Nav: Home

Are organ transplant recipients at greater risk of death from COVID-19?

October 01, 2020

ANN ARBOR, Mich. - A new study, published in Transplantation, finds that risk of death from COVID-19 in organ transplant recipients may be based upon how the patient was treated.

"Using data from the
Sharma says the demographics of patients included in the study were also consistent with COVID-19 patient trends throughout the state of Michigan.

"Black Michiganders represent 15% of the total population in the state and account for 42% of COVID-19-related deaths, compared to white Michiganders who represent 75% of the population in the state and 26% of deaths from COVID-19," she says.

"These statistics are also valid for solid organ transplant recipients, and while Black patients account for one tenth of all organ transplant recipients in our

The research team found that disease severity and intubation rates were similar among both solid organ transplant recipients and non-transplant patients, but organ transplant recipients needed more renal replacement therapy, which takes over functioning for the kidneys when they are failing.

While death due to severity of the virus was similar in both groups, the use of hydroxychloroquine treatment was associated with higher death rates among the organ transplant recipients.

"In fact, we found that the treatment of hydroxychloroquine among organ transplant recipients was associated with ten-fold higher risk of death compared to not using the treatment among the recipients," Sharma says.
-end-
Sharma and her colleagues hope that these findings encourage further scrutiny of hydroxychloroquine use in organ transplant recipients infected with COVID-19.

The study research team led by Sharma includes Michigan Medicine researchers from five divisions/units: Vincent Chen, M.D., Vaiibhav Patel, M.D., Michael Combs, M.D., Silas Norman, M.D., Puneet Garg, M.D., Monica Colvin, M.D., Jonathan Golob, M.D., Ph.D., Monica Doshi, M.D., and Keith Aaronson, M.D., M.S., of the Department of Internal Medicine; Christopher Sonnenday, M.D., MHS, of the Department of Surgery; Christopher Fung, M.D., of the Department of Emergency Medicine; Emily Somers, Ph.D., of the U-M School of Public Health; and Jonathan Troost, Ph.D., of the Michigan Institute for Clinical and Health Research.

Michigan Medicine - University of Michigan

Related Transplantation Articles:

A revolutionary new treatment alternative to corneal transplantation
A new approach in ophthalmology that offers a revolutionary alternative to corneal transplantation has just been developed by researchers and clinicians in North America, Europe, and Oceania.
Fewer complications after organ transplantation
A large international study coordinated by University Hospital Regensburg and Charité - Universitätsmedizin Berlin has demonstrated the safety of new cell therapy approaches for use in kidney transplant recipients.
Elderly patients also benefit from kidney transplantation
So far, kidney transplantation has generally not been offered to elderly patients (>75 years) because of the perioperative risks.
New material will allow abandoning bone marrow transplantation
Scientists from the National University of Science and Technology 'MISIS' developed nanomaterial, which will be able to restore the internal structure of bones damaged due to osteoporosis and osteomyelitis.
Fewer medical tests -- timely listing for transplantation
Younger patients would benefit greatly from kidney transplantation. Their expected remaining lifetime may even be doubled by having a transplant.
Uterus transplantation -- ethically just as problematic as altruistic surrogacy
In 2014, the first child to have been gestated in a donated uterus was born.
Advancing transplantation: Hepatitis C-infected organs safe for transplantation when followed by antiviral treatment
Twenty patients at Penn Medicine have been cured of the hepatitis C virus (HCV) following lifesaving kidney transplants from deceased donors who were infected with the disease, according to a study published today in Annals of Internal Medicine.
Transplantation followed by antiviral therapy cured hepatitis C
Twenty patients who received kidneys transplanted from hepatitis C virus (HCV)-infected donors experienced HCV cure, good quality of life, and excellent renal function at one year.
The Journal of Heart and Lung Transplantation: 50 years of heart transplantation progress
This month marks the 50th anniversary of the world's first human heart transplant performed at Groote Schuur Hospital in Cape Town by South African surgeon, Christiaan Barnard.
Older donor lungs should be considered for transplantation
With a scarcity of lungs available for transplantation, the use of lungs from donors older than age 60 has been shown to achieve reasonable outcomes and should be considered as a viable option, according to research published online today in The Annals of Thoracic Surgery.
More Transplantation News and Transplantation Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: The Power Of Spaces
How do spaces shape the human experience? In what ways do our rooms, homes, and buildings give us meaning and purpose? This hour, TED speakers explore the power of the spaces we make and inhabit. Guests include architect Michael Murphy, musician David Byrne, artist Es Devlin, and architect Siamak Hariri.
Now Playing: Science for the People

#576 Science Communication in Creative Places
When you think of science communication, you might think of TED talks or museum talks or video talks, or... people giving lectures. It's a lot of people talking. But there's more to sci comm than that. This week host Bethany Brookshire talks to three people who have looked at science communication in places you might not expect it. We'll speak with Mauna Dasari, a graduate student at Notre Dame, about making mammals into a March Madness match. We'll talk with Sarah Garner, director of the Pathologists Assistant Program at Tulane University School of Medicine, who takes pathology instruction out of...
Now Playing: Radiolab

What If?
There's plenty of speculation about what Donald Trump might do in the wake of the election. Would he dispute the results if he loses? Would he simply refuse to leave office, or even try to use the military to maintain control? Last summer, Rosa Brooks got together a team of experts and political operatives from both sides of the aisle to ask a slightly different question. Rather than arguing about whether he'd do those things, they dug into what exactly would happen if he did. Part war game part choose your own adventure, Rosa's Transition Integrity Project doesn't give us any predictions, and it isn't a referendum on Trump. Instead, it's a deeply illuminating stress test on our laws, our institutions, and on the commitment to democracy written into the constitution. This episode was reported by Bethel Habte, with help from Tracie Hunte, and produced by Bethel Habte. Jeremy Bloom provided original music. Support Radiolab by becoming a member today at Radiolab.org/donate.     You can read The Transition Integrity Project's report here.