Study links higher level of exercise to 25% to 32% lower risk of all-cause mortality in people with type 2 diabetes

September 20, 2020

New research presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD), held online this year, shows that having a greater exercise capacity is associated with a significantly decreased all-cause mortality risk of between 25-33% in people with type 2 diabetes (T2D). The study was conducted by Dr Yun-Ju Lai and colleagues at Puli branch, Taichung Veterans General Hospital, Nantou, Taiwan.

Exercise improves insulin sensitivity, reduces the risk of cardiovascular disease, and inhibits inflammatory cytokines: types of signalling proteins which trigger an inflammatory response. These cytokines are produced by cells of the immune system and are a vital part of how the body responds to the presence of potential disease-causing agents, but excessive chronic production can contribute to inflammatory diseases (which include diabetes). Despite this, the effect of exercise on all-cause mortality in people with T2D has not been fully explored.

The research was based on data drawn from the National Health Interview Survey (NHIS) and the National Health Insurance research database in Taiwan. The NHIS has taken place every four years from 2001 onwards, and details of individuals participating were obtained at baseline through face to face interviews.

The study used information about the characteristics of each participant, including their socioeconomic status, health behaviours, and exercise habits obtained from surveys performed in 2001, 2005, 2009, and 2013. Comorbidities among individuals taking part in the surveys were confirmed by referencing National Health Insurance research database records from 2000-2016, and their health status was followed-up until 31 December 2016. Finally, the team performed statistical analyses to evaluate the relationship between exercise capacity and all-cause mortality, the latter having been determined by referencing the National Registration of Death System in Taiwan.

The details of 4,859 adult Survey participants with T2D were used in the study; 2,389 (49%) were male, and the mean age was 59.5 years. The authors found that those with a higher exercise capacity had a significantly lower risk of all-cause mortality compared with those who reported no exercise habits. Individuals who performed a moderate amount of exercise (defined as 0-800 kcal/week energy expenditure) had a 25% lower all-cause mortality rate, while participants who were classed as having a high exercise level (more than 800 kcal/week energy expenditure) had a 32% lower all-cause mortality risk.

The team conclude: "Among people with type 2 diabetes, those with increased exercise capacity had a significantly decreased risk of all-cause mortality. Further studies should investigate the type and dose of exercise that is most helpful to promote health and prolong life expectancy."


Related Diabetes Articles from Brightsurf:

New diabetes medication reduced heart event risk in those with diabetes and kidney disease
Sotagliflozin - a type of medication known as an SGLT2 inhibitor primarily prescribed for Type 2 diabetes - reduces the risk of adverse cardiovascular events for patients with diabetes and kidney disease.

Diabetes drug boosts survival in patients with type 2 diabetes and COVID-19 pneumonia
Sitagliptin, a drug to lower blood sugar in type 2 diabetes, also improves survival in diabetic patients hospitalized with COVID-19, suggests a multicenter observational study in Italy.

Making sense of diabetes
Throughout her 38-year nursing career, Laurel Despins has progressed from a bedside nurse to a clinical nurse specialist and has worked in medical, surgical and cardiac intensive care units.

Helping teens with type 1 diabetes improve diabetes control with MyDiaText
Adolescence is a difficult period of development, made more complex for those with Type 1 diabetes mellitus (T1DM).

Diabetes-in-a-dish model uncovers new insights into the cause of type 2 diabetes
Researchers have developed a novel 'disease-in-a-dish' model to study the basic molecular factors that lead to the development of type 2 diabetes, uncovering the potential existence of major signaling defects both inside and outside of the classical insulin signaling cascade, and providing new perspectives on the mechanisms behind insulin resistance in type 2 diabetes and possibly opportunities for the development of novel therapeutics for the disease.

Tele-diabetes to manage new-onset diabetes during COVID-19 pandemic
Two new case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in an adult and an infant during the COVID-19 pandemic.

Genetic profile may predict type 2 diabetes risk among women with gestational diabetes
Women who go on to develop type 2 diabetes after having gestational, or pregnancy-related, diabetes are more likely to have particular genetic profiles, suggests an analysis by researchers at the National Institutes of Health and other institutions.

Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).

Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.

People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.

Read More: Diabetes News and Diabetes Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to