Yo-yoing weight, blood pressure, cholesterol and blood sugar readings may raise heart attack and stroke risk

October 01, 2018

DALLAS, Oct. 1, 2018 -- Fluctuations in weight, blood pressure, cholesterol and/or blood sugar levels in otherwise healthy people may be associated with a higher risk of heart attack, stroke and death from any cause compared to people with more stable readings, according to new research in the American Heart Association's journal Circulation.

This is the first study to suggest that high variability of these risk factors has a negative impact on relatively healthy people. The study is also the first to indicate that having multiple measures with high variability adds to the risk.

Compared to people who had stable measurements during an average 5.5 year follow-up period, those with the highest amount of variability (in the upper 25 percent) on all measurements were: Using data from the Korean National Health Insurance system, researchers examined data on 6,748,773 people who had no previous heart attacks and were free of diabetes, high blood pressure, or high cholesterol at the beginning of the study. All participants had at least three health examinations between 2005 and 2012 (every two years is recommended in the system). Records of the exams documented body weight, fasting blood sugar, systolic (top number) blood pressure and total cholesterol.

Because high variability could result from either positive or negative changes, the researchers looked separately at the effect of variability in participants who were more than 5 percent improved or worsened on each measurement. In both the improved and the worsened groups, high variability was associated with a significantly higher risk of death.

"Healthcare providers should pay attention to the variability in measurements of a patient's blood pressure, cholesterol and glucose levels as well as body weight. Trying to stabilize these measurements may be an important step in helping them improve their health," said Seung-Hwan Lee, M.D., Ph.D., senior author of the study and professor of endocrinology at the College of Medicine of the Catholic University of Korea in Seoul, South Korea.

The study was observational, which means that it cannot prove a cause-and-effect relationship between high variability and the risk of heart attacks, strokes or death from any cause. The study also did not delve into the reasons behind the fluctuations in the participants' risk factor measurements.

"It is not certain whether these results from Korea would apply to the United States. However, several previous studies on variability were performed in other populations, suggesting that it is likely to be a common phenomenon," Lee said.
-end-
Co-authors are Mee Kyoung Kim, M.D., Ph.D.; Kyungdo Han, Ph.D.; Yong-Moon Park, M.D., Ph.D.; Hyuk-Sang Kwon, M.D., Ph.D.; Gunseog Kang, Ph.D.; and Kun-Ho Yoon, M.D., Ph.D. Author disclosures are on the manuscript.

The National Research Foundation of Korea funded the study.

Additional Resources: Statements and conclusions of study authors published in American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect the association's policy or position. The Association makes no representation or guarantee as to their accuracy or reliability. The Association receives funding primarily from individuals. Foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The Association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations and health insurance providers are available at https://www.heart.org/en/about-us/aha-financial-information.

About the American Heart Association

The American Heart Association is devoted to saving people from heart disease and stroke - the two leading causes of death in the world. We team with millions of volunteers to fund innovative research, fight for stronger public health policies and provide lifesaving tools and information to prevent and treat these diseases. The Dallas-based association is the nation's oldest and largest voluntary organization dedicated to fighting heart disease and stroke. To learn more or to get involved, call 1-800-AHA-USA1, visit heart.org or call any of our offices around the country. Follow us on Facebook and Twitter.

American Heart Association

Related Blood Pressure Articles from Brightsurf:

Children who take steroids at increased risk for diabetes, high blood pressure, blood clots
Children who take oral steroids to treat asthma or autoimmune diseases have an increased risk of diabetes, high blood pressure, and blood clots, according to Rutgers researchers.

High blood pressure treatment linked to less risk for drop in blood pressure upon standing
Treatment to lower blood pressure did not increase and may decrease the risk of extreme drops in blood pressure upon standing from a sitting position.

Changes in blood pressure control over 2 decades among US adults with high blood pressure
National survey data were used to examine how blood pressure control changed overall among U.S. adults with high blood pressure between 1999-2000 and 2017-2018 and by age, race, insurance type and access to health care.

Transient increase in blood pressure promotes some blood vessel growth
Blood vessels are the body's transportation system, carrying oxygen and nutrients to cells and whisking away waste.

Effect of reducing blood pressure medications on blood pressure control in older adults
Whether the amount of blood pressure medications taken by older adults could be reduced safely and without a significant change in short-term blood pressure control was the objective of this randomized clinical trial that included 534 adults 80 and older.

Brain blood flow sensor discovery could aid treatments for high blood pressure & dementia
A study led by researchers at UCL has discovered the mechanism that allows the brain to monitor its own blood supply, a finding in rats which may help to find new treatments for human conditions including hypertension (high blood pressure) and dementia.

Here's something that will raise your blood pressure
The apelin receptor (APJ) has been presumed to play an important role in the contraction of blood vessels involved in blood pressure regulation.

New strategy for treating high blood pressure
The key to treating blood pressure might lie in people who are 'resistant' to developing high blood pressure even when they eat high salt diets, shows new research published today in Experimental Physiology.

Arm cuff blood pressure measurements may fall short for predicting heart disease risk in some people with resistant high blood pressure
A measurement of central blood pressure in people with difficult-to-treat high blood pressure could help reduce risk of heart disease better than traditional arm cuff readings for some patients, according to preliminary research presented at the American Heart Association's Hypertension 2019 Scientific Sessions.

Heating pads may lower blood pressure in people with high blood pressure when lying down
In people with supine hypertension due to autonomic failure, a condition that increases blood pressure when lying down, overnight heat therapy significantly decreased systolic blood pressure compared to a placebo.

Read More: Blood Pressure News and Blood Pressure Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.