Journal issue honors 20th anniversary of Marshall University researcher's discovery

October 02, 2018

HUNTINGTON, W.Va. - Twenty years ago, Zijian Xie, Ph.D., director of the Marshall Institute for Interdisciplinary Research and professor in the department of biomedical sciences at the Marshall University Joan C. Edwards School of Medicine, discovered the scaffolding/signaling function of the Na/K-ATPase sodium pump, a significant research finding that has had tremendous applications in both biology and medicine.

In honor of this milestone and the impact of Xie's discovery on cell biology, the International Journal of Molecular Sciences has released a special issue featuring articles related to this scaffolding/signaling function. The special issue is co-edited by Joseph I. Shapiro, M.D., dean and professor of medicine at the Joan C. Edwards School of Medicine, and V. Gustavo Blanco, M.D., Ph.D., professor and chair of the department of Molecular and Integrative Physiology at University of Kansas Medical Center.

"This special issue is a marvelous tribute to a truly seminal discovery by my dear friend and colleague of more than 20 years," Shapiro said.

Xie's work during the last 35 years has been dedicated to understanding the behavior of cellular pathways and their relationship to cancer, renal disease and cardiac failure. Xie came to Marshall in 2013 from the University of Toledo, where his discovery of the scaffolding/signaling function was made. Xie holds international patents and patent applications on seven medical inventions resulting from his research. He has served as principal investigator, project leader and co-investigator on National Institutes of Health-funded projects and has established active international collaborations. He is the author or co-author of more than 100 articles published in scientific journals and has authored a number of book chapters.

"Dr. Xie's pioneering observations of the scaffolding and signaling function of Na,K-ATPase had a great impact on our understanding of cell biology and opened a new area of research," Blanco said. "The articles in this special issue are a testimony of the expansion of this novel and exciting field of study."
-end-
The International Journal of Molecular Sciences is an international peer-reviewed open access monthly journal published by MDPI. View the complete special issue at http://www.mdpi.com/journal/ijms/special_issues/sodium_pump.

Marshall University Joan C. Edwards School of Medicine

Related Biology Articles from Brightsurf:

Experimental Biology press materials available now
Though the Experimental Biology (EB) 2020 meeting was canceled in response to the COVID-19 outbreak, EB research abstracts are being published in the April 2020 issue of The FASEB Journal.

Structural biology: Special delivery
Bulky globular proteins require specialized transport systems for insertion into membranes.

Cell biology: All in a flash!
Scientists of Ludwig-Maximilians-Universitaet (LMU) in Munich have developed a tool to eliminate essential proteins from cells with a flash of light.

A biology boost
Assistance during the first years of a biology major leads to higher retention of first-generation students.

Cell biology: Compartments and complexity
Ludwig-Maximilians-Universitaet (LMU) in Munich biologists have taken a closer look at the subcellular distribution of proteins and metabolic intermediates in a model plant.

Cell biology: The complexity of division by two
Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have identified a novel protein that plays a crucial role in the formation of the mitotic spindle, which is essential for correct segregation of a full set of chromosomes to each daughter cell during cell division.

Cell biology: Dynamics of microtubules
Filamentous polymers called microtubules play vital roles in chromosome segregation and molecular transport.

The biology of color
Scientists are on a threshold of a new era of color science with regard to animals, according to a comprehensive review of the field by a multidisciplinary team of researchers led by professor Tim Caro at UC Davis.

Kinky biology
How and why proteins fold is a problem that has implications for protein design and therapeutics.

A new tool to decipher evolutionary biology
A new bioinformatics tool to compare genome data has been developed by teams from the Max F.

Read More: Biology News and Biology Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.