New radiation treatment for large tumors

September 30, 1999

LEXINGTON, KY (Sept. 30, 1999) - A type of radiation treatment developed at the University of Kentucky Chandler Medical Center - and used only at UK - has been found to reduce the size of large, very advanced tumors.

Results of a study of the Spatially Fractionated Radiation Therapy (GRID therapy) are published in the Sept. 30 issue of the International Journal of Radiation Oncology.

The study's principal investigator, Mohammed Mohiuddin, M.D., professor and chair, Department of Radiation Medicine, UK College of Medicine, developed the technique about 12 years ago to treat large cancers that tend not to respond to conventional treatment. UK is the only institution in the world offering the treatment.

GRID therapy is based on methods used in the 1950s when a sieve-like device was used to treat small, deeply seated tumors with a high dose of radiation. GRID therapy allows for a five to 10-times greater dose than the daily conventional dose of radiation. Mohiuddin also found that the treatment produces a "bystander effect."

"Using this technique, we're finding that not only is the direct effect of the radiation good, but it also produces in tumors products that act as agents to kill other cancer cells," he said. Such an effect is not found with conventional treatment.

"In the past 12 years, we have adapted that technique and use it in combination with the high energy X-rays available now," Mohiuddin said. "Instead of using one large beam of radiation, we used 250 smaller, concentrated pencil-sized beams."

In the study, 92 percent of the 70 patients treated with GRID therapy and simultaneous external radiation therapy responded to the treatment. In many cases, the treatment eased pain or helped shrink the tumor so that surgery could be performed.

Also, even with the high doses of radiation used with the technique, few effects of radiation, such as burns, are apparent.

The response in more than 70 patients treated with GRID therapy between 1995 and 1998 has been very dramatic, Mohiuddin said. Nationally, radiation medicine specialists are looking to the technique as a possible way to attack other hard-to-treat cancers.
-end-


University of Kentucky Medical Center

Related Radiation Articles from Brightsurf:

Sheer protection from electromagnetic radiation
A printable ink that is both conductive and transparent can also block radio waves.

What membrane can do in dealing with radiation
USTC recently found that polymethylmethacrylate (PMMA) and polyvinyl chloride (PVC) can release acidic substance under γ radiation, whose amount is proportional to the radiation intensity.

First measurements of radiation levels on the moon
In the current issue (25 September) of the prestigious journal Science Advances, Chinese and German scientists report for the first time on time-resolved measurements of the radiation on the moon.

New biomaterial could shield against harmful radiation
Northwestern University researchers have synthesized a new form of melanin enriched with selenium.

A new way to monitor cancer radiation therapy doses
More than half of all cancer patients undergo radiation therapy and the dose is critical.

Nimotuzumab-cisplatin-radiation versus cisplatin-radiation in HPV negative oropharyngeal cancer
Oncotarget Volume 11, Issue 4: In this study, locally advanced head and neck cancer patients undergoing definitive chemoradiation were randomly allocated to weekly cisplatin - radiation {CRT arm} or nimotuzumab -weekly cisplatin -radiation {NCRT arm}.

Breaking up amino acids with radiation
A new experimental and theoretical study published in EPJ D has shown how the ions formed when electrons collide with one amino acid, glutamine, differ according to the energy of the colliding electrons.

Radiation breaks connections in the brain
One of the potentially life-altering side effects that patients experience after cranial radiotherapy for brain cancer is cognitive impairment.

Fragmenting ions and radiation sensitizers
The anti-cancer drug 5-fluorouracil (5FU) acts as a radiosensitizer: it is rapidly taken up into the DNA of cancer cells, making the cells more sensitive to radiotherapy.

'Seeing the light' behind radiation therapy
Delivering just the right dose of radiation for cancer patients is a delicate balance in their treatment regime.

Read More: Radiation News and Radiation Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.