Study to investigate menstrual blood-derived stem cells as potential stroke therapy

September 30, 2010

Tampa, Fla. (Sept 30, 2010) - The potential for stem cells derived from menstrual blood to benefit stroke sufferers will be jointly investigated by researchers at the University of South Florida, Cryo-Cell International, Inc., a global stem cell company based in Oldsmar, FL, and Saneron CCEL Therapeutics, Inc. a Tampa-based biotechnology company. The research team is supported by a $100,000 grant from the Florida-based Technology Transfer/ Commercialization Partnership Grant through the James and Esther King Biomedical Research Program, and a Florida Hi-Tech Corridor Industry Seed Matching Grant from USF Connect for another $52,000.

"Recent laboratory studies using animal models have shown transplanted menstrual blood-derived stem cells produced therapeutic effects following stroke," said Dr. Cesar Borlongan, co-principal investigator and a USF neuroscientist. "We will be testing the possibility that these cells promote the growth of blood vessels and neurons that can aid in brain repair following stroke."

In previous animals studies using transplanted stem cells from menstrual blood, Dr. Borlongan and his research team found that the cells were safe and, unlike embryonic stem cells, did not run the risk of creating tumors. In their next stage of study under the new grant, the researchers will transplant menstrual blood-derived stem cells (alone as well as conditioned and treated in a variety of ways) to determine the molecular and cellular components involved in repairing damage following stroke induced chemically in laboratory mice.

"Our long-term goal is to advance the clinical application of self-donor (autologous) cell therapy for stroke," said Dr. Borlongan, who serves as a consultant to Saneron-CCEL.

Menstrual blood is a novel and plentiful source of stem cells with great potential for differentiation into a variety of cell types, according to the researchers.

"Menstrual blood offers an adult stem cell alternative that circumvents the ethical and logistical limitations of embryonic stem cells and their retrieval offers greater ease, and with a wider window of opportunity for harvest than other adult stem cells," concluded Dr. Borlongan.

"This project is a natural extension of ongoing collaborative research efforts between Saneron, USF, and Cryo-Cell over the last 10 years. The menstrual blood-derived stem cells provide a renewable source of adult stem cells that is easily obtainable," said Nicole Kuzmin-Nichols, co-principal investigator and Saneron president and chief operating officer. "This study was designed as a proof of concept study, that when combined with other ongoing studies may lay the foundation for a future clinical trial using these cells as a potential therapy for stroke patients."

"Menstrual blood-derived stem cells have already demonstrated significant promise in preclinical studies to treat a variety of conditions," said Dr. Julie Allickson, Cryo-Cell's vice president of laboratory operations and research and development. "We look forward to gaining further insights from this exciting research investigation that may possibly lead to future potential therapeutic applications for the treatment of stroke."
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About USF Health

USF Health (www.health.usf.edu) is dedicated to creating a model of health care based on understanding the full spectrum of health. It includes the University of South Florida's colleges of medicine, nursing, and public health; the schools of biomedical sciences as well as pharmacy, and physical therapy & rehabilitation sciences; and the USF Physicians Group. With more than $394.1 million in research grants and contracts in FY2009/2010, the University of South Florida is one of the nation's top 63 public research universities and one of only 25 public research universities nationwide with very high research activity that is designated as community-engaged by the Carnegie Foundation for the Advancement of Teaching.

About Saneron CCEL Therapeutics, Inc.

Saneron is a biotechnology R&D company, focused on neurological and cardiac cell therapy for the early intervention and treatment of several devastating or deadly diseases, which lack adequate treatment options. Saneron, a University of South Florida spin-out company is located at the Tampa Bay Technology Incubator. An affiliate of Cryo-Cell International, Inc., Saneron is committed to providing readily available, non-controversial stem cells for cellular therapies and has patented and patent-pending technology relating to our platform technology of umbilical cord blood and Sertoli cells.

For further information please contact:
Saneron CCEL Therapeutics Inc.,
Nicole Kuzmin-Nichols, MBA
3802 Spectrum Blvd., Suite 147
Tampa, FL 33612
Phone: 813-977-7664 x2
nkn@saneron-ccel.com

About Cryo-Cell International, Inc. -(OTCBB:CCEL - News)

Based in Oldsmar, Florida, with nearly 215,000 clients worldwide, Cryo-Cell is one of the largest and most established family cord blood banks. ISO 9001:2008 certified and accredited by the AABB, Cryo-Cell operates in a state-of-the-art Good Manufacturing Practice and Good Tissue Practice (cGMP/cGTP)-compliant facility. Cryo-Cell is a publicly traded company. OTC Bulletin Board Symbol: CCEL. For more information, please call 1-800-STOR-CELL (1-800-786-7235) or visit www.cryo-cell.com.

University of South Florida (USF Health)

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