Leptin Regulates Hunger During Energy Deficit In Women

October 01, 1998

Background: On the basis of observations in rodents, leptin is thought to play a key role in the regulation of energy expenditure and food intake, but less is known of its influence on ingestive behavior and energy balance in humans.

Objective: We examined the effect in women of a chronic energy deficit on plasma leptin concentrations and self-reported appetite and explored possible relations between leptin and appetite sensations.

Design: Twelve healthy women (body mass index, in kg/m2: 23-37) participated in a metabolic ward study in which 3 wk of neutral energy balance was followed by 12 wk of energy deficit (energy intake reduced by 2 MJ/d and energy expenditure increased by 0.8 MJ/d). Body weight and composition were monitored, fasting leptin concentrations were measured 4 times, and feelings of hunger, fullness, desire to eat, and prospective consumption were monitored hourly throughout the day on 7 selected days.

Results: Adiposity-adjusted leptin decreased by 54% after 1 wk of a moderate energy deficit and remained low after 6 and 12 wk. Leptin was associated with self-reported hunger, desire to eat, and prospective consumption (range of r: -0.6 to -0.7, P< 0.01). The greatest hunger increase coincided with the largest percentage drop in circulating leptin and the lowest final leptin concentration. The relation between leptin and hunger was not influenced by amount of weight or body fat loss.

Conclusions: These findings support the idea that leptin is a physiologic regulator of hunger during energy deficits in humans; the role of leptin in the long-term regulation of food intake warrants further study.

###


Am J Clin Nutr 1998;68:794-801.

Key words: Energy intake, energy expenditure, appetite, hunger, satiety, women, weight loss, leptin

From the US Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, San Francisco; the Department of Nutrition, University of California-Davis; and the Department of Internal Medicine, University of California-Davis.



American Journal of Clinical Nutrition

Related Nutrition Articles from Brightsurf:

Here's how to improve packaged foods nutrition
FOP nutrition labeling results in a significant improvement in the nutritional quality of food products.

'Front of package' nutrition labels improved nutrition quality
A new study analyzing 16 years of data on tens of thousands of products finds that the adoption of nutrition data on ''front of package'' labels is associated with improved nutritional content of those foods and their competitors.

Aquaculture's role in nutrition in the COVID-19 era
A new paper from American University examines the economics of an aquaculture industry of the future that is simultaneously environmentally sustainable and nutritious for the nearly 1 billion people worldwide who depend on it.

Fathers are more likely to be referred for nutrition or exercise counseling
Fatherhood status has been linked to medical providers' weight-related practices or counseling referrals.

Refugee children get better health, nutrition via e-vouchers
Electronic food vouchers provided young Rohingya children in Bangladeshi refugee camps with better health and nutrition than direct food assistance, according to new research led by Cornell University, in conjunction with the International Food Policy Research Institute.

Leaders call for 'Moonshot' on nutrition research
Leading nutrition and food policy experts outline a bold case for strengthening federal nutrition research in a live interactive session as part of NUTRITION 2020 LIVE ONLINE, a virtual conference hosted by the American Society for Nutrition (ASN).

Featured research from NUTRITION 2020 LIVE ONLINE
Press materials are now available for NUTRITION 2020 LIVE ONLINE, a dynamic virtual event showcasing new research findings and timely discussions on food and nutrition.

Diet, nutrition have profound effects on gut microbiome
A new literature review from scientists at George Washington University and the National Institute of Standards and Technology suggests that nutrition and diet have a profound impact on the microbial composition of the gut.

Are women getting adequate nutrition during preconception and pregnancy?
In a Maternal & Child Nutrition analysis of published studies on the dietary habits of women who were trying to conceive or were pregnant, most studies indicated that women do not meet nutritional recommendations for vegetable, cereal grain, or folate intake.

Supermarkets and child nutrition in Africa
Hunger and undernutrition are widespread problems in Africa. At the same time, overweight, obesity, and related chronic diseases are also on the rise.

Read More: Nutrition News and Nutrition Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.