High exposure to motor oil increases chances of developing arthritis

September 22, 2005

Occupational exposure to mineral oils, in particular hydraulic or motor oil, increases the risk of developing rheumatoid arthritis by 30%. These are the results of a study published today in Arthritis Research & Therapy.

Berit Sverdrup and Lars Alfredsson, from the Karolinska Institutet in Stockhom, Sweden, and colleagues selected a group of patients diagnosed with rheumatoid arthritis (RA) between May 1996 and December 2003. They matched these patients with people of the same age, gender and residential area, who acted as controls. Shortly after they had been diagnosed with RA, the patients were asked to complete a questionnaire regarding occupational exposure to different types of mineral oils, such as cutting oil, motor oil, form oil, hydraulic oil and asphalt. The same questionnaire was sent to controls.

In total, the study included 1419 cases and 1674 controls. Only men reported high occupational exposure to oil, mostly motor and hydraulic oil. A group of 135 men diagnosed with RA and reporting high exposure, as well as 132 matching controls, was retained for further study.

Sverdrup et al.'s results show that men highly exposed to motor or hydraulic oil have a 30% higher risk of developing RA than unexposed men. Exposure only increased the risk of developing 'rheumatoid factor positive' (RF+) rheumatoid arthritis, a more severe form of RA. It didn't increase the risk of developing rheumatoid factor negative (RF-) rheumatoid arthritis. Exposure to oil is also linked to a 60% increased risk of developing 'anti-citrulline positive' (anti-CP+) rheumatoid arthritis, another type of the disease.

This study confirms results found in animals - exposure to mineral oil had been shown to induce arthritis in rats - and raises questions regarding exposure to other environmental or occupational agents, such as infectious agents that contain molecules that may activate the immune system in similar ways as mineral oils, and a possible link with arthritis.
Article: Association between occupasional exposure to mineral oil and rheumatoid arthritis. Results from the Swedish EIRA case-control study
Berit Sverdrup, Henrik, Camilla Bengtsson, Ingvar Lundberg, Leonid Padyukov, Lars Alfredsson, Lars Klareskog, and the EIRA study group Arthritis Research & Therapy 2005, 7:R1296-R1303 (23 September 2005)

BioMed Central

Related Rheumatoid Arthritis Articles from Brightsurf:

Reducing dementia in patients with rheumatoid arthritis
The incidence of dementia in patients with rheumatoid arthritis is lower in patients receiving biologic or targeted synthetic disease modifying antirheumatic drugs (DMARDs) than in patients who receive conventional synthetic DMARDs, according to a new study.

Is rheumatoid arthritis two different diseases?
While disease activity improves over time for most rheumatoid arthritis (RA) patients, long-term outcomes only improve in RA patients with autoantibodies, according to a new study published this week in PLOS Medicine by Xanthe Matthijssen of Leiden University Medical Center, Netherlands, and colleagues.

Does the Mediterranean diet protect against rheumatoid arthritis?
Previous research has demonstrated a variety of health benefits associated with the Mediterranean diet, which is rich in olive oil, cereals, fruit and vegetables, fish, and a moderate amount of dairy, meat, and wine.

Reducing corticosteroid use in rheumatoid arthritis
Is the long-term use of glucocorticoids essential in people with chronic inflammatory diseases such as rheumatoid arthritis, or can early discontinuation prevent characteristic side effects?

Rheumatoid arthritis patients under treatment with methotrexate
Patients with rheumatoid arthritis (RA) often suffer from what is referred to as interstitial lung disease (ILD).

Rheumatoid arthritis -- can its onset be delayed or prevented?
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that leads to significant health issues as well as high treatment costs.

Disease burden in osteoarthritis is similar to rheumatoid arthritis
Osteoarthritis (OA) has traditionally been viewed as a highly prevalent but milder condition when compared with rheumatoid arthritis (RA), and some may believe that it is part of a normal aging process requiring acceptance, not treatment.

Prospect of a new treatment for rheumatoid arthritis
An international research group led by Charité -- Universitätsmedizin Berlin has completed testing a new drug to treat rheumatoid arthritis.

Can rare lymphocytes combat rheumatoid arthritis?
Immunologists at Friedrich-Alexander-Universität Erlangen-Nürnberg have demonstrated that ILC2, a group of rare lymphoid cells, play a key role in the development of inflammatory arthritis.

Rheumatoid arthritis meets precision medicine
Scientists are bringing precision medicine to rheumatoid arthritis for the first time by using genetic profiling of joint tissue to see which drugs will work for which patients, reports a new multi-site study.

Read More: Rheumatoid Arthritis News and Rheumatoid Arthritis Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.