Nav: Home

Differences found between smokers and non-smokers who develop lung cancer

September 27, 2015

Amsterdam, The Netherlands: Tobacco smoke is known to be the main risk factor for non-small cell lung cancer (NSCLC), although non-smokers can get it too. The incidence among non-smokers is increasing in many countries. Now a group of Portuguese researchers has found significant differences in clinical particularities and survival between smokers and non-smokers who develop NSCLC.

Dr Cátia Saraiva, from the Department of Pulmonology, of Portuguese Institute of Oncology, Lisbon, Portugal, will tell the European Respiratory Society's International Congress 2015, today (27 September, 2015) that the team studied 504 Portuguese non-smokers with NSCLC, and 904 smokers with the same disease. They found that the non-smoking patients were more likely to be women, with adenocarcinoma (the most common form of NSCLC), with less chronic obstructive pulmonary disease (COPD), heart disease, previous cancer of the larynx and weight loss. They also found that non-smokers had a significant longer survival after diagnosis: 51 months as opposed to 25 months for smokers.

"In Portugal, information on the differences in the risk and survival between smokers and non-smokers with NSCLC, has been very limited up to now," Dr Saraiva said. "Because lung cancer represents a set of tumours with confounding and sometimes misleading symptoms in both smokers and non-smokers, we felt that it was of particular importance to acquire this knowledge. We believe that the differences we found between the two groups will help improve diagnosis, and prompt investigators to try to find out why these differences occur."

"This is the first study to look at the differences in symptoms and prognoses in in non-smokers and smokers with NSCLC in Europe, says Dr Saravia. "We believe that we have made a major contribution towards improving diagnosis and treatment for these patients."

The researchers suggest further prospective studies in order to find different prognostic factors in the areas of ageing, human pre-disposition and life-style between the two groups. "In the non-smoking group, we found professional exposure to carcinogens in 9%, a family history of lung cancer in 5%, and a previous cancer diagnosis in 6%. Additionally, 18% had high blood pressure," Dr Saraiva said.

The non-smoking group were often diagnosed at an advanced stage of disease, 59% of them at stage IV, where the cancer had already spread to other parts of the body, namely different areas in the same lung, the opposite lung, bones, and brain.

"It seems plausible that the non-smoking Portuguese population is not aware of lung cancer risks. But we need to confirm our results through population-based studies, before public education issues can be addressed," says Dr Saravia.

When planning the treatment of NSCLC an additional problem is the simultaneous occurrence of many diseases not directly related to lung cancer. "These co-morbidities increase the difficulties of interpreting clinical symptoms and making decisions about treatment, and mean that we need to fine-tune our clinical practice," says Dr Saraiva. "We hope that our study, involving a significant number of patients, will help that fine-tuning and enable us to tailor treatment more precisely for each individual case."
-end-
Notes to editors:
  • Abstract: Differences in epidemiological and clinical features in non-small cell lung cancer (NSCLC) in never and ever smokers
  • Session: 430 Thematic Poster Diagnosis and therapy of lung cancer
  • Date and time: Tuesday 29 September, 12.50-14.40
  • Room: Hall 14-33


European Lung Foundation

Related Lung Cancer Articles:

AI helps to fight against lung cancer
Lung cancer has been the leading cause of cancer-related deaths in 2015 in United States.
Free lung-cancer screening in the Augusta area finds more than double the cancer rate of previous screenings
The first year of free lung cancer screening in the Augusta, Ga., area found more than double the rate seen in a previous large, national study as well as a Massachusetts-based screening for this No.
Antioxidants and lung cancer risk
An epidemiological study published in Frontiers in Oncology suggests that a diet high in carotenoids and vitamin C may protect against lung cancer.
Lung cancer may go undetected in kidney cancer patients
Could lung cancer be hiding in kidney cancer patients? Researchers with the Harold C.
Hitgen and Cancer Research UK's Manchester Institute enter license agreement in lung cancer
Cancer Research UK, Cancer Research Technology (CRT), the charity's commercial arm, and HitGen Ltd, a privately held biotech company focused on early drug discovery, announced today that they have entered into a licence agreement to develop a novel class of drugs against lung cancer.
More Lung Cancer News and Lung Cancer Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Anthropomorphic
Do animals grieve? Do they have language or consciousness? For a long time, scientists resisted the urge to look for human qualities in animals. This hour, TED speakers explore how that is changing. Guests include biological anthropologist Barbara King, dolphin researcher Denise Herzing, primatologist Frans de Waal, and ecologist Carl Safina.
Now Playing: Science for the People

#534 Bacteria are Coming for Your OJ
What makes breakfast, breakfast? Well, according to every movie and TV show we've ever seen, a big glass of orange juice is basically required. But our morning grapefruit might be in danger. Why? Citrus greening, a bacteria carried by a bug, has infected 90% of the citrus groves in Florida. It's coming for your OJ. We'll talk with University of Maryland plant virologist Anne Simon about ways to stop the citrus killer, and with science writer and journalist Maryn McKenna about why throwing antibiotics at the problem is probably not the solution. Related links: A Review of the Citrus Greening...