Exposure to BPA in the womb linked to wheezing and poorer lung function in children

October 01, 2019

Madrid, Spain: Pregnant women exposed to higher levels of the commonly used chemical bisphenol A (BPA) are more likely to have children who suffer with wheezing and poorer lung function, according to research presented at the European Respiratory Society International Congress. [1]

BPA is one of a group of chemicals called phenols that are used in the manufacture of food containers, cans, plastic bottles, toys and some types of paper. Previous research suggests that phenols can interfere with hormone signals in the body.

The new research examined pregnant women's exposure to various phenols and found that the majority of women in the study had detectable levels of BPA in their urine. Children born to women with higher levels of BPA were more likely to have smaller lung capacity and to experience wheezing.

The study was presented by Alicia Abellan, a predoctoral researcher at the Barcelona Institute for Global Health (ISGlobal), a centre supported by the "la Caixa" Foundation. She said: "Phenols are chemicals that we are continuously exposed to in our daily lives and BPA is the most commonly used phenol.

"Phenols are known to be 'endocrine disruptors', which means they can interfere with the hormone system and consequently alter many essential body functions, including the respiratory and immune systems.

"When babies are still in the womb, they are especially vulnerable to these substances because they have not yet established the ability to remove toxic substances, and their respiratory and immune systems are still developing."

Ms Abellan and her colleagues studied 2685 pairs of mothers and their children who were already taking part in one of eight large European research projects. Levels of the mothers' exposure to BPA and other phenols were gauged from a urine sample taken during pregnancy. The children's lung function was measured when they were aged between six and ten years. Questionnaires were also used to determine whether children suffered with wheezing.

The results showed that 79% of the pregnant women had detectable quantities of BPA in their urine. Other less commonly used phenols, such as bisphenol S and bisphenol F, were also found but in fewer women. Researchers discovered that women with higher levels of BPA were 13% more likely to have children who suffered with wheezing. They also found that a doubling of BPA in a mother's urine sample corresponded with an estimated 5ml decrease in a child's lung capacity.

The researchers say their results are strengthened by the fact that they collated data from eight different European studies including a large number of participants. However, they say a potential weakness of the work is that they had to rely on measurements of phenols from just one or two urine samples per woman, which only gives a snapshot of recent exposure.

Ms Abellan said: "Our research doesn't tell us exactly how the two are linked, but previous research in animals has shown that prenatal exposure to BPA can stunt the developing lungs and have an impact on the immune system. It could be that these chemicals interact with hormone signals in the growing baby and alter the correct development of the immune and the respiratory systems.

"Currently, there is no general consensus regarding a safe level of exposure to phenols, but recently the EU general court classified BPA among the list of 'very high concern' chemicals."

Ms Abellan and her colleagues plan to continue this work by analysing BPA exposure and its effects on different wheezing patterns across childhood, as well as studying the effects of the other phenols that they found in lower concentrations.

Professor Daiana Stolz, from University Hospital Basel, Switzerland, is Chair of the European Respiratory Society Education Council and was not involved in the study. She said: "This research suggests that exposure to BPA in the womb may lead to small but measurable differences in children's lung function. These effects might not have much impact on children who are otherwise healthy, but they are very important when we consider the health of a whole population.

"Policy makers and clinicians should be aware of the role that these commonly used chemicals might play in the very earliest stages of a baby's development and the impact that could have on our population's health at later stages of life, as we know that having lower lung function in early life makes people more prone to developing chronic lung diseases like COPD.

"Further investigation is needed to confirm the link between phenol exposure and respiratory effects, as well as more research to assess the mixtures of chemicals in our environment and their effects on respiratory health."
-end-


European Lung Foundation

Related Lung Function Articles from Brightsurf:

Exercised over nothing: Masks don't impair lung function during physical activity
A team of American and Canadian researchers report that while they may feel uncomfortable, there is little empirical evidence that wearing a facemask significantly diminishes lung function, even when worn during heavy exercise.

Lung, immune function in kids could protect from severe COVID-19
Differences in lung physiology and immune function in children could be why they are more often spared from severe illness associated with COVID-19 than adults.

Identification of new factors important in maintaining lung function in the elderly
Japanese researchers have found that elderly carriers of a specific DsbA-L gene type are at increased risk for lung function decline.

Weight gain associated with accelerated lung function decline in adulthood
Lung function declines naturally over the course of the human lifespan.

Inhaled immunosuppressant may increase survival, pulmonary function after lung transplant
University of Maryland School of Medicine researchers found that lung transplant recipients who had early signs of organ rejection could increase their chances of survival by inhaling a liposomal form of the immunosuppression drug cyclosporine through an investigational nebulizer.

Exposure to BPA in the womb linked to wheezing and poorer lung function in children
Pregnant women exposed to higher levels of the commonly used chemical bisphenol A (BPA) are more likely to have children who suffer with wheezing and poorer lung function, according to research presented at the European Respiratory Society International Congress.

Exposure to outdoor air pollutants, change in emphysema, lung function
Whether exposure to outdoor air pollutants is associated with emphysema progression and change in lung function was the focus of this observational study.

Girls who are more physically active in childhood may have better lung function in adolescence
A study of more than 2,300 adolescents underscores the pulmonary health benefits of physical activity.

Exposure to chemicals before and after birth is associated with a decrease in lung function
A European study, published in The Lancet Planetary Health, analyses for the first time the impact of the exposome on respiratory health.

Common e-cigarette chemical flavorings may impair lung function
Two chemicals widely used to flavor electronic cigarettes may be impairing the function of cilia in the human airway, according to a new study led by Harvard T.H.

Read More: Lung Function News and Lung Function Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.