography, as subjective evaluation done by radiologists, in a study led by researchers at UC San Francisco and Mayo Clinic.

Blood test can effectively rule out breast cancer, regardless of breast density
A new study published in PLOS ONE demonstrates that Videssa® Breast, a multi-protein biomarker blood test for breast cancer, is unaffected by breast density and can reliably rule out breast cancer in women with both dense and non-dense breast tissue.

Study shows influence of surgeons on likelihood of removal of healthy breast after breast cancer dia
Attending surgeons can have a strong influence on whether a patient undergoes contralateral prophylactic mastectomy after a diagnosis of breast cancer, according to a study published by JAMA Surgery.

Young breast cancer patients undergoing breast conserving surgery see improved prognosis
A new analysis indicates that breast cancer prognoses have improved over time in young women treated with breast conserving surgery.

Read More: Breast Cancer News and Breast Cancer Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to