NIH scientists describe ways to better assess benefits of influenza vaccine in the elderly

September 24, 2007

WHAT: Each year, seasonal flu kills approximately 36,000 people in the United States, most over age 70.Yet little is known about the benefit of influenza vaccine in older seniors. Randomized, placebo-controlled clinical trials involving seniors have not been large enough to reveal how well the vaccine can prevent death in this age group.

In an article in the October issue of The Lancet Infectious Diseases, now available online, researchers from the National Institutes of Health (NIH) describe how sources of bias in other, non-randomized studies have inadvertently resulted in an exaggeration of the flu vaccine's value in preventing flu deaths in the elderly. The authors point to the need for better flu vaccines for seniors, and other strategies to reduce severe influenza outcomes among this age group.

The authors emphasize that even a less-than-ideal influenza vaccine is better than none at all, and that this age group should continue to get a seasonal flu shot. Better vaccines are needed, however, and NIAID supports research to develop new and improved vaccines.

In the meantime, the researchers suggest intensive study of several approaches to reduce influenza-related deaths among the elderly. The researchers also outline new epidemiological methods that may aid in establishing a more accurate picture of the impact on mortality of flu vaccination in the elderly.
-end-
The paper's lead author is Lone Simonsen, Ph.D., formerly of the National Institute of Allergy and Infectious Diseases (NIAID), part of the NIH. Other authors include Mark A. Miller, M.D., of NIH's Fogarty International Center, and Lisa A. Jackson, M.D., of Group Health Center for Health Studies, Seattle.

ARTICLE: "Mortality benefits of influenza vaccination in elderly people: an ongoing controversy," by L. Simonsen et al. The Lancet Infectious Diseases 7: 658-66 (2007). Article available at http://www.thelancet.com/journals/laninf/article/PIIS1473309907702360/fulltext.

SPOKESPERSONS: Lone Simonsen, Ph.D., Visiting Professor, George Washington University, Washington, D.C.
Anthony S. Fauci, M.D., Director, NIAID, NIH
Mark Miller, M.D., Division Director, Fogarty International Center, NIH

CONTACT: To schedule interviews, contact the NIAID News and Public Information Branch, (301) 402-1663, niaidnews@niaid.nih.gov.

NIAID is a component of the National Institutes of Health. NIAID supports basic and applied research to prevent, diagnose and treat infectious diseases such as HIV/AIDS and other sexually transmitted infections, influenza, tuberculosis, malaria and illness from potential agents of bioterrorism. NIAID also supports research on basic immunology, transplantation and immune-related disorders, including autoimmune diseases, asthma and allergies.

The National Institutes of Health (NIH)--The Nation's Medical Research Agency--includes 27 Institutes and Centers and is a component of the U. S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov.

NIH/National Institute of Allergy and Infectious Diseases

Related Vaccines Articles from Brightsurf:

Comprehensive safety testing of COVID-19 vaccines based on experience with prior vaccines
'The urgent need for COVID-19 vaccines must be balanced with the imperative of ensuring safety and public confidence in vaccines by following the established clinical safety testing protocols throughout vaccine development, including both pre- and post-deployment,' write David M.

Safety of HPV vaccines in males
A new analysis published in the British Journal of Clinical Pharmacology shows that HPV vaccines are safe and well tolerated in the male population, and the side effects that may occur after immunization are similar in both sexes.

Model could improve design of vaccines, immunotherapies
Researchers have discovered a general property for understanding how immune cell receptors sense and respond to microbial signals, which could lead to more effective vaccines for both existing and novel viruses.

Better vaccines are in our blood
Red blood cells don't just shuttle oxygen from our lungs to our organs: they also help the body fight off infections by capturing pathogens in the blood and presenting them to immune cells in the spleen.

Challenges in evaluating SARS-CoV-2 vaccines
With more than 140 SARS-CoV-2 vaccines in development, the race is on for a successful candidate to help prevent COVID-19.

Designing vaccines from artificial proteins
EPFL scientists have developed a new computational approach to create artificial proteins, which showed promising results in vivo as functional vaccines.

Misinformation on vaccines readily available online
Parents researching childhood vaccinations online are likely to encounter significant levels of negative information, researchers at the University of Otago, Wellington, have found.

Battle with the cancer: New avenues from childhood vaccines
A new research from the University of Helsinki showed for the first time how the pre-immunization acquired through common childhood vaccines can be used to enhance therapeutic cancer treatment.

Personalized cancer vaccines
The only therapeutic cancer vaccine available on the market has so far showed very limited efficacy in clinical trials.

Doubts raised about effectiveness of HPV vaccines
A new analysis of the clinical trials of HPV vaccines to prevent cervical cancer raises doubts about the vaccines' effectiveness.

Read More: Vaccines News and Vaccines Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.