Going from strength to strength: effects of growth hormone on muscle

October 01, 2010

Growth hormone is used to treat children's growth disorders and has been used by some sports men and women to promote muscle growth and regeneration. This is because it coordinates skeletal muscle development, nutrient uptake, and nutrient utilization. It is not clear, however, which of these effects are direct and which are indirectly mediated via growth hormone induction of the protein IGF-1. Now, however, a team of researchers, led by Thomas Clemens, at Johns Hopkins University School of Medicine, Baltimore, has used mice engineered to lack in their skeletal muscle either the molecule to which growth hormone binds or the molecule to which IGF-1 binds to show that growth hormone control of skeletal muscle development is dependent on IGF-1, whereas its control of nutrient uptake is independent of IGF-1. The authors hope that with additional work, these results will guide more informed use of growth hormone or growth hormone analogs for promoting muscle development and reducing muscle loss.
-end-
TITLE: Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice

AUTHOR CONTACT:
Thomas L. Clemens
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Phone: 410.955.3245; Fax: 410.614.1451; E-mail: tclemen5@jhmi.edu.

View this article at: http://www.jci.org/articles/view/42447?key=0f67533b542cb2ccea78

JCI Journals

Related Growth Hormone Articles from Brightsurf:

Growth hormone plays key role in early puberty, breast cancer risk
Girls who enter puberty early in life--as measured by early breast development and age of first menstrual period--have a longer window of susceptibility to breast cancer.

Human growth hormone treatment after ACL injury may prevent loss of muscle strength
A new study finds the use of HGH treatment in patients that have undergone ACL reconstructive surgery may prevent the loss of muscle strength and weakness.

Liver surgery success boosted by growth hormone
Growth hormone has been identified as playing a key role in reducing inflammation and increasing survival rates following liver surgery.

Growth hormone acts to prevent weight loss
A Brazilian study shows that, like leptin, growth hormone contributes directly to energy conservation when the body loses weight.

Cost savings from growth hormone insurance strategies not passed on to patients
Increasingly aggressive insurance strategies have lowered the total costs and insurance costs of growth hormone drugs, but those savings are not being passed on to patients, according to new research to be presented Sunday at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, La.

Patients bear increased financial burden for growth hormone treatment despite FDA approval
Despite an FDA approval of growth hormone treatment for children with idiopathic short stature (ISS), the mean cost burden to patients and their families has increased over time.

Growth hormone may provide new hope for stroke survivors
Less fatigue and better recovery of cognitive abilities such as learning and memory.

FASEB Science Research Conference: Growth Hormone/Prolactin
This SRC will bring together international scientists from academia and industry for lively discussions on the latest developments in the growth hormone (GH)/prolactin (PRL) family of hormones and their clinical applications.

Low thyroid hormone before birth alters growth and development of fetal pancreas
Levels of thyroid hormone in babies influences insulin-secreting cells of the pancreas, according to a new study published in The Journal of Physiology.

When should doctors treat short children and teens with growth hormone?
When is it appropriate to treat short children with growth hormone?

Read More: Growth Hormone News and Growth Hormone Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.