Cabazitaxel offers new treatment option for men with advanced and difficult-to-treat prostate cancer

September 30, 2010

Men with advanced, multi-drug resistant prostate cancer can survive a median 2•4 months longer when taking cabazitaxel. Cabazitaxel is the first drug to show a survival benefit in patients whose disease has progressed after standard chemotherapy with docetaxel, and for whom there are currently no approved treatment options. These are the conclusions of an Article published in this week's Cancer Special Issue of The Lancet. On the basis of these results, cabazitaxel has been given regulatory approval in the USA and is under consideration by the European Medicines Agency and other regulatory bodies.

Prostate cancer is the second most common cancer in men worldwide. For men with advanced prostate cancer, hormone therapy improves symptoms but for many patients their disease continues to progress. Docetaxel plus prednisone is the gold-standard chemotherapy treatment for these patients. But for men whose cancer becomes docetaxel resistant there is currently no treatment available that can prolong survival. However, until now, mitoxantrone was often given because of its beneficial effects on quality of life.

The new chemotherapy drug cabazitaxel has shown promising antitumour activity in patients whose cancer has progressed after docetaxel treatment.

To assess whether cabazitaxel improves overall survival compared with mitoxantrone in men with advanced multi-drug resistant prostate cancer (who had already been treated with docetaxel), an international team led by Johann de Bono, from the Royal Marsden NHS Foundation and The Institute of Cancer Research in the UK, conducted the phase 3 TROPIC trial.

755 patients were enrolled from 146 centres across 26 countries and randomly assigned to mitoxantrone (377) or cabazitaxel (378), both in combination with prednisone. The median overall survival was 15•1 months in the cabazitaxel group compared with 12•7 months in the mitoxantrone group.

The authors say: "Cabazitaxel treatment also improved median progression-free survival and time to tumour progression, and resulted in higher rates of tumour and serum prostate-specific antigen (PSA) response than did mitoxantrone."

Adverse events were seen more often in patients taking cabazitaxel. The most common grade 3 or higher side effects found in patients in the cabazitaxel group compared with the mitoxantrone were neutropenia (82% vs 58%) and diarrhoea (6% vs <1%). Additionally, 28 patients taking cabazitaxel had febrile neutropenia compared with 5 taking mitoxantrone.

They conclude: "Cabazitaxel is the first treatment to prolong survival for metastatic multi-drug-resistant prostate cancer in the post-docetaxel setting...On the basis of these results, cabazitaxel will become a standard of care for treatment of prostate cancer in this setting."

In a Comment, Tanya Dorff and David Quinn from The University of Southern California, Los Angeles, USA, say: "Cabazitaxel provides an added line of therapy for patients with castration-resistant prostate cancer...The horizon for patients with prostate cancer is promising...Therapeutic strategies in phase 3 testing include more potent suppression of androgen-receptor signalling, modulation of novel pathways in bone metastases (which afflict more than 90% of men with advanced prostate cancer), and increased anti-tumour immunity."
Dr Johann de Bono, Royal Marsden NHS Foundation and The Institute of Cancer Research, Surrey, UK. Via ICR Science Press Officer Jane Bunce T) +44 (0)207 153 5106 E)

Dr David Quinn, University of Southern California, Los Angeles, USA. Via Leslie Ridgeway, Public Relations, USC Health Sciences. T) +1 (323) 442 2823 or +1 (213) 200 8015 E)

For full Article and Comment see:



Related Prostate Cancer Articles from Brightsurf:

Low risk of cancer spread on active surveillance for early prostate cancer
Men undergoing active surveillance for prostate cancer have very low rates - one percent or less - of cancer spread (metastases) or death from prostate cancer, according to a recent study published in the Journal of Urology®, an Official Journal of the American Urological Association (AUA).

ESMO 2020: Breast cancer drug set to transform prostate cancer treatment
A drug used to treat breast and ovarian cancer can extend the lives of some men with prostate cancer and should become a new standard treatment for the disease, concludes a major trial which is set to change clinical practice.

Major trial shows breast cancer drug can hit prostate cancer Achilles heel
A drug already licensed for the treatment of breast and ovarian cancers is more effective than targeted hormone therapy at keeping cancer in check in some men with advanced prostate cancer, a major clinical trial reports.

The Lancet: Prostate cancer study finds molecular imaging could transform management of patients with aggressive cancer
Results from a randomised controlled trial involving 300 prostate cancer patients find that a molecular imaging technique is more accurate than conventional medical imaging and recommends the scans be introduced into routine clinical practice.

Common genetic defect in prostate cancer inspires path to new anti-cancer drugs
Researchers found that, in prostate cancer, a mutation leading to the loss of one allele of a tumor suppressor gene known as PPP2R2A is enough to worsen a tumor caused by other mutations.

First prostate cancer therapy to target genes delays cancer progression
For the first time, prostate cancer has been treated based on the genetic makeup of the cancer, resulting in delayed disease progression, delayed time to pain progression, and potentially extending lives in patients with advanced, metastatic prostate cancer, reports a large phase 3 trial.

Men taking medications for enlarged prostate face delays in prostate cancer diagnosis
University of California San Diego School of Medicine researchers report that men treated with medications for benign prostatic hyperplasia (enlarged prostate) experienced a two-year delay in diagnosis of their prostate cancer and were twice as likely to have advanced disease upon diagnosis.

CNIO researchers confirm links between aggressive prostate cancer and hereditary breast cancer
The study has potential implications for families with members suffering from these types of tumours who are at an increased risk of developing cancer.

Distinguishing fatal prostate cancer from 'manageable' cancer now possible
Scientists at the University of York have found a way of distinguishing between fatal prostate cancer and manageable cancer, which could reduce unnecessary surgeries and radiotherapy.

Researchers find prostate cancer drug byproduct can fuel cancer cells
A genetic anomaly in certain men with prostate cancer may impact their response to common drugs used to treat the disease, according to new research at Cleveland Clinic.

Read More: Prostate Cancer News and Prostate Cancer Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to