UMass Amherst neuroscientists see clues to brain maturation in adolescent rats

September 26, 2018

AMHERST, Mass. - One of the outstanding questions in neurodevelopment research has been identifying how connections in the brain change to improve neural function during childhood and adolescence. Now, results from a study in rats just reported by neuroscientists Heather Richardson, Geng-Lin Li and colleagues at the University of Massachusetts Amherst suggest that as animals transition into adolescence, specific physical changes to axons speed up neural transmission, which may lead to higher cognitive abilities.

Their co-author, doctoral candidate Andrea Silva-Gotay, says, "One advantage of increased conduction speed is faster processing of information; brain areas communicate faster and decisions can be made faster." Two factors that can increase conduction speed are myelination and larger axon diameter, she adds. "A thin axon will be slower, a thick one faster. Myelin can also make axons faster."

"To our knowledge, this is the first study that combines measurement of conduction velocity of axons with measurements of myelination during development in this part of the brain," Silva-Gotay points out.

Writing in the journal eNeuro, the researchers report that they have identified specific developmental changes that may be key factors underlying enhanced neural processing in the medial prefrontal cortex (mPFC) of the maturing rat brain. This is a region that integrates information from many sources to process and modulate complex functions such as stress responses, behavior control, attention, and working memory, Richardson says.

She and colleagues studied changes in axons - the long conducting threads of a nerve cell along which signals move from one cell to another - and the wrapping of these axons by myelin - the electrically insulating sheath that forms around nerve fibers at this time - in brains from groups of juvenile, pre-adolescent rats at 15 days old and mid-adolescent rats at 43 days old.

Results suggest that in animals two-to-six weeks old, axons in the mPFC undergo microstructural and electrophysiological changes that speed up neural transmission. Silva-Gotay explains, "Between those two ages we found a significant increase in how fast the electrical signals travel in the brain during pre-adolescence compared to adolescence. There is a dramatic increase. Moreover, we found this in the mPFC, which was not known before."

The authors report that signal conduction velocity in axons nearly doubled by mid-adolescence, and this corresponded with a 90-fold increase in the number of axons that were myelinated in this region. "Because axonal diameter did not change with age, we reason that myelination of these axons accounts for the significant increase in speed," senior author Richardson says. "These axonal changes could contribute to some of the developmental improvements in how well the prefrontal cortex works."

She and Silva-Gotay add that this may tell us something about other brain areas that are being myelinated around this same time in development. Electrical signals could be traveling along axons at a faster pace in these regions as well. "It is also important to consider factors that could interfere with this myelination process. We and others have found that alcohol can reduce myelin in this part of the brain. It is possible that the speed of transmission in these axons was negatively affected as well," Richardson says. "That's something we can test in a future study," adds Silva-Gotay.
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Other authors include co-first authors Sean McDougall and Wanette Vargas Riad, Elizabeth Tavares and Divya Harpalani, all at UMass Amherst when the work was done. Initial support for this study came from two undergraduate Commonwealth Honors College projects by McDougall and Harpalani. The work was also funded by grants from NIH's National Institute on Alcohol Abuse and Alcoholism to Richardson, a National Institute on Deafness and Other Communication Disorders grant to Li and an NIH Post-baccalaureate Research Education Program grant to Vargas Riad.

University of Massachusetts at Amherst

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